Results 71 to 80 of about 55,743 (197)

Genetic analysis reveals functions of atypical polyubiquitin chains

eLife, 2018
Although polyubiquitin chains linked through all lysines of ubiquitin exist, specific functions are well-established only for lysine-48 and lysine-63 linkages in Saccharomyces cerevisiae.
Fernando Meza Gutierrez, Deniz Simsek, Arda Mizrak, Adam Deutschbauer, Hannes Braberg, Jeffrey Johnson, Jiewei Xu, Michael Shales, Michelle Nguyen, Raquel Tamse-Kuehn, Curt Palm, Lars M Steinmetz, Nevan J Krogan, David P Toczyski   +13 more
doaj   +1 more source

Synthetic Strategies for Activity‐Based Probes to Decode Ubiquitin‐Like Modifiers

Chemistry – A European Journal, EarlyView.
ABSTRACT Ubiquitin‐like proteins (Ubls) such as SUMO, NEDD8, ISG15, URM1, UFM1, FAT10, ATG8/ATG12, and FUBI are essential regulators of cellular homeostasis, controlling processes from protein stability and trafficking to immune signaling and autophagy.
Saibal Chanda, Alan Pham, SreeNidhi Karnati, Natalia Soto Rodriguez, Alyssa Toner, Wenshe Ray Liu   +5 more
wiley   +1 more source

Surface hydration‐induced damage in tight oil‐bearing sandy conglomerate reservoirs

Deep Underground Science and Engineering, EarlyView.
A series of techniques such as X‐ray diffraction, scanning electron microscopy, energy‐dispersive spectroscopy, conductivity tests, and infrared thermal imaging were used. The key findings are the identification of a two‐stage surface hydration process and the elucidation of the effects of various minerals and elements on the hydration process ...
Anbang Zhao, Shuheng Du, Yuan Zhang, Jinghong Hu, Bo Zhou, Yun Wei   +5 more
wiley   +1 more source

Atmospheric Chemistry of CFH2CH2CH2CFH2: Kinetics and Mechanism of Reactions With Cl Atoms and OH Radicals

International Journal of Chemical Kinetics, EarlyView.
ABSTRACT The atmospheric chemistry of 1,4‐difluorobutane (CFH2CH2CH2CFH2) was investigated through a kinetic and mechanistic study of the reaction with chlorine (Cl) atoms and hydroxyl (OH) radicals. Using Fourier transform infrared (FTIR) spectroscopy and relative rate methods, the rate constants (k) for the reactions were determined at 298 ± 2 K as k(
Ellen R. Kjaergaard, Elena Jiménez, Connor Blair, Ole J. Nielsen, Mads P. Sulbaek Andersen   +4 more
wiley   +1 more source

Does Palsa Thaw in Northern Finland Contribute to Remobilisation of Metals Accumulated in Peat Into Surface Waters?

Land Degradation &Development, EarlyView.
ABSTRACT Permafrost is rapidly degrading in the sporadic zone, including palsa mires in Scandinavia. Peatlands in the area have likely accumulated heavy metals from atmospheric deposition of industrial contaminants in the wider region. As the palsa mire chemical composition is not well known, and in other permafrost regions the permafrost thaw may ...
Joanna Katarzyna Jóźwik, Krystyna Kozioł, Marcin Frankowski, Marta Jakubiak, Kamil Nowiński, Mariusz Jędrysek, Danuta Szumińska, Żaneta Polkowska   +7 more
wiley   +1 more source

Examining Heuristics for Building - Work-in-Progress Valuations in Niger State Nigeria

Real Estate Management and Valuation, 2018
Where an investment decision on building work-in-progress (BWIP) is premised on the judgment of value, the technique of assessment must be accurate. The heuristic technique has not been able to achieve this goal.
Babatunde Isaiah Olajide
doaj   +1 more source

Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12

Nature Communications, 2021
The tumor suppressor FBW7 is a substrate adaptor for the E3 ubiquitin ligase complex SKP1-CUL1-F-box (SCF) and itself a target for ubiquitylation. Here, the authors show that TRIP12 mediates branched K11-linked ubiquitylation of FBW7, to regulate its ...
Omar M. Khan, Jorge Almagro, Jessica K. Nelson, Stuart Horswell, Vesela Encheva, Kripa S. Keyan, Bruce E. Clurman, Ambrosius P. Snijders, Axel Behrens   +8 more
doaj   +1 more source

Numerical modelling of rubber vibration isolators [PDF]

, 2003
An important cause for interior noise in vehicles is structure-borne sound from the engine. The vibrations of the source (engine) are transmitted to the receiver structure (the vehicle) causing interior noise in the vehicle. For this reason the engine is
Beijers, Clemens A.J., Boer, André de
core   +1 more source

Noisy weak-lensing convergence peak statistics near clusters of galaxies and beyond

, 2010
Taking into account noise from intrinsic ellipticities of source galaxies, in this paper, we study the peak statistics in weak-lensing convergence maps around clusters of galaxies and beyond.
Albrecht, Bond, Bridle, Clowe, Erben, Fan, Hennawi, Huanyuan Shan, Jiayi Liu, Ma, Mandelbaum, Marian, Marian, Maturi, Mo, Schneider, Sun, Tang, Umetsu, Wang, White, Zhang, Zuhui Fan   +22 more
core   +1 more source

Cross‐Linking Mass Spectrometry of the Antimicrobial Peptides Magainin 2 and PGLa Reveals Heterodimerization in Micellar Medium

Rapid Communications in Mass Spectrometry, EarlyView.
ABSTRACT Rationale In this study, we applied cross‐linking mass spectrometry (XL‐MS) to characterize the oligomeric states of a PGLa/magainin 2 mixture and gain insight into the heterodimerization previously suggested in the literature. Both peptides have shown a synergistic enhancement of activity when tested in antimicrobial assays; however, the ...
Emilie Hirschler, Elise Glattard, Nicolas Arnaud, Johana Chicher, Philippe Hammann, Emmanuelle Leize‐Wagner, Burkhard Bechinger, Noelle Potier   +7 more
wiley   +1 more source