Results 61 to 70 of about 10,104 (229)

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

“Membrane‐Guided” Repair Strategy: Precision Delivery of GGT1 Degrader for Targeted Repair and Regeneration of Spinal Cord Neurons

Advanced Science, EarlyView.
This study confirms that GGT1 is a key driver of neuronal ferroptosis following spinal cord injury. We developed NSCm@EA, a biomimetic delivery system coated with neural stem cell membranes, for precise delivery of enocyanin to injured neurons. By combining targeted delivery with ubiquitination degradation mechanisms, this system promotes MGRN1 ...
Tao Yang, Lei Ye, Peigen Xie, Tao Song, Jian Chen, Heng Zhao, Zhengshan Liu, Xi Chen, Jianing Ding, Xintian Ding, Ao Shao, Miaomiao Wu, Fengdong Zhao, Siyue Tao, Tao You   +14 more
wiley   +1 more source

Einfluss des antierythrozytären Alloantikörpers K11 auf die Erythropoese [PDF]

, 2009
Die Arbeit befasst sich mit der Fragestellung, ob der Antierythrozytäre Alloantikörper K11 die Erythropoese beeinflussen kann. Zunächst musste ein reproduzierbares Zellkulturmodell für hämatopoetische Stammzellen erstellt werden, welches zudem möglichst ...
Yasin, Yousef
core  

ZDHHC18‐Mediated Palmitoylation of ORF3a Promotes SARS‐CoV‐2 Pathogenesis by Antagonizing TRIM16‐Mediated Ubiquitination and Proteasomal Degradation

Advanced Science, EarlyView.
Palmitoylation by ZDHHC18 blocks ORF3a K27‐linked ubiquitination mediated by TRIM16, thereby preventing its proteasomal degradation and strengthening viral pathogenesis. Targeting palmitoylation through a pharmacological inhibitor (2‐BP), a competitive inhibitory peptide (OPIP), or adenovirus‐mediated knockdown of ZDHHC18 expression presents a ...
Sidi Yang, Kun Li, Lihong Liu, Linsen Zeng, Qifeng Deng, Jiacheng Huang, Xiaoran Dong, Xin Wang, Jianwei Liang, Hongchao Liu, Hong Peng, Yuxin Lin, Xiaolu Xie, Yuzhen Ye, Tiefeng Xu, Zhaohuan Wang, Chun‐Mei Li, Deyin Guo   +17 more
wiley   +1 more source

Original movie used for reconstruction of 3D model of completed mystery circle K11

, 2022
Original movie used for reconstruction of 3D model of completed mystery circle K11 on the sandy seabed off Amami-Oshima Island, Japan, on June 15 ...
Yuki Kitajima (11921516), Daisuke Iwai (9999170), Hiroshi Kawase (2358493)   +2 more
core   +1 more source

OTUD6A promotes prostate tumorigenesis via deubiquitinating Brg1 and AR

Communications Biology, 2022
OTUD6A, a deubiquitinase, is amplified in prostate cancer and correlates with poor survivability, increasing the growth of prostate cancer cell lines and PDX models.
Xuhong Fu, Junjie Zhao, Guopeng Yu, Xiaomin Zhang, Jie Sun, Lingmeng Li, Jingyi Yin, Yinan Niu, Shancheng Ren, Yasheng Zhu, Bin Xu, Liyu Huang   +11 more
doaj   +1 more source

Mutation in the kras gene as a predictor of the effectiveness of immunotherapy for non-small cell lung cancer

Сибирский онкологический журнал, 2022
The purpose of the study: to conduct a systematic literature review on the effectiveness and feasibility of using information on the presence of KRAS gene mutations (in different codons), TP 53 (KP), ST K11/LKB1 (KL), and KEAP mutations and the ...
K. K. Laktionov, A. M. Kazakov, K. A. Sarantseva, D. S. Scherbo, A. P. Koval   +4 more
doaj   +1 more source

ZDHHC17‐Mediated CDK4 Palmitoylation Drives Cell Cycle Progression and Orchestrates Cancer Immune Surveillance

Advanced Science, EarlyView.
ZDHHC17 palmitoylates CDK4, which together with TRAF6‐mediated ubiquitination, drives cell cycle progression and immune surveillance, revealing a rational combination of CDK4 inhibitors with immune checkpoint blockers for ZDHHC17‐driven cancers. ABSTRACT Uncontrolled cell cycle progression is a hallmark of cancer, tightly regulated by both intrinsic ...
Zekang Wang, Peipei Song, Xueji Wu, Lei Wang, Wei Xie, Pinning Feng, Chao Cheng, Jianping Guo   +7 more
wiley   +1 more source

Efficient APC/C substrate degradation in cells undergoing mitotic exit depends on K11 ubiquitin linkages.

, 2015
The ubiquitin proteasome system (UPS) directs programmed destruction of key cellular regulators via posttranslational modification of its targets with polyubiquitin chains.

core   +1 more source

The four known biplanes with k=11

International Journal of Mathematics and Mathematical Sciences, 1979
The four known biplanes of order 9(k=11) are described in terms of their ovals, λ-chain structures, and automorphism groups. An exhaustive computer search for all biplanes of order 9 with certain chain structures has produced but two, one of which is new.
Chester J. Salwach, Joseph A. Mezzaroba
doaj   +1 more source