Results 1 to 10 of about 55,431 (122)

Kefir-derived probiotic mixture for children with autism spectrum disorder: a double-blind randomized clinical trial [PDF]

BMC Pediatrics
Purpose Emerging evidence suggests associations between gut microbiota patterns and autism-related behavioral and gastrointestinal features, increasing interest in probiotic interventions.
Sarha A. L. de Queiroz, Deivis O. Guimarães, Lara A. Ferreira, Larissa Martinelli, Rebeca M. M. Werly, Raphaela F. Amorim, Lívia B. S. S. Holzbach, Roberto Badaró, Alex A. B. Santos, Elisardo C. Vasquez, Racire S. Silva   +10 more
doaj   +2 more sources

Structural basis of K11/K48-branched ubiquitin chain recognition by the human 26S proteasome [PDF]

Nature Communications
Beyond the canonical K48-linked homotypic polyubiquitination for proteasome-targeted proteolysis, K11/K48-branched ubiquitin (Ub) chains are involved in fast-tracking protein turnover during cell cycle progression and proteotoxic stress.
Piotr Draczkowski, Szu-Ni Chen, Ting Chen, Yong-Sheng Wang, Hsin-An Shih, Jessica Y. C. Huang, Ming-Chieh Tsai, Shu-Yu Lin, Steven Lin, Rosa Viner, Yuan-Chih Chang, Kuen-Phon Wu, Shang-Te Danny Hsu   +12 more
doaj   +2 more sources

The deubiquitinating enzyme Cezanne stabilizes BRCA1 by counteracting APC/C and Ube2S-dependent Lys11-linked ubiquitination. [PDF]

PLoS Biology
The breast and ovarian tumor suppressor BRCA1 is a cell cycle-regulated protein and tumors with reduced BRCA1 protein level may share molecular features of BRCA1-mutant tumor and respond to PARPi therapy. Here, we identify that BRCA1 protein stability is
Longqiang Wang, Xiao Wu, Atanu Paul, Jun Yao, Bin Wang   +4 more
doaj   +2 more sources

RNF114 and RNF166 exemplify reader-writer E3 ligases that extend K11 polyubiquitin onto sites of MARUbylation [PDF]

The EMBO Journal
Ubiquitin (Ub) cooperates with other post-translational modifications to provide a tiered opportunity for protein regulation. Deltex E3 ligases were previously implicated in ubiquitylation of ADP-ribose (ADPr)-containing macromolecules in vitro ...
Rachel E Lacoursiere, Kapil Upadhyaya, Jasleen Kaur Sidhu, Ivan Rodriguez Siordia, Daniel S Bejan, Michael S Cohen, Jonathan N Pruneda   +6 more
doaj   +2 more sources

TRIM21‐Mediated K11‐Linked Ubiquitination of ID1 Suppresses Tumorigenesis and Promotes Cuproptosis in Esophageal Squamous Cell Carcinoma [PDF]

Advanced Science
Inhibitor of DNA binding 1 (ID1) is a key transcriptional regulator involved in the development of various cancers, including esophageal squamous cell carcinoma (ESCC). However, the mechanisms regulating ID1 ubiquitination in ESCC are not well understood.
Lei Li, Yuqing Wang, Ruoxi Tian, Tianshuo Yang, Yaxin Liu, Baoen Shan, Lianmei Zhao   +6 more
doaj   +2 more sources

Synergistic effect and antibiofilm activity of the antimicrobial peptide K11 with conventional antibiotics against multidrug-resistant and extensively drug-resistant Klebsiella pneumoniae

Frontiers in Cellular and Infection Microbiology, 2023
IntroductionInfections caused by drug-resistant Klebsiella pneumoniae are now a serious problem for public health, associated with high morbidity and mortality due to limited treatment options.
Chawalit Chatupheeraphat, Jiratchaya Peamchai, Sirirat Luk-in, Warawan Eiamphungporn   +3 more
doaj   +1 more source

Personalized radiomics signature to screen for KIT-11 mutation genotypes among patients with gastrointestinal stromal tumors: a retrospective multicenter study

Journal of Translational Medicine, 2023
Objectives Gastrointestinal stromal tumors (GISTs) carrying different KIT exon 11 (KIT-11) mutations exhibit varying prognoses and responses to Imatinib. Herein, we aimed to determine whether computed tomography (CT) radiomics can accurately stratify KIT-
Qing-Wei Zhang, Ran-Ying Zhang, Zhi-Bo Yan, Yu-Xuan Zhao, Xin-Yuan Wang, Jing-Zheng Jin, Qi-Xuan Qiu, Jie-Jun Chen, Zhen-Hui Xie, Jiang Lin, Hui Cao, Yan Zhou, Hui-Min Chen, Xiao-Bo Li   +13 more
doaj   +1 more source

Management of Facilities at Public Universities in Africa: Current Challenges and the Way Forward

Real Estate Management and Valuation, 2021
This paper provides an overview of the challenges of management of facilities at public universities in Africa. Results reveal that: poor condition and the overcrowding of facilities, limited skills and capabilities of facility management departments ...
Chikafalimani Samuel H.P., Kibwami Nathan, Moyo Sibusiso   +2 more
doaj   +1 more source

Assessing Renewable Energy Practice in Turaki Ali House Kaduna-Nigeria

Real Estate Management and Valuation, 2021
The research investigated tenant understanding and preparedness to embrace renewable energy practice as an alternative to public power supply during an outage from the national grid.
Sani Habibu, Aliyu Bilkisu Adamu, Nuhu Siddique R.   +2 more
doaj   +1 more source

An Investigation Into the Use of “Hybrid” Adjustment Techniques in the Application of the Sales Comparison Method in Residential Valuation

Real Estate Management and Valuation, 2021
The sales comparison is the most common and universally accepted method in valuation. Although the theoretical entry point of the method is the same across most continents, its application in practice is varied and often determined by local circumstances.
Munshifwa Ephraim K.
doaj   +1 more source