Results 11 to 20 of about 6,975 (268)

Striatal Chloride Dysregulation and Impaired GABAergic Signaling Due to Cation-Chloride Cotransporter Dysfunction in Huntington’s Disease

Frontiers in Cellular Neuroscience, 2022
Intracellular chloride (Cl–) levels in mature neurons must be tightly regulated for the maintenance of fast synaptic inhibition. In the mature central nervous system (CNS), synaptic inhibition is primarily mediated by gamma-amino butyric acid (GABA ...
Melissa Serranilla, Melanie A. Woodin
doaj   +1 more source

Role of the cation-chloride-cotransporters in the circadian system

Asian Journal of Pharmaceutical Sciences, 2021
The circadian system plays an immense role in controlling physiological processes in our body. The suprachiasmatic nucleus (SCN) supervises this system, regulating and harmonising the circadian rhythms in our body.
Shihan Salihu, Nur Farah Meor Azlan, Sunday Solomon Josiah, Zhijuan Wu, Yun Wang, Jinwei Zhang   +5 more
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Homooligomeric and Heterooligomeric Associations between K+-Cl– Cotransporter Isoforms and between K+-Cl– and Na+-K+-Cl– Cotransporters [PDF]

Journal of Biological Chemistry, 2007
Little is known regarding the quaternary structure of cation-Cl- cotransporters (CCCs) except that the Na+-dependent CCCs can exist as homooligomeric units. Given that each of the CCCs exhibits unique functional properties and that several of these carriers coexist in various cell types, it would be of interest to determine whether the four K+-Cl ...
Charles F, Simard, Marc J, Bergeron, Rachelle, Frenette-Cotton, Gabriel A, Carpentier, Marie-Eve, Pelchat, Luc, Caron, Paul, Isenring   +6 more
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Role of the Cation-Chloride-Cotransporters in Cardiovascular Disease

Cells, 2020
The SLC12 family of cation-chloride-cotransporters (CCCs) is comprised of potassium chloride cotransporters (KCCs), which mediate Cl− extrusion and sodium-potassium chloride cotransporters (N[K]CCs), which mediate Cl− loading.
Nur Farah Meor Azlan, Jinwei Zhang
doaj   +1 more source

Characterization of Glial Cell K-Cl Cotransport [PDF]

Cellular Physiology and Biochemistry, 2007
The molecular mechanism of K-Cl cotransport (KCC) consists of at least 4 isoforms, KCC 1, 2, 3, and 4 which, in multiple combinations, exist in most cells, including erythrocytes and neuronal cells.We utilized reverse-transcriptase-polymerase chain reaction (RT-PCR) and ion flux studies to characterize KCC activity in an immortalized in vitro cell ...
Gagnon, Kenneth B. E., Adragna, Norma C., Fyffe, Robert E.W., Lauf, Peter K.   +3 more
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Abnormal expression of cerebrospinal fluid cation chloride cotransporters in patients with Rett Syndrome [PDF]

, 2013
Objective: Rett Syndrome is a progressive neurodevelopmental disorder caused mainly by mutations in the gene encoding methyl-CpG-binding protein 2. The relevance of MeCP2 for GABAergic function was previously documented in animal models. In these models,
Armstrong, Judith, Artuch, Rafael, Duarte, Sofia, Garcia-Cazorla, Angels, Ormazabal, Aida, Ortez, Carlos, O’Callaghan, Maria del Mar, Pereira, Antonina, Perez, Ana, Pineda, Mercedes, Roche, Ana, Sanmarti, Francesc   +11 more
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Inhibition of cAMP-activated intestinal chloride secretion by diclofenac: cellular mechanism and potential application in cholera. [PDF]

PLoS Neglected Tropical Diseases, 2014
Cyclic AMP-activated intestinal Cl- secretion plays an important role in pathogenesis of cholera. This study aimed to investigate the effect of diclofenac on cAMP-activated Cl- secretion, its underlying mechanisms, and possible application in the ...
Pawin Pongkorpsakol, Nutthapoom Pathomthongtaweechai, Potjanee Srimanote, Sunhapas Soodvilai, Varanuj Chatsudthipong, Chatchai Muanprasat   +5 more
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Cell volume regulation in the proximal tubule of rat kidney proximal tubule cell volume regulation [PDF]

, 2017
We developed a dynamic model of a rat proximal convoluted tubule cell in order to investigate cell volume regulation mechanisms in this nephron segment.
Edwards, Aurelie, Layton, Anita T.
core   +1 more source

K-Cl cotransport systems

Kidney International, 1989
The KCl cotransporter in the basolateral membrane of renal tubules may play a central role in the transcellular transport of NaCl. Because this transporter is electrically neutral, and also functions in parallel to the electrogenic Na,K-ATPase, there is an imbalance in charge which must be expressed as a cationic current across the basolateral membrane.
Warnock, David G., Eveloff, Jill
openaire   +2 more sources

Structural Pharmacology of Cation-Chloride Cotransporters

Membranes, 2022
Loop and thiazide diuretics have been cornerstones of clinical management of hypertension and fluid overload conditions for more than five decades. The hunt for their molecular targets led to the discovery of cation-chloride cotransporters (CCCs) that ...
Yongxiang Zhao, Erhu Cao
doaj   +1 more source