Results 131 to 140 of about 6,975 (268)
Renal potassium handling in rats with subtotal nephrectomy: modeling and analysis [PDF]
, 2018 We sought to decipher the mechanisms underlying the kidney's response to changes in K+ load and intake, under physiological and pathophysiological conditions.
Edwards, Aurelie +2 more
core +1 more source
Targeting Adipose Tissue Function Protects Against Heart Failure with Preserved Ejection Fraction
Advanced Science, Volume 13, Issue 7, 3 February 2026.This study explores the role adipose tissue (AT) phenotypes have in determining cardiovascular outcomes in an obesity‐related heart failure with preserved ejection fraction (HFpEF) model. Pharmacological induction of thermogenesis promoted resilience to HFpEF‐induced remodeling of AT and conferred cardioprotection. Surgical and genetic models confirmed
Jordan Jousma +11 more
wiley +1 more source
Spinal NKCC1 blockade inhibits TRPV1-dependent referred allodynia
Molecular Pain, 2007 Background The Na+, K+, 2Cl- type I cotransporter (NKCC1) and TRPV1 receptors, at the level of the dorsal horn, have been implicated in mediating allodynia in response to an inflammatory insult.
Cervero Fernando +3 more
doaj +1 more source
Gitelman and Bartter Syndrome in a Patient With Morbid Obesity: A Case Report and Literature Review
Clinical Case Reports, Volume 14, Issue 2, February 2026.ABSTRACT We present a case study of a 34‐year‐old man with morbid obesity and a suspected Bartter–Gitelman spectrum tubulopathy (without genetic confirmation), weighing 135 kg, and with a BMI of 42.5 kg/m2, who was referred to the metabolic and bariatric surgery department due to morbid obesity to address abnormal electrolyte levels.
Solmaz Hasani +4 more
wiley +1 more source
Generation of Mice Harboring Bicc1 Conditional Null Alleles
genesis, Volume 64, Issue 1, February 2026.ABSTRACT Bicaudal C1 (Bicc1) encodes an RNA‐binding protein critical for many organ development and epithelial tissue homeostasis. Bicc1 null mutations have been shown to lead to the development of polycystic kidney disease (PKD) and death at an early prenatal stage.
Chia‐Feng Liu +4 more
wiley +1 more source
Diabetes, Obesity and Metabolism, Volume 28, Issue 2, Page 1304-1314, February 2026.Abstract Aim PIONEER REAL Saudi Arabia investigated real‐world clinical outcomes associated with the use of once‐daily oral semaglutide in adults with type 2 diabetes (T2D). Materials and Methods This was a 34‐ to 44‐week multicentre, prospective, open‐label study in adults with T2D, who were treatment‐naive to injectable glucose‐lowering medication ...
Hussein ElBadawi +11 more
wiley +1 more source
Functional characterization of NRT1/PTR FAMILY transporters: looking for a needle in a haystack
New Phytologist, Volume 249, Issue 3, Page 1124-1144, February 2026.Summary NRT1/PTR FAMILY (NPF) transporters play crucial roles in plant physiology and development due to their involvement in nitrogen nutrition and their ability to transport multiple signaling molecules and metabolites. Whereas most eukaryotic and prokaryotic NPF orthologs are peptide transporters, most flowering plant NPF transport other substrates ...
Laura Morales de Los Ríos +6 more
wiley +1 more source
Structural basis for human NKCC1 inhibition by loop diuretic drugs
The EMBO JournalNa+–K+–Cl− cotransporters functions as an anion importers, regulating trans-epithelial chloride secretion, cell volume, and renal salt reabsorption. Loop diuretics, including furosemide, bumetanide, and torsemide, antagonize both NKCC1 and NKCC2, and are
Yongxiang Zhao +6 more
doaj +1 more source
Functional Comparison of the K+-Cl−Cotransporters KCC1 and KCC4 [PDF]
, 2000 Adriana Mercado +4 more
openalex +1 more source
Integrated K + channel and K + -Cl − cotransporter functions regulate fin proportionality in zebrafish [PDF]
, 2019 Jennifer Lanni +9 more
openalex +1 more source