Results 91 to 100 of about 8,978 (189)

RNF167 mediates atypical ubiquitylation and degradation of RLRs via two distinct proteolytic pathways

Nature Communications
The precise regulation of the RIG-I-like receptors (RLRs)-mediated type I interferon (IFN-I) activation is crucial in antiviral immunity and maintaining host immune homeostasis in the meantime.
Miao He, Zixiao Yang, Luyang Xie, Junhai Chen, Shurui Liu, Liaoxun Lu, Zibo Li, Birong Zheng, Yu Ye, Yuxin Lin, Lang Bu, Jingshu Xiao, Yongheng Zhong, Penghui Jia, Qiang Li, Yinming Liang, Deyin Guo, Chun-Mei Li, Panpan Hou   +18 more
doaj   +1 more source

ZDHHC17‐Mediated CDK4 Palmitoylation Drives Cell Cycle Progression and Orchestrates Cancer Immune Surveillance

Advanced Science, Volume 13, Issue 44, 7 August 2026.
ZDHHC17 palmitoylates CDK4, which together with TRAF6‐mediated ubiquitination, drives cell cycle progression and immune surveillance, revealing a rational combination of CDK4 inhibitors with immune checkpoint blockers for ZDHHC17‐driven cancers. ABSTRACT Uncontrolled cell cycle progression is a hallmark of cancer, tightly regulated by both intrinsic ...
Zekang Wang, Peipei Song, Xueji Wu, Lei Wang, Wei Xie, Pinning Feng, Chao Cheng, Jianping Guo   +7 more
wiley   +1 more source

A family of E3 ligases extend K11 polyubiquitin on sites of MARUbylation

Abstract Ubiquitin (Ub) cooperation with other post-translational modifications provides a tiered opportunity for protein regulation. Small modifications to Ub such as phosphorylation, acetylation, or ADP-ribosylation have varying impacts on signaling.
Rachel E Lacoursiere, Kapil Upadhyaya, Jasleen Kaur Sidhu, Daniel S Bejan, Ivan Rodriguez Siordia, Michael S Cohen, Jonathan N Pruneda   +6 more
openaire   +2 more sources

ROS‐ATM‐CBP axis‐mediated PARP1 lactylation aggravates doxorubicin‐induced cardiotoxicity

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
ROS function as signalling molecules to promote CBP‐mediated PARP1 lactylation in an ATM dependent manner, which induces PARP1 PARylation and ultimate cell apoptosis. CBP and SIRT1 as specific lactyltransferase and delactylase of PARP1. Lactylation of PARP1 depends on the LDHA activity and lactate production.
Wenbin Wang, Yingxian Sun
wiley   +1 more source

Exploring Knowledge, Attitudes, Practices, Environmental Concerns, and Barriers to Biodegradable Packaging Among University Students at Two Public Universities in Bangladesh: A Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aims Biodegradable packaging has gained increasing attention globally as an eco‐friendly alternative to conventional plastics with the aim of reducing environmental pollution and promoting sustainability. This study aimed to examine university students' knowledge, attitudes, and practices (KAP) along with the barriers and ...
Razia Sultana, Jannatun Naeem, Nadi Rani Dey, Maliha Tayaba, Sultan Mahmud Imran, Nitai Roy   +5 more
wiley   +1 more source

Ammonia Metabolism in the Aging Liver: Emerging Mechanistic Insights

Aging Cell, Volume 25, Issue 8, August 2026.
Liver aging may weaken ammonia‐detoxification reserve by disrupting mitochondrial ureagenesis, GS‐mediated scavenging, glutamine metabolism, and metabolic zonation. This emerging framework links impaired nitrogen handling to potential hepatic stress amplification and systemic crosstalk, while highlighting the need for direct validation in physiological
Heng Zhang, Guangyu Liang, Anding Liu
wiley   +1 more source

Repeated Use of Emergency Departments for Nontraumatic Dental Conditions: Factors Associated With Being a Superutilizer

Community Dentistry and Oral Epidemiology, Volume 54, Issue 4, Page 436-446, August 2026.
ABSTRACT Background Due to inadequate access to regular, affordable dental care, many patients turn to emergency departments (EDs) for the treatment of nontraumatic dental conditions (NTDCs). NTDC ED visits are a large burden on the U.S. healthcare system, with over 1.3 million visits each year and over $1 billion in associated charges.
Morgan Santoro, Lisa J. Heaton, Adrianna C. Sonnek, Rebecca A. Preston, John J. O'Malley, Eric P. Tranby   +5 more
wiley   +1 more source

Multifactorial nature of anabolic resistance in ageing skeletal muscle: A systems modelling study

The Journal of Physiology, Volume 604, Issue 15, Page 6405-6439, 1 August 2026.
Abstract figure legend We leveraged a kinetic model of muscle protein metabolism to investigate the multifactorial drivers of age‐related anabolic resistance. Literature‐derived putative mechanisms of anabolic resistance were integrated into the modelling framework to identify the primary determinants of the blunted postprandial muscle protein ...
Taylor J. McColl, Daniel R. Moore, Eldon Emberly, David D. Church, David C. Clarke   +4 more
wiley   +1 more source

Ein chirales, sattelförmiges Nanographen mit zwei Heptagon‐integrierten [4]Helicenen

Angewandte Chemie, Volume 138, Issue 31, 27 July 2026.
Wir präsentieren eine neuartige Synthesestrategie für ein chirales, sattelförmiges Nanographen (cSNG) über eine zweistufige Oxidation eines prochiralen Anthracen‐Vorläufers. Die Scholl‐Oxidation liefert zunächst ein Schlüsselzwischenprodukt mit sp3‐defekten Heptagonen, die anschließende oxidative Dehydrierung ergibt das vollständig konjugierte cSNG ...
Felix Trautner, Boris Borrisov, Philipp Royla, Hongqing Zhao, Hartmut Komber, Li Wan, Evgenia Dmitrieva, Ji Ma, Jan J. Weigand, Qun Yang, Xinliang Feng, Wenhui Niu   +11 more
wiley   +1 more source

A Chiral Saddle‐Shaped Nanographene With Two Heptagon‐Embedded [4]Helicenes

Angewandte Chemie International Edition, Volume 65, Issue 31, 27 July 2026.
We present a novel synthetic strategy toward a chiral saddle‐shaped nanographene (cSNG) via a two‐step oxidation of a prochiral anthracene precursor. The Scholl‐type oxidation first yields a key intermediate with sp3‐defect heptagons, and subsequent oxidative dehydrogenation affords fully conjugated cSNG.
Felix Trautner, Boris Borrisov, Philipp Royla, Hongqing Zhao, Hartmut Komber, Li Wan, Evgenia Dmitrieva, Ji Ma, Jan J. Weigand, Qun Yang, Xinliang Feng, Wenhui Niu   +11 more
wiley   +1 more source