Results 241 to 250 of about 5,024,889 (297)
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3H-kainic acid binding: Relevance for evaluating the neurotoxicity of kainic acid
Life Sciences, 1979Abstract Binding of 3 H-kainic acid (KA) to brain membranes is saturable (K D = 72 nM) and displays markes specificity for compounds that bear relation to excitatory amino acids. Its regional distribution correlates roughly with the regional neurotoxicity of in situ KA injections. Striatal kainate lesions, but not interruption of striatal afferents,
Kjell Fuxe, Robert Schwarcz
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Clinical and Experimental Pharmacology and Physiology, 2019
Temporal lobe epilepsy (TLE) is one of the most prevalent types of epilepsy in human. Huperzine A (Hup‐A) has been reported to possess antioxidative and anti‐inflammatory properties; however, its role in TLE induced by kainic acid has not been determined.
Parvaneh Mohseni-Moghaddam +7 more
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Temporal lobe epilepsy (TLE) is one of the most prevalent types of epilepsy in human. Huperzine A (Hup‐A) has been reported to possess antioxidative and anti‐inflammatory properties; however, its role in TLE induced by kainic acid has not been determined.
Parvaneh Mohseni-Moghaddam +7 more
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Photostability of Kainic Acid in Seawater
Journal of Agricultural and Food Chemistry, 2007The environmental degradation of a mixture of domoic acid (DA) and kainic acid (KA) in seawater with and without added transition metals is reported. The association constants for kainic acid with Fe (III) and Cu (II) were determined using (1)H nuclear magnetic resonance (NMR; K1,Fe(III) = 2.27 x 10(12), K2,Fe(III) = 8.99 x 10(8), K1,Cu(II) = 1.38 x 10(
Peter D. R. Moeller +4 more
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The mechanism of kainic acid neurotoxicity
Nature, 1983The putative excitatory transmitters glutamate and aspartate, as well as their excitatory analogues, can kill neurones in the central nervous system and may thus be involved in the pathogenesis of various neurodegenerative disorders. Several studies have suggested that postsynaptic receptors are important in the mechanism of toxicity.
John Garthwaite, Giti Garthwaite
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Kainic acid neurotoxicity and seizures
Neuropharmacology, 1981Abstract The effects of anesthetics and anticonvulsants on the neurotoxic effects of kainic acid (2.3 nmol) injected into the rat hippocampus and striatum have been examined with regard to neurochemical, histological and electroencephalographic alterations.
Robert Zaczek +2 more
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ChemInform Abstract: A Concise Route to (‐)‐Kainic Acid.
ChemInform, 2000AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Kunio Ogasawara +2 more
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Kainic acid and the glutamate receptor
Neuroscience Letters, 1978Abstract The excitatory effects of microelectrophoretically administered kainic (KAIN) and glutamic (GLUT) acids have been compared on central neurones of the rat in the presence of antagonists of amino acid-induced excitations. Antagonism by both D-α-amino adipic acid (DAA) and glutamic acid diethyl ester (GDEE) of the effects of glutamic acid but ...
Hall, J., Hicks, T., Mclennan, H.
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Kainic acid induces apoptosis in neurons
Neuroscience, 1996Growing evidence suggests that non-N-methyl-D-aspartate receptor activation may contribute to neuronal death in both acute and chronic neurological diseases. The intracellular processes that mediate this form of neuronal death are poorly understood.
Jean-Christophe Leveque +4 more
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The American Journal of Chinese Medicine, 2016
Interest in the health benefits of flavonoids, particularly their effects on neurodegenerative disease, is increasing. This study evaluated the role of baicalein, a flavonoid compound isolated from the traditional Chinese medicine Scutellaria baicalensis,
Yi Chang +4 more
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Interest in the health benefits of flavonoids, particularly their effects on neurodegenerative disease, is increasing. This study evaluated the role of baicalein, a flavonoid compound isolated from the traditional Chinese medicine Scutellaria baicalensis,
Yi Chang +4 more
semanticscholar +1 more source
An enantioconvergent route to (−)-kainic acid
Tetrahedron Letters, 1997AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Yoshihisa Nakada +2 more
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