Results 61 to 70 of about 55,514 (192)

Cleavage‐Resistant CYLD Protects Against Autoimmune Hepatitis

Advanced Science, EarlyView.
Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Han Liu, Chen Su, Jianling Liu, Mingyan Xing, Xiaoxia Wu, Lingxia Wang, Xiaoming Zhao, Hanwen Zhang, YangYang Xie, YangYang Wang, Hong Li, Yu Li, Ming Li, Haibing Zhang   +13 more
wiley   +1 more source

Mutation in the kras gene as a predictor of the effectiveness of immunotherapy for non-small cell lung cancer

Сибирский онкологический журнал, 2022
The purpose of the study: to conduct a systematic literature review on the effectiveness and feasibility of using information on the presence of KRAS gene mutations (in different codons), TP 53 (KP), ST K11/LKB1 (KL), and KEAP mutations and the ...
K. K. Laktionov, A. M. Kazakov, K. A. Sarantseva, D. S. Scherbo, A. P. Koval   +4 more
doaj   +1 more source

UKIDSS detections of cool brown dwarfs - proper motions of 14 known $>$T5 dwarfs and discovery of three new T5.5-T6 dwarfs

, 2012
AIMS: We contribute to improving the census of cool brown dwarfs (late-T and Y dwarfs) in the immediate solar neighbourhood. METHODS: By combining near-infrared (NIR) data of UKIDSS with mid-infrared WISE and other available NIR (2MASS) and red optical ...
Abazajian, Ageorges, Aihara, Albert, Burgasser, Burgasser, Burgasser, Burgasser, Burningham, Burrows, Casali, Chiu, Chiu, Cushing, Delorme, Dye, Faherty, G. Bihain, Geballe, Gudehus, Hambly, Hewett, J. Storm, Jameson, Kirkpatrick, Lawrence, Liu, Lodieu, Lodieu, Lodieu, Lucas, Mandel, Marocco, O. Schnurr, Pier, Pinfield, Pinfield, R.-D. Scholz, Scholz, Scholz, Seifert, Skrutskie, Tinney, Tokunaga, Tsvetanov, Warren, Wright   +46 more
core   +1 more source

Exocellular β-Lactamases of Streptomyces albus G and Strains R39 and K11 [PDF]

Antimicrobial Agents and Chemotherapy, 1973
The β-lactamases excreted by the highly benzylpenicillin-susceptible Streptomyces strain R39 and the highly benzylpenicillin-resistant Streptomyces albus G were isolated and purified. Neither β-lactamase exhibited dd -carboxypeptidase activity. Both were anionic at
Johnson, Kenneth, Dusart, Jean, Campbell, James N., Ghuysen, Jean-Marie   +3 more
openaire   +3 more sources

F‐Box and Leucine‐Rich Repeat Protein 4 (FBXL4) Maintains Sarcomere Integrity and Cardiac Function by Enhancing K48‐Linked Ubiquitinated Degradation of Profilin‐1 (PFN1)

Advanced Science, EarlyView.
Schematic diagram depicting the proposed signaling mechanisms underlying the effects of FBXL4 in the setting of cardiac hypertrophy. Under hypertrophic stimulation, cardiomyocytes‐specific overexpression FBXL4 maintains sarcomere integrity and cardiac function by enhancing K48‐linked ubiquitinated degradation of PFN1 at the K70 site.
Xingda Li, Xueqi He, Xinyuan Hao, Yu Zhang, Xin Zhao, Shuang Wang, Zhenru Wang, Haonan Du, Hongda Li, Lian Yi, Zhimin Du, Weijie Du   +11 more
wiley   +1 more source

Macrophage TRIM21 Inhibition Ameliorates Murine Acute Pancreatitis via PHB2‐Mediated Mitochondrial Stabilization

Advanced Science, EarlyView.
Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu, Yuansong Sun, Xin Zhou, Kai Song, Chunlin Yin, Zhaohua Wang, Fei Xie, He Li   +7 more
wiley   +1 more source

The four known biplanes with k=11

International Journal of Mathematics and Mathematical Sciences, 1979
The four known biplanes of order 9(k=11) are described in terms of their ovals, λ-chain structures, and automorphism groups. An exhaustive computer search for all biplanes of order 9 with certain chain structures has produced but two, one of which is new.
Chester J. Salwach, Joseph A. Mezzaroba
doaj   +1 more source

Multiple E3 ligases control tankyrase stability and function

Nature Communications, 2023
Tankyrase 1 and 2 are ADP-ribosyltransferases that catalyze formation of polyADP-Ribose (PAR) onto themselves and their binding partners. Tankyrase protein levels are regulated by the PAR-binding E3 ligase RNF146, which promotes K48-linked ...
Jerome Perrard, Susan Smith
doaj   +1 more source

$C_{n}^{(1)}$, $D_{n}^{(1)}$ and $A_{2n-1}^{(2)}$ reflection K-matrices

, 2003
We investigate the possible regular solutions of the boundary Yang-Baxter equation for the vertex models associated with the $C_{n}^{(1)}$, $D_{n}^{(1)}$ and $A_{2n-1}^{(2)}$ affine Lie algebras.
A. Lima-Santos, Abad, Abdalla, Ahn, Arnaudon, Baseilhac, Batchelor, Batchelor, Baxter, Bazhanov, Behrend, Bowcock, Cherednik, de Vega, de Vega, Delius, Fring, Gandenberger, Ghoshal, Inami, Jimbo, Kim, Korepin, Kulish, Kulish, Lima-Santos, Lima-Santos, Lima-Santos, Lima-Santos, Liu, Mackay, Martins, Mezincescu, Mezincescu, Mezincescu, Mezincescu, Moriconi, Nepomechie, R. Malara, Sklyanin   +39 more
core   +1 more source

Chaperone‐Mediated Autophagic Degradation of USP9X in Macrophages Exacerbates Postmyocardial Infarction Inflammation and Cardiac Dysfunction

Advanced Science, EarlyView.
This study demonstrates that inflammatory stimuli induce the acetylation‐triggered, chaperone‐mediated autophagic degradation of ubiquitin‐specific peptidase 9 X‐linked (USP9X) in macrophages. USP9X acts as a macrophage “inflammation switch” after myocardial infarction (MI). USP9X loss destabilizes tumor necrosis factor receptor‐associated factor (TRAF)
Biqing Wang, Xiangheng Cai, Mengqi Li, Xue Liu, Junhui Xue, Ye Liu, Ding Ai, Xinyang Hu   +7 more
wiley   +1 more source