Results 251 to 260 of about 5,024,889 (297)

Enantioselective synthesis of (-)-kainic acid

Journal of the American Chemical Society, 1988
AbstractThe title compound (XIV), which is known to possess anthelmintic, insecticidal and neuroexcitatory activity, and its lactone (XV) are prepared via the common intermediate (IX) as shown.
Kunio Ogasawara, Seiichi Takano, Shigeki Satoh, Takumichi Sugihara   +3 more
openaire   +3 more sources

The control of kainic acid-induced status epilepticus

Epilepsy Research, 2010
In the present study the effectiveness of different diazepam-ketamine combinations to control kainic acid-induced status epilepticus in rats was evaluated. We show that electrographic monitoring is mandatory to enable reliable assessment of status epilepticus control as the number of false positives is extremely high when status epilepticus control is ...
Vermoesen, Katia, Clinckers, Ralph, Massie, Ann, Michotte, Yvette, Smolders, Ilse Julia   +4 more
openaire   +8 more sources

A short scalable route to (-)-α-kainic acid using Pt-catalyzed direct allylic amination.

Chemistry, 2015
An increased supply of scarce or inaccessible natural products is essential for the development of more sophisticated pharmaceutical agents and biological tools, and thus the development of atom-economical, step-economical and scalable processes to ...
Ming Zhang, Kenji Watanabe, Masafumi Tsukamoto, Ryozo Shibuya, H. Morimoto, T. Ohshima   +5 more
semanticscholar   +1 more source

Microinjection of kainic acid into the rat hippocampus

European Journal of Pharmacology, 1978
The effects of unilateral injection of kainic acid into the rate hippocampus have been examined in terms of morphologic, neurochemical and behavioral sequelae. Infusion of 10 nmoles if kainate causes a rapid and complete degeneration of neuronal perikarya in the entire hippocampal formation followed by gliosis and atrophy of the region. This unilateral
Joseph T. Coyle, Robert Schwarcz, Robert Zaczek   +2 more
openaire   +3 more sources

Neuroexcitatory amino acids: phosphonic analogue of kainic acid [PDF]

Amino Acids, 1992
The enantioselective synthesis of phosphonic analogue of kainic acid is described.
M. L. Roumestant, M. Tabcheh, L. Pappalardo, Ph. Viallefont   +3 more
openaire   +2 more sources

Kainic acid derivatives with anticonvulsant activity

Neuroscience Letters, 1984
beta-Kainic acid, and the glycine and amino-methylphosphonate derivatives of alpha- and beta-kainic acid, have been injected intracerebroventricularly in DBA/2 mice, that show sound-induced seizure responses. An anticonvulsant effect is observed with marked protection against the tonic and clonic phases of the seizure response.
Brian S. Meldrum, G. Badman, G.P. Hart, A.J. Dixon, James F. Collins, G. De Sarro, Astrid G. Chapman   +6 more
openaire   +3 more sources

Stereocontrolled Total Synthesis of (−)-Kainic Acid

Organic Letters, 2007
[reaction: see text] A stereocontrolled total synthesis of (-)-kainic acid is described. A fully functionalized trisubstituted pyrrolidine ring was constructed by ring-closing metathesis of an acrylate derivative followed by an intramolecular Michael addition of the resultant alpha,beta-unsaturated lactone with high diastereoselectivity.
Hidetoshi Tokuyama, Hiroshi Sakaguchi, Tohru Fukuyama   +2 more
openaire   +2 more sources

Distribution and persistence of kainic acid in brain

Life Sciences, 1979
The distribution of 3H-kainic acid in rat brain was studied as a function of time after injections of 5 nmoles into the neostriatum, substantia nigra or cerebellum. More than half of the injected material had disappeared from the injection site and the brain by 1/2 hour post injection.
Edith G. McGeer, U. Scherer-Singler
openaire   +3 more sources

Ethanol, baclofen, and kainic acid neurotoxicity

Experimental Neurology, 1980
Abstract The neurotoxicity induced by intrastriatal injections of kainic acid was greater in rats drinking approximately 4 ml ethanol per day for 16 days before injection than in controls. Intraperitoneal injection of 5 mg/kg baclofen (parachlorophenyl GABA), 30 min before the kainic acid injections had a slight protective action.
Edith G. McGeer, Alexander Jakubovic, Edith A. Singh   +2 more
openaire   +3 more sources

Action of kainic acid on a glutamatergic synapse

Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1975
Abstract 1. The effect of kainic acid on the locust excitatory nerve-muscle junction was investigated. 2. Kainic acid increased the amplitude of the excitatory postsynaptic potential (EPSP) at a threshold concentration of 5 × 10−5 M. 3. Kainic acid at 10−5 M potentiated the glutamate potential and increased the miniature EPSP frequency without ...
A. Daoud, P.N.R. Usherwood
openaire   +3 more sources