Results 101 to 110 of about 352,958 (260)

Inflammation alters cation chloride cotransporter expression in sensory neurons

Neurobiology of Disease, 2004
Cation chloride cotransporters have been proposed to play a role in the modulation of neuronal responses to γ-aminobutyric acid (GABA). In conditions of neuronal damage, where neuronal excitability is increased, the expression of the KCC2 transporter is ...
Begonia M. Morales-Aza, Naomi L. Chillingworth, John A. Payne, Lucy F. Donaldson   +3 more
doaj  

Molecular insights into the normal operation, regulation, and multisystemic roles of K+-Cl- cotransporter 3 (KCC3).

American Journal of Physiology - Cell Physiology, 2017
Long before the molecular identity of the Na+-dependent K+-Cl- cotransporters was uncovered in the mid-nineties, a Na+-independent K+-Cl- cotransport system was also known to exist. It was initially observed in sheep and goat red blood cells where it was
A. P. Garneau, A. Marcoux, R. Frenette‐Cotton, F. Mac-Way, J. Lavoie, P. Isenring   +5 more
semanticscholar   +1 more source

Cancer therapy‐related cardiotoxicity is associated with distinct alterations of the myocardial lipidome

European Journal of Heart Failure, EarlyView.
Lipidome changes in anthracycline‐induced cardiotoxicity (AIC). Aims Anthracyclines are key components of various chemotherapy regimens, but their clinical utility is limited by severe cardiotoxic side effects. Previous studies have suggested that anthracycline‐induced cardiotoxicity (AIC) may be driven by alterations in myocardial lipid metabolism ...
Vera M. Braun, Anna Foryst‐Ludwig, Ulf Landmesser, István Baczkó, Hendrik Milting, Ulrich Kintscher, Niklas Beyhoff   +6 more
wiley   +1 more source

Synopsis of the 48th Annual Meeting of the Lake Cumberland Biological Transport Group and the Second Biannual Meeting of the Pendrin Consortium

Cellular Physiology and Biochemistry, 2013
Ion transporters are the molecular basis for ion homeostasis of the cell and the whole organism. The anion exchanger pendrin is only one of a number of examples where a complete or partial loss of function and/or deregulation of expression of ion ...
Silvia Dossena, Charity Nofziger, Rossana Morabito, Norma C. Adragna, Markus Paulmichl   +4 more
doaj   +1 more source

Off-Label Use of Bumetanide for Brain Disorders: An Overview

Frontiers in Neuroscience, 2019
Bumetanide (BTN or BUM) is a FDA-approved potent loop diuretic (LD) that acts by antagonizing sodium-potassium-chloride (Na-K-Cl) cotransporters, NKCC1 (SLc12a2) and NKCC2.
Shivani C. Kharod, Seok Kyu Kang, Shilpa D. Kadam, Shilpa D. Kadam   +3 more
doaj   +1 more source

Initiation of bivalve shell calcification under ocean acidification: integrating insights from shell to cell

Limnology and Oceanography Letters, EarlyView.
Abstract The formation of initial bivalve shell is sensitive to ocean acidification, encoding the basis of shell formation and environmental information. Here, we demonstrated how the initial shell building processes were affected under various acidified conditions.
Yang Xu, Fortunatus Masanja, Yuewen Deng, Yong Liu, Liqiang Zhao   +4 more
wiley   +1 more source

Li doping kagome spin liquid compounds [PDF]

, 2017
Herbertsmithite and Zn-doped barlowite are two compounds for experimental realization of twodimensional gapped kagome spin liquid. Theoretically, it has been proposed that charge doping a quantum spin liquid gives rise to exotic metallic states, such as high-temperature superconductivity.
arxiv   +1 more source

A glial K+/Cl− cotransporter modifies temperature‐evoked dynamics in Caenorhabditis elegans sensory neurons

Genes, Brain and Behavior, 2015
K+/Cl− cotransporters (KCCs) are known to be crucial in the control of neuronal electrochemical Cl− gradient. However, the role of these proteins in glial cells remains largely unexplored despite a number of studies showing expression of KCC proteins in ...
Atsushi Yoshida, Shunji Nakano, Takamasa Suzuki, Takamasa Suzuki, Kunio Ihara, Tetsuya Higashiyama, Ikue Mori   +6 more
semanticscholar   +1 more source

Comparative Proteomics of Salinity Stress Responses in Fish and Aquatic Invertebrates

PROTEOMICS, EarlyView.
ABSTRACT Fluctuating salinity is symptomatic of climate change challenging aquatic species. The melting of polar ice, rising sea levels, coastal surface and groundwater salinization, and increased evaporation in arid habitats alter salinity worldwide. Moreover, the frequency and intensity of extreme weather events such as rainstorms and floods increase,
Maxime Leprêtre, Jens Hamar, Monica B. Urias, Dietmar Kültz   +3 more
wiley   +1 more source

Canonical Bcl-2 Motifs of the Na+/K+ Pump Revealed by the BH3 Mimetic Chelerythrine: Early Signal Transducers of Apoptosis?

Cellular Physiology and Biochemistry, 2013
Background/Aims: Chelerythrine [CET], a protein kinase C [PKC] inhibitor, is a prop-apoptotic BH3-mimetic binding to BH1-like motifs of Bcl-2 proteins.
Peter K. Lauf, Judith Heiny, Jarek Meller, Michael A. Lepera, Leonid Koikov, Gerald M. Alter, Thomas L. Brown, Norma C. Adragna   +7 more
doaj   +1 more source