Results 21 to 30 of about 352,958 (260)
Sevoflurane-induced regulation of NKCC1/KCC2 phosphorylation through activation of Spak/OSR1 kinase and cognitive impairment in ischemia-reperfusion injury in rats [PDF]
HeliyonThe occurrence of excitotoxic damage caused by cerebral ischemia-reperfusion (I/R) injury is closely linked to a decrease in central inhibitory function, in which the concentration of chloride inside the cells ([Cl−]i) plays a crucial role.
Yuefeng Wang +5 more
doaj +1 more source
Bio-Protocol, 2021 Cation-chloride cotransporters (CCCs) mediate the coupled, electroneutral symport of cations such as Na+ and/or K+ with chloride across membrane.
Si Liu, Jiangtao Guo
doaj +1 more source
A trafficking-deficient mutant of KCC3 reveals dominant-negative effects on K-Cl cotransport function. [PDF]
PLoS ONE, 2013 The K-Cl cotransporter (KCC) functions in maintaining chloride and volume homeostasis in a variety of cells. In the process of cloning the mouse KCC3 cDNA, we came across a cloning mutation (E289G) that rendered the cotransporter inactive in functional ...
Jinlong Ding +2 more
doaj +1 more source
Nature Communications, 2022 Loop diuretics including bumetanide inhibit Na+-K+-Cl−-cotransporters (NKCCs) and are used for the treatment of edema and hypertension. Here, Zhao et. al.
Yongxiang Zhao +6 more
doaj +1 more source
Interacting electron spins in $κ$-(BEDT-TTF)$_2$Cu[N(CN)$_2$]I investigated by ESR spectroscopy [PDF]
Physical Review B 102, 214430 (2020), 2021 We performed angular and temperature-dependent electron-spin-resonance measurements in the quasi-two-dimensional organic conductor $\kappa$-(BEDT-TTF)$_2$Cu[N(CN)$_2$]I. The interlayer spin-diffusion is much weaker compared to the Cl- and Br-analogues, which are antiferromagnetic insulator and paramagnetic metal, respectively; $\kappa$-(BEDT-TTF)$_2$Cu[
arxiv +1 more source
Advances in the pathogenesis of Rett syndrome using cell models
Animal Models and Experimental Medicine, Volume 5, Issue 6, Page 532-541, December 2022., 2022 Most Rett syndrome (RTT) patients are affected by the MECP2 gene mutations. And the mutations of MECP2 have wide effects on different cell types of nervous system, including neurons, astrocytes, oligodendrocytes and microglia, which always combined together to lead to abnormalities in the whole neural network.
Sijia Lu, Yongchang Chen, Zhengbo Wang
wiley +1 more source
Decreased chloride channel expression in the dorsolateral prefrontal cortex in schizophrenia. [PDF]
PLoS ONE, 2015 Alterations in GABAergic neurotransmission are implicated in several psychiatric illnesses, including schizophrenia. The Na-K-Cl and K-Cl cotransporters regulate intracellular chloride levels.
Courtney R Sullivan +4 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2022 Intracellular chloride (Cl–) levels in mature neurons must be tightly regulated for the maintenance of fast synaptic inhibition. In the mature central nervous system (CNS), synaptic inhibition is primarily mediated by gamma-amino butyric acid (GABA ...
Melissa Serranilla, Melanie A. Woodin
doaj +1 more source
Role of the Cation-Chloride-Cotransporters in Cardiovascular Disease
Cells, 2020 The SLC12 family of cation-chloride-cotransporters (CCCs) is comprised of potassium chloride cotransporters (KCCs), which mediate Cl− extrusion and sodium-potassium chloride cotransporters (N[K]CCs), which mediate Cl− loading.
Nur Farah Meor Azlan, Jinwei Zhang
doaj +1 more source
J = 0 nonmagnetic insulating state in K$_2$Os$X_6$ (X = F, Cl and Br) [PDF]
Phys. Rev. B 106, 155148 (2022), 2022 In $4d/5d$ transition-metal systems, many interesting physical properties arise from the interplay of bandwidth, electronic correlations, and spin-orbit interactions. Here, using {\it ab initio} density functional theory, we systematically study the double-perovskite-like system K$_2$Os$X_6$ (X = F, Cl, and Br) with a $5d^4$ electronic configuration ...
arxiv +1 more source