Results 61 to 70 of about 55,507 (190)
Unique Structural, Dynamical, and Functional Properties of K11-Linked Polyubiquitin Chains [PDF]
Structure, 2013 K11-linked polyubiquitin chains play important signaling and regulatory roles in both degradative and nonproteolytic pathways in eukaryotes. To understand the structural basis of how these chains are recognized and distinguished from other polyubiquitins, we determined solution structures of K11-linked diubiquitin (K11-Ub2) in the absence and presence ...
Castañeda, Carlos A +4 more
openaire +3 more sources
, 2005 We consider a few topics in $E_{11}$ approach to superstring/M-theory: even subgroups ($Z_2$ orbifolds) of $E_{n}$, n=11,10,9 and their connection to Kac-Moody algebras; $EE_{11}$ subgroup of $E_{11}$ and coincidence of one of its weights with the $l_1 ...
Brown J. +9 more
core +3 more sources
Advanced Science, EarlyView.This study delineates a novel HSP90AB1‐ITGBL1 signaling axis governing osteosarcoma. HSP90AB1 promotes K63‐linked ubiquitination and proteasomal degradation of ITGBL1. Restoring ITGBL1 induces reactive oxygen species‐dependent endoplasmic reticulum stress and pro‐death autophagy, suppressing tumor growth and metastasis.
Zhen Wang +17 more
wiley +1 more source
Exocellular β-Lactamases of Streptomyces albus G and Strains R39 and K11 [PDF]
Antimicrobial Agents and Chemotherapy, 1973 The β-lactamases excreted by the highly benzylpenicillin-susceptible Streptomyces strain R39 and the highly benzylpenicillin-resistant Streptomyces albus G were isolated and purified. Neither β-lactamase exhibited dd -carboxypeptidase activity. Both were anionic at
Johnson, Kenneth +3 more
openaire +3 more sources
Сибирский онкологический журнал, 2022 The purpose of the study: to conduct a systematic literature review on the effectiveness and feasibility of using information on the presence of KRAS gene mutations (in different codons), TP 53 (KP), ST K11/LKB1 (KL), and KEAP mutations and the ...
K. K. Laktionov +4 more
doaj +1 more source
Advanced Science, EarlyView.We identify an antagonistic ubiquitin circuit that controls cellular permissiveness to multiple coronaviruses. The deubiquitinase USP7 stabilizes the epigenetic regulator KDM6A to upregulate viral receptors, while the E3 ligase RNF40 degrades KDM6A by catalyzing K6/K11‐ubiquitin chains of KDM6A for autophagic degradation.
Meng‐Zhuo Huang +9 more
wiley +1 more source
The four known biplanes with k=11
International Journal of Mathematics and Mathematical Sciences, 1979 The four known biplanes of order 9(k=11) are described in terms of their ovals, λ-chain structures, and automorphism groups. An exhaustive computer search for all biplanes of order 9 with certain chain structures has produced but two, one of which is new.
Chester J. Salwach, Joseph A. Mezzaroba
doaj +1 more source
Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis
Advanced Science, EarlyView.Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason +12 more
wiley +1 more source
Private Property in Communist Czechoslovakia
Review of Economic Perspectives, 2015 This article analyses the development of legislation regarding private property in Czechoslovakia between 1948 and 1989 and summarizes available empirical data relating to property rights protection in the given period.
Demela Jan, Mikula Štěpán
doaj +1 more source
Elasticity Theory of a Twisted Stack of Plates [PDF]
, 1997 We present an elastic model of B-form DNA as a stack of thin, rigid plates or base pairs that are not permitted to deform. The symmetry of DNA and the constraint of plate rigidity limit the number of bulk elastic constants contributing to a macroscopic ...
Kamien, Randall D. +3 more
core +3 more sources