Results 131 to 140 of about 16,783,451 (339)

Functional Influence of the Pore Helix Glutamate in the KcsA K+ Channel [PDF]

, 2004
HoSook Choi, Lise Heginbotham
openalex   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Quantum Chemical Calculation of pK_as of Environmentally Relevant Functional Groups: Carboxylic Acids, Amines, and Thiols in Aqueous Solution

, 2018
Peng Lian, Ryne C. Johnston, Jerry M. Parks, Jeremy C. Smith   +3 more
openalex   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

On q-Szász-Durrmeyer operators

Open Mathematics, 2010
Mahmudov Nazim, Kaffaoğlu Havva
doaj   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Existence of isoperimetric regions in sub-Finsler nilpotent groups

Analysis and Geometry in Metric Spaces
We consider a nilpotent Lie group with a bracket-generating distribution ℋ{\mathcal{ {\mathcal H} }} and an asymmetric left-invariant norm ∣⋅∣K{| \cdot | }_{K} induced by a convex body K⊆RkK\subseteq {{\mathbb{R}}}^{k} containing 0 in its interior.
Pozuelo Julián
doaj   +1 more source

Functional k-Nearest Neighbors algorithm based on the Fisher-Rao metric [PDF]

Kyungmin Ahn
openalex   +1 more source

Convergence of functional k-nearest neighbor regression estimate with functional responses [PDF]

, 2011
Heng Lian
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source