Results 51 to 60 of about 8,978 (189)
Understanding K11‐ polyubiquitin recognition at the 26S Proteasome
The FASEB Journal, 2013 Ubiquitination, the covalent attachment of ubiquitin to target proteins, is a reversible post‐translational modification that regulates many important cellular processes. Ubiquitin chains linked at Lys48 (K48) serve as a signal for proteasomal degradation; whereas K63‐linked chains have non‐proteolytic function.
Joseph Chaney, Chittaranjan Das
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Exocellular β-Lactamases of Streptomyces albus G and Strains R39 and K11 [PDF]
Antimicrobial Agents and Chemotherapy, 1973 The β-lactamases excreted by the highly benzylpenicillin-susceptible Streptomyces strain R39 and the highly benzylpenicillin-resistant Streptomyces albus G were isolated and purified. Neither β-lactamase exhibited dd -carboxypeptidase activity. Both were anionic at
Johnson, Kenneth +3 more
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Getting Close: Insight into the Structure and Function of K11/K48-Branched Ubiquitin Chains [PDF]
Structure, 2020 K11/K48-branched ubiquitin chains are proteasomal priority signals that elicit the rapid elimination of mitotic regulators and aggregation-prone proteins. Indicative of an intriguing signaling mode, Boughton et al. (2019) unravel an interaction between distal subunits of K11/K48-branched ubiquitin trimers that could provide a combined surface for ...
Regina, Baur, Michael, Rape
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Advanced Science, EarlyView.This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu +6 more
wiley +1 more source
Ways of Acquiring Land Property for the Construction of Province Roads
Real Estate Management and Valuation, 2018 The topic of this article is related to issues connected with public roads. The thematic scope of the work includes the presentation and analysis of the legal regulations governing the acquisition of real estate under provincial public roads. The purpose
Noga Karol +2 more
doaj +1 more source
Advanced Science, EarlyView.Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou +11 more
wiley +1 more source
Advanced Science, EarlyView.Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng +10 more
wiley +1 more source
Advanced Science, EarlyView.This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li +15 more
wiley +1 more source
The four known biplanes with k=11
International Journal of Mathematics and Mathematical Sciences, 1979 The four known biplanes of order 9(k=11) are described in terms of their ovals, λ-chain structures, and automorphism groups. An exhaustive computer search for all biplanes of order 9 with certain chain structures has produced but two, one of which is new.
Chester J. Salwach, Joseph A. Mezzaroba
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OTUD6A promotes prostate tumorigenesis via deubiquitinating Brg1 and AR
Communications Biology, 2022 OTUD6A, a deubiquitinase, is amplified in prostate cancer and correlates with poor survivability, increasing the growth of prostate cancer cell lines and PDX models.
Xuhong Fu +11 more
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