Results 21 to 30 of about 6,975 (268)

Leveraging unique structural characteristics of WNK kinases to achieve therapeutic inhibition [PDF]

, 2016
This is the author accepted manuscript. The final version is available from American Association for the Advancement of Science via the DOI in this record.The with-no-lysine (K) WNK kinases are master regulators of the Na+-(K+)-Cl- cotransporters ...
Alessi, J. Zhang, K. T. Kahle, Kahle, Lifton, Min, Shekarabi, Wilson, X. Deng   +8 more
core   +3 more sources

Imbalanced expression of cation-chloride cotransporters as a potential therapeutic target in an Angelman syndrome mouse model

Scientific Reports, 2023
Angelman syndrome is a neurodevelopmental disorder caused by loss of function of the maternally expressed UBE3A gene. Treatments for the main manifestations, including cognitive dysfunction or epilepsy, are still under development.
Kiyoshi Egawa, Miho Watanabe, Hideaki Shiraishi, Daisuke Sato, Yukitoshi Takahashi, Saori Nishio, Atsuo Fukuda   +6 more
doaj   +1 more source

Glial Chloride Homeostasis Under Transient Ischemic Stress

Frontiers in Cellular Neuroscience, 2021
High water permeabilities permit rapid adjustments of glial volume upon changes in external and internal osmolarity, and pathologically altered intracellular chloride concentrations ([Cl–]int) and glial cell swelling are often assumed to represent early ...
Miriam Engels, Manu Kalia, Manu Kalia, Sarah Rahmati, Laura Petersilie, Peter Kovermann, Michel J. A. M. van Putten, Christine R. Rose, Hil G. E. Meijer, Thomas Gensch, Christoph Fahlke   +10 more
doaj   +1 more source

Differential regulation of K⁺-Cl⁻ cotransporter 2 (KCC2) and Na⁺-K⁺-Cl⁻ cotransporter 1 (NKCC1) expression by zolpidem in CA1 and CA3 hippocampal subregions of the lithium-pilocarpine status epilepticus rat model [PDF]

Exp Anim
Muhammad Zulfadhli Othman, Muhammad Haqeem Mohd Nasir, Wan Amir Nizam Wan Ahmad, Jafri Malin Abdullah, Ahmad Tarmizi Che Has   +4 more
openalex   +3 more sources

Balance of Na+, K+, and Cl– Unidirectional Fluxes in Normal and Apoptotic U937 Cells Computed With All Main Types of Cotransporters

Frontiers in Cell and Developmental Biology, 2020
Fluxes of monovalent ions through the multiple pathways of the plasma membrane are highly interdependent, and their assessment by direct measurement is difficult or even impossible.
Valentina E. Yurinskaya, Igor A. Vereninov, Alexey A. Vereninov   +2 more
doaj   +1 more source

Cation-Chloride Cotransporters, Na/K Pump, and Channels in Cell Water and Ion Regulation: In silico and Experimental Studies of the U937 Cells Under Stopping the Pump and During Regulatory Volume Decrease

Frontiers in Cell and Developmental Biology, 2021
Cation-coupled chloride cotransporters play a key role in generating the Cl– electrochemical gradient on the cell membrane, which is important for regulation of many cellular processes.
Valentina E. Yurinskaya, Alexey A. Vereninov   +1 more
doaj   +1 more source

Essential role of CFTR in PKA-dependent phosphorylation, alkalinization, and hyperpolarization during human dperm capacitation [PDF]

, 2017
Mammalian sperm require to spend a limited period of time in the female reproductive tract to become competent to fertilize in a process called capacitation.
Austin, Berger, Bobadilla, Buffone, Buffone, Buffone, Buffone, Chang, Chen, Chen, Chen, Chávez, Chávez, De Jonge, De La Vega-Beltran, Demarco, Diao, Dirami, Dostmann, Ellsworth, Escoffier, Esteves, Figueiras-Fierro, Gabriel, Gadsby, Hernández-González, Ishiguro, José, Kase, Kujala, Köhn, l'Hoste, Laemmli, Leclerc, Li, Lishko, Lochner, Luconi, López-González, Ma, Melis, Mortimer, Muanprasat, Navarrete, Neill, Nishigaki, Nolan, Okamura, Rode, Schulz, Sheppard, Sorum, Stival, Stival, Tabcharani, Tang, Towbin, Visconti, Visconti, Wennemuth, Wertheimer, Xu, Zeng, Zeng   +63 more
core   +1 more source

Cellular mechanisms underlying the inhibitory effect of flufenamic acid on chloride secretion in human intestinal epithelial cells

Journal of Pharmacological Sciences, 2017
Intestinal Cl− secretion is involved in the pathogenesis of secretory diarrheas including cholera. We recently demonstrated that flufenamic acid (FFA) suppressed Vibrio cholerae El Tor variant-induced intestinal fluid secretion via mechanisms involving ...
Pawin Pongkorpsakol, Chantapol Yimnual, Varanuj Chatsudthipong, Vatcharin Rukachaisirikul, Chatchai Muanprasat   +4 more
doaj   +1 more source

Phosphorylation and transport in the Na-K-2Cl cotransporters, NKCC1 and NKCC2A, compared in HEK-293 cells. [PDF]

PLoS ONE, 2011
Na-K-2Cl cotransporters help determine cell composition and volume. NKCC1 is widely distributed whilst NKCC2 is only found in the kidney where it plays a vital role reabsorbing 20% of filtered NaCl.
Anke Hannemann, Peter W Flatman
doaj   +1 more source

Inflammation alters cation chloride cotransporter expression in sensory neurons

Neurobiology of Disease, 2004
Cation chloride cotransporters have been proposed to play a role in the modulation of neuronal responses to γ-aminobutyric acid (GABA). In conditions of neuronal damage, where neuronal excitability is increased, the expression of the KCC2 transporter is ...
Begonia M. Morales-Aza, Naomi L. Chillingworth, John A. Payne, Lucy F. Donaldson   +3 more
doaj   +1 more source