Results 71 to 80 of about 10,104 (229)
Advanced Science, EarlyView.The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao +8 more
wiley +1 more source
Private Property in Communist Czechoslovakia
Review of Economic Perspectives, 2015 This article analyses the development of legislation regarding private property in Czechoslovakia between 1948 and 1989 and summarizes available empirical data relating to property rights protection in the given period.
Demela Jan, Mikula Štěpán
doaj +1 more source
Advanced Science, EarlyView.This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu +6 more
wiley +1 more source
Multiple E3 ligases control tankyrase stability and function
Nature Communications, 2023 Tankyrase 1 and 2 are ADP-ribosyltransferases that catalyze formation of polyADP-Ribose (PAR) onto themselves and their binding partners. Tankyrase protein levels are regulated by the PAR-binding E3 ligase RNF146, which promotes K48-linked ...
Jerome Perrard, Susan Smith
doaj +1 more source
Ein chirales, sattelförmiges Nanographen mit zwei Heptagon‐integrierten [4]Helicenen
Angewandte Chemie, EarlyView.Wir präsentieren eine neuartige Synthesestrategie für ein chirales, sattelförmiges Nanographen (cSNG) über eine zweistufige Oxidation eines prochiralen Anthracen‐Vorläufers. Die Scholl‐Oxidation liefert zunächst ein Schlüsselzwischenprodukt mit sp3‐defekten Heptagonen, die anschließende oxidative Dehydrierung ergibt das vollständig konjugierte cSNG ...
Felix Trautner +11 more
wiley +1 more source
A Chiral Saddle‐Shaped Nanographene With Two Heptagon‐Embedded [4]Helicenes
Angewandte Chemie International Edition, EarlyView.We present a novel synthetic strategy toward a chiral saddle‐shaped nanographene (cSNG) via a two‐step oxidation of a prochiral anthracene precursor. The Scholl‐type oxidation first yields a key intermediate with sp3‐defect heptagons, and subsequent oxidative dehydrogenation affords fully conjugated cSNG.
Felix Trautner +11 more
wiley +1 more source
Examining Heuristics for Building - Work-in-Progress Valuations in Niger State Nigeria
Real Estate Management and Valuation, 2018 Where an investment decision on building work-in-progress (BWIP) is premised on the judgment of value, the technique of assessment must be accurate. The heuristic technique has not been able to achieve this goal.
Babatunde Isaiah Olajide
doaj +1 more source
Synthetic Strategies for Activity‐Based Probes to Decode Ubiquitin‐Like Modifiers
Chemistry – A European Journal, EarlyView.ABSTRACT Ubiquitin‐like proteins (Ubls) such as SUMO, NEDD8, ISG15, URM1, UFM1, FAT10, ATG8/ATG12, and FUBI are essential regulators of cellular homeostasis, controlling processes from protein stability and trafficking to immune signaling and autophagy.
Saibal Chanda +5 more
wiley +1 more source
The CCL-K11 on-going key comparison. Final report for the year 2017
, 2018 A laser from one national metrological institute (NMI) was compared in 2017 as part of the CCL-K11 on-going key comparison, initiated by the 13th meeting of the Comité Consultative des Longueurs (CCL) in 2007.
E Şahin, L Robertsson, S Acak, M Matus
core +1 more source
Cezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner [PDF]
, 2014 The transcription factor HIF-1α is essential for cells to rapidly adapt to low oxygen levels (hypoxia). HIF-1α is frequently deregulated in cancer and correlates with poor patient prognosis.
Anja Bremm +9 more
core +1 more source