Results 161 to 170 of about 169,777 (262)

Thermodynamic Basis of Paton's Rate Theory of Drug Action: Occupation Theory as Its Steady-State Limit. [PDF]

Cureus
Raffa RB.
europepmc   +1 more source

Reflections in K2

, 2011
In this thesis we show a reflection theorem for K2. We compare the 3-rank of K2 of the ring of integers of ℚ(√-3D) to the 3-rank of K2 of the ring of integers of ℚ(√-3D) and find that they differ by at most 2. We also show by examples that the formula we obtain is optimal.
openaire   +1 more source

Kinetic Model for Describing the Spring Effect and Incomplete Dissolution in Low-Solubility Drug Formulations Based on the Quality-by-Design (QbD) Approach. [PDF]

Pharmaceutics
Orosz LI, Fábián I, Kalmár J.
europepmc   +1 more source

Coordinating Mesopore Geometry and Interfacial Water Dynamics for Iron‐Site Evolution in Nitrate Electroreduction

Angewandte Chemie, EarlyView.
Mesopore geometry programs the working‐state interface of Fe single sites during nitrate electroreduction. Hexagonal channels reorganize interfacial water and accompany the reversible evolution of isolated Fe─O4‐like sites toward Fe─O─Fe‐like motifs, promoting successive hydrogenation toward NH3 with a Faradaic efficiency of 99.1%.
Xiangyang Liu, Yingji Zhao, Norman C.‐R. Chen, Kevin C.‐W. Wu, Ho Ngoc Nam, Quan Manh Phung, Asep Sugih Nugraha, Yusuke Asakura, Yusuke Yamauchi   +8 more
wiley   +2 more sources

Accessibility and Alignment of Trans‐Cleavage Substrates Modulate the Kinetics of Cas12a Ribonucleoprotein

Angewandte Chemie, EarlyView.
Two key binding events that collectively determine the catalytic efficiency of trans‐cleavage: (1) the substrate passing through the gap between the REC and NUC domains, determined by Kpass, and (2) the alignment of the substrate with the catalytic triad of the ribonucleoprotein, determined by Kalign.
Jianyu Hu, Wei Feng, Hongquan Zhang, X. Chris Le   +3 more
wiley   +2 more sources

First chromosome-scale genome of Cornus kousa K2‡. [PDF]

G3 (Bethesda)
Mehler TPH, Boggess SL, Nowicki M, Hadziabdic D, Shoemaker D, Trigiano RN, Klingeman WE, Molnar TJ, Simpson SA, Youngblood RC, Hulse-Kemp AM, Scheffler BE, Staton ME.   +12 more
europepmc   +1 more source

Synthese einer Stabilen, Hydrophilen Trans‐Cycloocten‐Aminosäure Ermöglicht Schnelle Bioorthogonale Klick‐Chemie zur Herstellung von Antikörper‐Wirkstoffkonjugaten Mittels Erweiterung des Genetischen Codes

Angewandte Chemie, EarlyView.
Es wird von einer neuen trans‐Cycloocten (TCO) basierten nicht‐kanonischen Aminosäure (ncAA) berichtet, die von einer hohen Hydrophilizität und bemerkenswerter Stabilität gegen trans‐cis‐Isomerisierung charakterisiert ist. Der Einbau dieser mittels Erweiterung des genetischen Codes in einen Antikörper und nachfolgende Konjugation erzeugte ein ...
Georgi R. Genov, Dina Osmanović, Ines Bašić, Christine Koehler, Paul F. Sauter   +4 more
wiley   +1 more source

NHC‐Copper(I)‐Mediated Functionalization of White Phosphorus

Angewandte Chemie, EarlyView.
White phosphorus is functionalized by N‐heterocyclic carbene supported copper(I) complexes through redox‐neutral steps. Treatment of the resulting complexes with electrophiles releases the ligands from the metal center as asymmetrically substituted organophosphorus butterfly compounds.
Thomas M. Horsley Downie, Sophia A. Vogler, Gábor Balázs, Francesco Cirigliano, Robert Wolf   +4 more
wiley   +2 more sources

Dietary Vitamin K2 Isoforms Restore Redox Balance, Organelle Integrity, and Genomic Stability under Streptozotocin-Induced Oxidative Stress in Differentiated SH-SY5Y Cells. [PDF]

J Agric Food Chem
Shandilya S, Ruokolainen J.
europepmc   +1 more source

Grenzflächen‐Synergie zwischen Mn und Kohlenstoffnitrid ermöglicht die selektive photokatalytische C–H‐Chlorierung mittels Einzelatomkatalyse

Angewandte Chemie, EarlyView.
Ein Mangan‐Einzelatom‐Photokatalysator auf funktionalisiertem Kohlenstoffnitrid ermöglicht die selektive, durch sichtbares Licht angetriebene C(sp2)–H‐Chlorierung. DFT‐gestützte mechanistische Untersuchungen zeigen, dass die photoinduzierte Ladungstrennung NCS aktiviert, während isolierte Mn‐Zentren Mn–Cl‐Intermediate an der Katalysatorgrenzfläche ...
Jaro Vanderghinste, Prakash Kumar Sahoo, Xinbang Wu, Thanh Huyen Vuong, Anna Rokicińska, Susanna Monti, Giovanni Barcaro, Alina Skorynina, Aleksander Jaworski, Vivien Michaelis, Jabor Rabeah, Julia Bornhorst, Laura Simonelli, Piotr Kuśtrowski, Adam Slabon, Paul J. Dyson, Shoubhik Das   +16 more
wiley   +1 more source