Results 101 to 110 of about 10,104 (229)

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Structural characterization of interaction of K11 and K63 mixed-linkage polyubiquitin chains with the tUIMs of epsin1 [PDF]

, 2016
Ubiquitylation or covalent attachment of ubiquitin (Ub) to a variety of substrate proteins in cells is a versatile post-translational modification involved in the regulation of numerous cellular processes.
Kashyap, Tanuja
core   +1 more source

Atmospheric Chemistry of CFH2CH2CH2CFH2: Kinetics and Mechanism of Reactions With Cl Atoms and OH Radicals

International Journal of Chemical Kinetics, Volume 58, Issue 7, Page 396-406, July 2026.
ABSTRACT The atmospheric chemistry of 1,4‐difluorobutane (CFH2CH2CH2CFH2) was investigated through a kinetic and mechanistic study of the reaction with chlorine (Cl) atoms and hydroxyl (OH) radicals. Using Fourier transform infrared (FTIR) spectroscopy and relative rate methods, the rate constants (k) for the reactions were determined at 298 ± 2 K as k(
Ellen R. Kjaergaard, Elena Jiménez, Connor Blair, Ole J. Nielsen, Mads P. Sulbaek Andersen   +4 more
wiley   +1 more source

Optimizing Wind Power Plant Locations: A GIS‐Based Approach With Interval Type‐2 Fuzzy Risk Deviation Performance Index

Wind Energy, Volume 29, Issue 7, July 2026.
ABSTRACT This study develops an integrated GIS and multicriteria decision making (MCDM) approach supported by the Interval Type‐2 Fuzzy Risk Deviation Performance Index (IT2F‐RDPI) method to assess the wind energy potential in Diyarbakır Province. Fifteen criteria, including wind speed, slope, land use, elevation, soil structure, and proximity to ...
Ahmet Koç, Gökhan Şahin
wiley   +1 more source

O‐Terphenyl‐basierte Familie konjugierter Makrozyklen: Selektive Erkennung von Phenylalanin im Wasser und Interaktion mit Insulin

Angewandte Chemie, Volume 138, Issue 24, 8 June 2026.
Diese Studie beschreibt die Herstellung und Eigenschaften einer neuen Familie von o‐Terphenyl‐basierten Makrozyklen, TP[n] (n = 2‐8). Der Trimer bindet Phenylalanin in Wasser sehr effizient und ist dabei zehnmal selektiver als bei anderen Aminosäuren und aromatischen Neurotransmittern.
Swapnil Ghule, Sayan Sarkar, Maria Eugenia Pérez‐Ojeda Rodriguez, Mark Spector, Frank Hampel, Evgeny A. Kataev   +5 more
wiley   +1 more source

o‐Terphenyl‐Based Family of Conjugated Macrocycles: Selective Recognition of Phenylalanine in Water and Interaction With Insulin

Angewandte Chemie International Edition, Volume 65, Issue 24, 8 June 2026.
This study presents the synthesis and binding properties of a new family of o‐terphenyl‐based macrocycles, TP[n] (n = 2‐8). The trimer variant efficiently binds phenylalanine in water with a 10‐fold selectivity compared to other amino acids and aromatic neurotransmitters.
Swapnil Ghule, Sayan Sarkar, Maria Eugenia Pérez‐Ojeda Rodriguez, Mark Spector, Frank Hampel, Evgeny A. Kataev   +5 more
wiley   +1 more source

OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis

, 2013
Sixteen ovarian tumor (OTU) family deubiquitinases (DUBs) exist in humans, and most members regulate cell-signaling cascades. Several OTU DUBs were reported to be ubiquitin (Ub) chain linkage specific, but comprehensive analyses are missing, and the ...
Arnaudo, Nadia, Ekkebus, Reggy, El Oualid, Farid, Geurink, Paul P., Komander, David, Mevissen, Tycho E. T., Akutsu, Masato, Wauer, Tobias, Freund, Stefan M.V., Elliott, Paul R., Hospenthal, Manuela; id_orcid, Freund, Stefan M. V., Mevissen, Tycho E.T., Hospenthal, Manuela K., Kulathu, Yogesh, Ovaa, Huib   +15 more
core   +1 more source

RNF167 mediates atypical ubiquitylation and degradation of RLRs via two distinct proteolytic pathways

Nature Communications
The precise regulation of the RIG-I-like receptors (RLRs)-mediated type I interferon (IFN-I) activation is crucial in antiviral immunity and maintaining host immune homeostasis in the meantime.
Miao He, Zixiao Yang, Luyang Xie, Junhai Chen, Shurui Liu, Liaoxun Lu, Zibo Li, Birong Zheng, Yu Ye, Yuxin Lin, Lang Bu, Jingshu Xiao, Yongheng Zhong, Penghui Jia, Qiang Li, Yinming Liang, Deyin Guo, Chun-Mei Li, Panpan Hou   +18 more
doaj   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, Volume 600, Issue 12, Page 1729-1743, June 2026.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

KAJIAN KONSEP ARSITEKTUR SURYA PASIF PADA BANGUNAN MALL K11 ART MALL SHANGHAI / KOKAISTUDIOS

, 2021
Arsitektur surya pasif adalah suatu konsep yang mengedepankan pemanfaatan energi matahari dan udara yang bisa diterapkan pada bangunan dengan cara memberikan bukaan yang tepat dan material yang dapat menyimpan dan menyebarkan panas pada ruang dalam ...
Bumi, Barrery Reza, Satwikasari, Anggana Fitri   +1 more
core