Results 61 to 70 of about 11,042 (207)

Mutation in the kras gene as a predictor of the effectiveness of immunotherapy for non-small cell lung cancer

Сибирский онкологический журнал, 2022
The purpose of the study: to conduct a systematic literature review on the effectiveness and feasibility of using information on the presence of KRAS gene mutations (in different codons), TP 53 (KP), ST K11/LKB1 (KL), and KEAP mutations and the ...
K. K. Laktionov, A. M. Kazakov, K. A. Sarantseva, D. S. Scherbo, A. P. Koval   +4 more
doaj   +1 more source

Chilean science teachers' conceptualisations of disability when teaching students with autism

British Educational Research Journal, EarlyView.
Abstract This study examines how Chilean secondary science teachers conceptualise disability when teaching students with autism in integrated classroom settings. Grounded in critical disability studies, the research employs a qualitative story‐completion method, using a fictional classroom scenario to prompt teachers to construct narratives that reveal
Alexis Gonzalez‐Donoso, Fabian Arroyo‐Rojas   +1 more
wiley   +1 more source

Soluble expression of cloned phage K11 RNA polymerase gene in Escherichia coli at a low temperature

, 1999
The gene 1 of the Klebsiella phage K11 encoding the phage RNA polymerase was amplified using the polymerase chain reaction of the Pfu DNA polymerase, cloned and expressed under the control of toe promoter in Escherichia coil.
KANG, Changwon, Lee, SS, Han, KG
core   +1 more source

Private Property in Communist Czechoslovakia

Review of Economic Perspectives, 2015
This article analyses the development of legislation regarding private property in Czechoslovakia between 1948 and 1989 and summarizes available empirical data relating to property rights protection in the given period.
Demela Jan, Mikula Štěpán
doaj   +1 more source

UBE2S drives elongation of K11-linked ubiquitin chains by the Anaphase-Promoting Complex [PDF]

Proceedings of the National Academy of Sciences, 2010
The Anaphase-Promoting Complex (APC) is an E3 ubiquitin ligase that regulates mitosis and G1 by sequentially targeting cell-cycle regulators for ubiquitination and proteasomal degradation. The mechanism of ubiquitin chain formation by APC and the resultant chain topology remains controversial.
Tao, Wu, Yifat, Merbl, Ying, Huo, Jennifer L, Gallop, Amit, Tzur, Marc W, Kirschner   +5 more
openaire   +2 more sources

A Naphthalenediimide–Imidazolium Macrocycle for Orthogonal Molecular Recognition

Chemistry – A European Journal, EarlyView.
One host, two recognition modes: a naphthalenediimide–imidazolium macrocycle switches between π‐driven encapsulation and hydrogen‐bonding to bind structurally diverse molecular and metal‐complex guests. ABSTRACT A naphthalenediimide‐imidazolium macrocycle is shown to function as a dual‐site supramolecular host for orthogonal molecular recognition.
Joel Martínez‐Visiedo, Susana Ibáñez, Eduardo Peris   +2 more
wiley   +1 more source

Multiple E3 ligases control tankyrase stability and function

Nature Communications, 2023
Tankyrase 1 and 2 are ADP-ribosyltransferases that catalyze formation of polyADP-Ribose (PAR) onto themselves and their binding partners. Tankyrase protein levels are regulated by the PAR-binding E3 ligase RNF146, which promotes K48-linked ...
Jerome Perrard, Susan Smith
doaj   +1 more source

Infection mechanisms of Rhizoctonia cerealis in wheat

iMeta, EarlyView.
We discover that R. cerealis (Rc) is a primary pathogen causing sharp eyespot of wheat after 335 distinct isolates were isolated from 1683 SE‐diseased wheat plants across China over 7 years using a single hyphal tip isolation method. We then generated high‐quality reference genomes via de novo sequencing of five representative Rc isolates and ...
Yan Ren, Ti Liu, Heying Zhao, Qirun Qian, Lufei Cui, Zhipeng Sun, Wenkai Yang, Peng Guo, Sisheng Wang, Lingran Zhang, Congwei Sun, Aolin Jia, Ning Zhang, Feng Chen   +13 more
wiley   +1 more source

Ter94 ATPase Complex Targets K11-Linked Ubiquitinated Ci to Proteasomes for Partial Degradation [PDF]

, 2013
SummaryThe Cubitus interruptus (Ci)/Gli family of transcription factors can be degraded either completely or partially from a full-length form (Ci155/GliFL) to a truncated repressor (Ci75/GliR) by proteasomes to mediate Hedgehog (Hh) signaling.
Wu, Wenqing, Yin, Wen-chi, Feng, Jing, Zhao, Yun, Zhang, Xiaoyun, Zhang, Zhao, Hui, Chi-chung, Lv, Xiangdong, Zhang, Lei   +8 more
core   +1 more source

Genetic analysis reveals functions of atypical polyubiquitin chains

eLife, 2018
Although polyubiquitin chains linked through all lysines of ubiquitin exist, specific functions are well-established only for lysine-48 and lysine-63 linkages in Saccharomyces cerevisiae.
Fernando Meza Gutierrez, Deniz Simsek, Arda Mizrak, Adam Deutschbauer, Hannes Braberg, Jeffrey Johnson, Jiewei Xu, Michael Shales, Michelle Nguyen, Raquel Tamse-Kuehn, Curt Palm, Lars M Steinmetz, Nevan J Krogan, David P Toczyski   +13 more
doaj   +1 more source