Results 101 to 110 of about 11,042 (207)

Microprotein MP104 Promotes Malignant Progression of Colorectal Cancer Through Regulating Protein Translation

Advanced Science, Volume 13, Issue 56, 9 October 2026.
A previously unrecognized microprotein, MP104, encoded by ZEB1‐AS1, emerges as a critical driver of colorectal cancer progression. MP104 links ubiquitin‐mediated protein degradation with translational reprogramming via the UBE2O–AMPKα2–mTOR–EIF4B axis, revealing an unrecognized layer of oncogenic regulation.
Fang Chen, Miao Wang, Hongmei Yong, Jin Ding, Shiping Xu, Qirui Ge, Yan Wang, Lei Zhang, Qianqian Xiao, Benli Li, Li Lin, Sufang Chu, Qianqing Wang, Jin Bai, Pingfu Hou   +14 more
wiley   +1 more source

SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port‐Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways

Advanced Science, Volume 13, Issue 57, 14 October 2026.
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen, Bin Sun, Yajing Qiu, Chen Hua, Xiaoxi Lin, Wei Gao   +5 more
wiley   +1 more source

Comparative Evaluation of Public Data Sets on Average House Prices in Poland

Folia Oeconomica Stetinensia
Access to official information on the real estate market, backed by the authority of public institutions, in particular on average housing prices, is an important element of the real estate market regime.
Kokot Sebastian
doaj   +1 more source

USP25 stabilises GLI1 through K48‐linked deubiquitination within a reciprocal regulatory circuit in osteoarthritis models

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
GLI1‐centred USP25‐GLI1 reciprocal regulation in OA‐relevant models. Hedgehog/GLI1 signalling transcriptionally reinforces USP25 expression, while USP25 deubiquitinates and stabilises GLI1. This reciprocal circuit is associated with inflammatory and cartilage‐catabolic changes in the tested models.
Qian Zhang, Yinyan Ye, Yijie Huang, Jun Li, Dongfeng Huang   +4 more
wiley   +1 more source

Total monomeric anthocyanin concentration estimation of red wines based on color data using multivariate statistical analysis and machine learning

Journal of the Science of Food and Agriculture, Volume 106, Issue 13, Page 7958-7967, October 2026.
Abstract BACKGROUND Red wine is a high‐value grape derivative containing complex chemical compounds that dictate its quality. Qualitative and quantitative determination of these compounds is essential for standardizing and classifying the product. This proof‐of‐concept study integrates chemometric methods and machine learning algorithms to establish ...
Emirhan Atlayan, Berkay Berk, Sevcan Unluturk   +2 more
wiley   +1 more source

Cloning and Purification of Bacteriophage K11 RNA Polymerase [PDF]

BioTechniques, 1999
Minqing Rong, Ray Castagna, William T. McAllister   +2 more
openaire   +3 more sources

A family of E3 ligases extend K11 polyubiquitin on sites of MARUbylation

Abstract Ubiquitin (Ub) cooperation with other post-translational modifications provides a tiered opportunity for protein regulation. Small modifications to Ub such as phosphorylation, acetylation, or ADP-ribosylation have varying impacts on signaling.
Rachel E Lacoursiere, Kapil Upadhyaya, Jasleen Kaur Sidhu, Daniel S Bejan, Ivan Rodriguez Siordia, Michael S Cohen, Jonathan N Pruneda   +6 more
openaire   +2 more sources

TRIM28 Increases RFC4 Protein Expression to Promote Triple‐Negative Breast Cancer Progression

MedComm, Volume 7, Issue 10, October 2026.
RFC4 dysregulation has been implicated in tumor progression and poor prognosis across multiple cancer types. Triple‐negative breast cancer (TNBC) is an aggressive breast cancer subtype with limited therapeutic options and unfavorable clinical outcomes, highlighting the need to identify effective therapeutic targets.
Cheng Guo, Li Liu, Lixiang Sun, Litong Liu, Han Wei, Yutong Yan, Fei Yu, Guangming Fu, Xianning Dong, Ceshi Chen, Chengqin Wang   +10 more
wiley   +1 more source

A significant distinct free energy landscape of K11-diUb from that of K48-diUb.

, 2014
(A) Free energy profiles as a function of and RMSD from the X-ray structure of the closed form of K48-diUb (). (B) Free energy profiles as a function of and RMSD from the X-ray structure of the compact form of K11-diUb (). (C) Free energy profiles as a
Erkang Wang (81595), Chun Tang (169930), Jin Wang (29560), Yong Wang (12837)   +3 more
core   +1 more source

A Noncanonical Protein Degradation Pathway That Regulates Germ Cell Maintenance

Cell Proliferation, Volume 59, Issue 10, October 2026.
SENP8 regulates a non‐canonical NEDD8‐dependent pathway to stabilize STAT1, promote CCL2/CCL5 transcription, and maintain germ cell proliferation and migration.
Meng Liu, Xiya Qiu, Wenying Qu, Yue Ma, Mingyuan Bao, Yuxuan Feng, Xiaochu Wang, Tao Zhou, Bo Zheng, Shunyu Hou, Yu Xia, Qingxia Meng   +11 more
wiley   +1 more source