Structural basis of K11/K48-branched ubiquitin chain recognition by the human 26S proteasome [PDF]
Nature CommunicationsBeyond the canonical K48-linked homotypic polyubiquitination for proteasome-targeted proteolysis, K11/K48-branched ubiquitin (Ub) chains are involved in fast-tracking protein turnover during cell cycle progression and proteotoxic stress.
Piotr Draczkowski +12 more
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The deubiquitinating enzyme Cezanne stabilizes BRCA1 by counteracting APC/C and Ube2S-dependent Lys11-linked ubiquitination. [PDF]
PLoS BiologyThe breast and ovarian tumor suppressor BRCA1 is a cell cycle-regulated protein and tumors with reduced BRCA1 protein level may share molecular features of BRCA1-mutant tumor and respond to PARPi therapy. Here, we identify that BRCA1 protein stability is
Longqiang Wang +4 more
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RNF114 and RNF166 exemplify reader-writer E3 ligases that extend K11 polyubiquitin onto sites of MARUbylation [PDF]
The EMBO JournalUbiquitin (Ub) cooperates with other post-translational modifications to provide a tiered opportunity for protein regulation. Deltex E3 ligases were previously implicated in ubiquitylation of ADP-ribose (ADPr)-containing macromolecules in vitro ...
Rachel E Lacoursiere +6 more
doaj +2 more sources
The Design and Construction of K11: A Novel α-Helical Antimicrobial Peptide [PDF]
International Journal of Microbiology, 2012 Amphipathic α-helical antimicrobial peptides comprise a class of broad-spectrum agents that are used against pathogens. We designed a series of antimicrobial peptides, CP-P (KWKSFIKKLTSKFLHLAKKF) and its derivatives, and determined their minimum ...
Huang Jin-Jiang +4 more
doaj +3 more sources
RNF167 mediates atypical ubiquitylation and degradation of RLRs via two distinct proteolytic pathways [PDF]
Nature CommunicationsThe precise regulation of the RIG-I-like receptors (RLRs)-mediated type I interferon (IFN-I) activation is crucial in antiviral immunity and maintaining host immune homeostasis in the meantime.
Miao He +18 more
doaj +2 more sources
TRIM21‐Mediated K11‐Linked Ubiquitination of ID1 Suppresses Tumorigenesis and Promotes Cuproptosis in Esophageal Squamous Cell Carcinoma [PDF]
Advanced ScienceInhibitor of DNA binding 1 (ID1) is a key transcriptional regulator involved in the development of various cancers, including esophageal squamous cell carcinoma (ESCC). However, the mechanisms regulating ID1 ubiquitination in ESCC are not well understood.
Lei Li +6 more
doaj +2 more sources
Cloning and Purification of Bacteriophage K11 RNA Polymerase [PDF]
BioTechniques, 1999 Minqing Rong +2 more
doaj +3 more sources
Frontiers in Cellular and Infection Microbiology, 2023 IntroductionInfections caused by drug-resistant Klebsiella pneumoniae are now a serious problem for public health, associated with high morbidity and mortality due to limited treatment options.
Chawalit Chatupheeraphat +3 more
doaj +1 more source
Journal of Translational Medicine, 2023 Objectives Gastrointestinal stromal tumors (GISTs) carrying different KIT exon 11 (KIT-11) mutations exhibit varying prognoses and responses to Imatinib. Herein, we aimed to determine whether computed tomography (CT) radiomics can accurately stratify KIT-
Qing-Wei Zhang +13 more
doaj +1 more source
Identification of Bacteriophage K11 Genomic Promoters for K11 RNA Polymerase [PDF]
BMB Reports, 2002 Only one natural promoter that interacts with bacteriophage K11 RNA polymerase has so far been identified. To identify more, in the present study restriction fragments of the phage genome were individually assayed for transcription activity in vitro. The K11 genome was digested with two 4-bp-recognizing restriction enzymes, and the fragments cloned in ...
Kyung Goo, Han +4 more
openaire +2 more sources