Results 11 to 20 of about 50 (50)

Coordinate modulation of Na-K-2Cl cotransport and K-Cl cotransport by cell volume and chloride [PDF]

American Journal of Physiology-Cell Physiology, 2002
Na-K-2Cl cotransporter (NKCC) and K-Cl cotransporter (KCC) play key roles in cell volume regulation and epithelial Cl− transport. Reductions in either cell volume or cytosolic Cl− concentration ([Cl−]i) stimulate a corrective uptake of KCl and water via NKCC, whereas cell swelling triggers KCl loss via KCC.
Christian Lytle, Thomas J. McManus
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Phosphoregulation of the Na–K–2Cl and K–Cl cotransporters by the WNK kinases

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2010
Precise regulation of the intracellular concentration of chloride [Cl-]i is necessary for proper cell volume regulation, transepithelial transport, and GABA neurotransmission. The Na-K-2Cl (NKCCs) and K-Cl (KCCs) cotransporters, related SLC12A transporters mediating cellular chloride influx and efflux, respectively, are key determinants of [Cl-]i in ...
Richard P. Lifton, Jesse Rinehart, Kristopher T. Kahle   +2 more
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Sites of Regulated Phosphorylation that Control K-Cl Cotransporter Activity [PDF]

Cell, 2009
Modulation of intracellular chloride concentration ([Cl(-)](i)) plays a fundamental role in cell volume regulation and neuronal response to GABA. Cl(-) exit via K-Cl cotransporters (KCCs) is a major determinant of [Cl(-)](I); however, mechanisms governing KCC activities are poorly understood.
Biff Forbush, Jesse Rinehart, Clinton H. Joiner, Yelena Maksimova, Patrick G. Gallagher, Erol E. Gulcicek, Dianqing Wu, Caleb A. Hodson, Weijun Pan, Kathryn L. Stone, Junhui Zhang, Jessica E. Tanis, Richard P. Lifton, Mary Risinger, Christopher M. Colangelo   +14 more
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A Dominant Negative Mutant of the KCC1 K-Cl Cotransporter [PDF]

Journal of Biological Chemistry, 2001
K-Cl cotransport regulates cell volume and chloride equilibrium potential. Inhibition of erythroid K-Cl cotransport has emerged as an important adjunct strategy for the treatment of sickle cell anemia. However, structure-function relationships among the polypeptide products of the four K-Cl cotransporter (KCC) genes are little understood.
Seth L. Alper, Sabina Casula, Sabine Wilhelm, Marina N. Chernova, Alan K. Stuart-Tilley, Boris E. Shmukler, Wanfang Su, Carlo Brugnara, Carlo Brugnara   +8 more
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K-Cl cotransporters, cell volume homeostasis, and neurological disease [PDF]

Trends in Molecular Medicine, 2015
K(+)-Cl(-) cotransporters (KCCs) were originally characterized as regulators of red blood cell (RBC) volume. Since then, four distinct KCCs have been cloned, and their importance for volume regulation has been demonstrated in other cell types. Genetic models of certain KCCs, such as KCC3, and their inhibitory WNK-STE20/SPS1-related proline/alanine-rich
Kahle, Kristopher K., Khanna, Arjun R., Alper, Seth L., Adragna, Norma C., Lauf, Peter K., Sun, Dandan, Delpire, Eric   +6 more
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Chemical crosslinking studies with the mouse Kcc1 K–Cl cotransporter [PDF]

Blood Cells, Molecules, and Diseases, 2009
Oligomerization, function, and regulation of unmodified mouse Kcc1 K-Cl cotransporter were studied by chemical crosslinking. Treatment of Xenopus oocytes and 293T cells expressing K-Cl cotransporter Kcc1 with several types of chemical cross-linkers shifted Kcc1 polypeptide to higher molecular weight forms. More extensive studies were performed with the
Alexander S. Zolotarev, Alexander S. Zolotarev, Alan K. Stuart-Tilley, Sabine Wilhelm, Sabina Casula, Carlo Brugnara, Carlo Brugnara, Boris E. Shmukler, Seth L. Alper, Seth L. Alper   +9 more
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Current view on the functional regulation of the neuronal K+-Cl− cotransporter KCC2 [PDF]

Frontiers in Cellular Neuroscience, 2014
In the mammalian central nervous system (CNS), the inhibitory strength of chloride (Cl(-))-permeable GABAA and glycine receptors (GABAAR and GlyR) depends on the intracellular Cl(-) concentration ([Cl(-)]i). Lowering [Cl(-)]i enhances inhibition, whereas raising [Cl(-)]i facilitates neuronal activity.
Pavel Uvarov, Igor Medina, Igor Medina, Claudio Rivera, Claudio Rivera, Claudio Rivera, Nazim Kourdougli, Nazim Kourdougli, Christophe Pellegrino, Christophe Pellegrino, Kristopher T. Kahle, Kristopher T. Kahle, Perrine Friedel, Perrine Friedel   +13 more
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Modulation of neuronal activity by phosphorylation of the K–Cl cotransporter KCC2 [PDF]

Trends in Neurosciences, 2013
The K-Cl cotransporter KCC2 establishes the low intraneuronal Cl- levels required for the hyperpolarizing inhibitory postsynaptic potentials mediated by ionotropic γ-aminobutyric acid receptors (GABAARs) and glycine receptors (GlyRs). Decreased KCC2-mediated Cl- extrusion and impaired hyperpolarizing GABAAR- and/or GlyR-mediated currents have been ...
Kristopher T. Kahle, Kristopher T. Kahle, Kai Kaila, Liliya Silayeva, Stephen J. Moss, Stephen J. Moss, Martin Puskarjov, Tarek Z. Deeb, Bo Liang   +8 more
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K⁺‐Cl⁻ cotransport: ‘to be or not to be’ oxygen sensitive

The Journal of Physiology, 1998
Under 20 years ago, K+-Cl− cotransport (Cot) was discovered in red blood cells after hyposmotic cell swelling (Dunham & Ellory, 1981) and cellular thiol modification (Lauf & Theg, 1980), and later shown to be electroneutral (Kaji, 1993; Lauf & Adragna, 1996).
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Na/K/Cl cotransport in cultured human fibroblasts.

Journal of Biological Chemistry, 1985
The transport characteristics and regulation of the Na/K/Cl cotransport system were investigated in cultured human fibroblasts (HSWP cells). The existence of the system was documented by the finding that digitoxin-insensitive K+ influx was dependent upon the presence of both Na+ and Cl- in the extracellular milieu.
M L Prastein, N E Owen
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