Results 11 to 20 of about 352,958 (260)

Comparison of Na-K-Cl Cotransporters [PDF]

Journal of Biological Chemistry, 1998
The Na-K-Cl cotransporter (NKCC) mediates the coupled movement of ions into most animal cells, playing important roles in maintenance of cell volume and in epithelial Cl transport.
P. Isenring, S. Jacoby, J. A. Payne, B. Forbush   +3 more
semanticscholar   +4 more sources

Exon loss accounts for differential sorting of Na-K-Cl cotransporters in polarized epithelial cells. [PDF]

Mol Biol Cell, 2008
The renal Na-K-Cl cotransporter (NKCC2) is selectively expressed in the apical membranes of cells of the mammalian kidney, where it is the target of the clinically important loop diuretics. In contrast, the "secretory" NKCC1 cotransporter is localized in
Carmosino M, Giménez I, Caplan M, Forbush B.   +3 more
europepmc   +2 more sources

A Dominant Negative Mutant of the KCC1 K-Cl Cotransporter [PDF]

Journal of Biological Chemistry, 2001
K-Cl cotransport regulates cell volume and chloride equilibrium potential. Inhibition of erythroid K-Cl cotransport has emerged as an important adjunct strategy for the treatment of sickle cell anemia. However, structure-function relationships among the polypeptide products of the four K-Cl cotransporter (KCC) genes are little understood.
Sabina Casula, Boris E. Shmukler, Sabine Wilhelm, Alan K. Stuart-Tilley, Wanfang Su, Marina N. Chernova, Carlo Brugnara, Seth L. Alper   +7 more
openalex   +6 more sources

Cation-Chloride Cotransporters KCC2 and NKCC1 as Therapeutic Targets in Neurological and Neuropsychiatric Disorders

Molecules, 2023
Neurological diseases including Alzheimer’s, Huntington’s disease, Parkinson’s disease, Down syndrome and epilepsy, and neuropsychiatric disorders such as schizophrenia, are conditions that affect not only individuals but societies on a global scale ...
Patricia Lam, Julia Newland, Richard L. M. Faull, Andrea Kwakowsky   +3 more
doaj   +2 more sources

Disruption of erythroid K-Cl cotransporters alters erythrocyte volume and partially rescues erythrocyte dehydration in SAD mice. [PDF]

J Clin Invest, 2007
K-Cl cotransport activity in rbc is a major determinant of rbc volume and density. Pathologic activation of erythroid K-Cl cotransport activity in sickle cell disease contributes to rbc dehydration and cell sickling.
Rust MB, Alper SL, Rudhard Y, Shmukler BE, Vicente R, Brugnara C, Trudel M, Jentsch TJ, Hübner CA.   +8 more
europepmc   +2 more sources

The K-Cl cotransporter-3 in the mammalian kidney. [PDF]

Curr Opin Nephrol Hypertens, 2023
Purpose of review We recently localized a new K–Cl cotransporters-3 (KCC3) transporter to the apical membrane of type-B intercalated cells. This gives us an opportunity to revisit the roles of the KCC3 in kidney and integrate the new findings to our current knowledge of the biology of the bicarbonate secreting cells.
Ferdaus MZ, Delpire E.
europepmc   +3 more sources

Regulated phosphorylation of the K-Cl cotransporter KCC3 at dual C-terminal threonines is a potent switch of intracellular potassium content and cell volume homeostasis

Frontiers in Cellular Neuroscience, 2015
The defense of cell volume against excessive shrinkage or swelling is a requirement for cell function and organismal survival. Cell swelling triggers a coordinated homeostatic response termed regulatory volume decrease (RVD), resulting in K+ and Cl ...
Norma C. Adragna, Nagendra Babu Ravilla, Peter K. Lauf, Peter K. Lauf, Gulnaz eBegum, Arjun R. Khanna, Dandan eSun, Dandan eSun, Kristopher T Kahle, Kristopher T Kahle   +9 more
doaj   +2 more sources

Evidence for K‐Cl cotransporter heterodimerization

The FASEB Journal, 2012
In humans, mutations in the gene SLC12A6 which encodes for KCC3 result in an autosomal recessive disease, known as ACCPN (Agenesis of the Corpus Callosum associated with Peripheral Neuropathy). In the present work we focused our efforts in understanding the lethality demonstrated by the homozygosity of the Glu289Gly (E289G) mutation in the mouse K‐Cl ...
José Ponce‐Coria, Jinlong Ding, E. Delpire   +2 more
semanticscholar   +2 more sources

Molecular Characterization of a Putative K-Cl Cotransporter in Rat Brain [PDF]

Journal of Biological Chemistry, 1996
Using a combination of data base searching, polymerase chain reaction, and library screening, we have identified a putative K-Cl cotransporter isoform (KCC2) in rat brain that is specifically localized in neurons.
J. A. Payne, Tamara J. Stevenson, L. Donaldson   +2 more
semanticscholar   +2 more sources

Expression of K +-Cl - cotransporters in the α-cells of rat endocrine pancreas

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2004
The expression of K+-Cl- cotransporters (KCC) was examined in pancreatic islet cells. mRNA for KCC1, KCC3a, KCC3b and KCC4 were identified by RT-PCR in islets isolated from rat pancreas. In immunocytochemical studies, an antibody specific for KCC1 and KCC4 revealed the expression of KCC protein in alpha-cells, but not pancreatic beta-cells nor delta ...
Sarah L. Davies, E. Roussa, Philippe Le Rouzic, F. Thévenod, Seth L. Alper, Len Best, P. Brown   +6 more
semanticscholar   +5 more sources