Results 121 to 130 of about 1,981,824 (263)
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Jurnal RESTI (Rekayasa Sistem dan Teknologi Informasi)Indonesia’s frequent earthquakes, caused by its position at the convergence of multiple tectonic plates, Indonesia's frequent earthquakes, caused by its position at the convergence of multiple tectonic plates, necessitate precise seismic zone ...
Nurfidah Dwitiyanti +2 more
doaj +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
k-means- ja k-means++-algoritmien teoreettinen tarkastelu
, 2020 Tutkielmassa tarkastellaan teoreettisesta näkökulmasta katsottuna kahta koneoppimisialgoritmia; k-means- ja k-means++. Tarkasteltavat menetelmät ovat klusterointialgoritmejä. Aluksi k-means-algoritmia tarkastellaan esimerkin ja kuvien avulla sekä esitellään SSE-ongelma, jonka k-means-algoritmi ratkaisee minimoilla sen kustannusfunktion arvon.
openaire +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Semesta Teknika, 2016 The selection process among outstanding students in a department has a big problem. This process is not fair because only involve one criteria and ignore the other criteria.
Asroni Asroni, Ronald Adrian
doaj
A review of unsupervised k-value selection techniques in clustering algorithms
Journal of Industrial Engineering and ManagementPurpose: Automatic grouping of data according to certain characteristics is made possible by clustering algorithms, which makes them an essential tool when working with large datasets. However, although they are unsupervised tools, they generally require
Ana Pegado-Bardayo +3 more
doaj +1 more source