Results 261 to 270 of about 5,024,889 (297)

Effects of rutin on oxidative stress in mice with kainic acid-induced seizure.

Journal of Integrative Medicine, 2013
OBJECTIVE Flavonoids are present in foods such as fruits and vegetables. Several studies have demonstrated a relationship between the consumption of flavonoid-rich foods and prevention of human disease, including neurodegenerative disorders.
Marjan Nassiri-Asl, T. Naserpour Farivar, E. Abbasi, H. Sadeghnia, Mehdi Sheikhi, Mina Lotfizadeh, Parisa Bazahang   +6 more
semanticscholar   +1 more source

Neuronal mapping with kainic acid

Trends in Neurosciences, 1978
Abstract Kainic acid, found naturally-occurring in sea-weed, is a substance which is structurally-related to the putative neurotransmitter, glutamate. Kainic acid has now entered the neuroscientists armoury of equipment as a potent and selective neurotoxin which will cause the fast degeneration of neurones with cell bodies in the area of injection ...
openaire   +2 more sources

Total synthesis of (-)-α-kainic acid via chirality transfer through Ireland-Claisen rearrangement.

Journal of Organic Chemistry, 2013
The total synthesis of (-)-α-Kainic acid is accomplished using a linear strategy involving Noyori asymmetric reduction and chirality transfer through Ireland-Claisen rearrangement as key steps.
Naredla Kesava Reddy, S. Chandrasekhar
semanticscholar   +1 more source

Kainic acid: Neurophysiological and neurotoxic actions

Life Sciences, 1979
Abstract Kainic acid, an anthelmintic drug structurally related to glutamate, has excitatory electrophysiological actions on neurons in the vertebrate CNS and at the invertebrate neuromuscular junction. Recently, it has been shown to destroy neuronal cell bodies and dendrites in several regions of the vertebrate CNS, while sparing afferent fibers and
openaire   +3 more sources

A total synthesis of (±)--kainic acid

Tetrahedron Letters, 1986
AbstractThe ring‐opened ylide (II) of the aziridine carboxylic acid ester (I) reacts with the αβ‐unsaturated oxo‐compound (III) to give the pyrrolidine carboxylic acid ester (IV) and its diastereomer (V).
David A. Kell, Philip DeShong
openaire   +3 more sources

Diastereoselective rhodium-catalyzed ene-cycloisomerization reactions of alkenylidenecyclopropanes: total synthesis of (-)-α-kainic acid.

Journal of the American Chemical Society, 2012
The rhodium-catalyzed ene-cycloisomerization of alkenylidenecyclopropanes provides an atom-economical approach to five-membered carbo- and heterocycles that contain two new stereogenic centers.
P. Evans, P. Inglesby
semanticscholar   +1 more source

Iontophoresis of kainic acid [PDF]

Neurochemical Research, 1981
J. A. McCaughran, Edith G. McGeer
openaire   +2 more sources

ChemInform Abstract: A New Enantiocontrolled Route to (‐)‐Kainic Acid.

ChemInform, 1997
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Kunio Ogasawara, Mitsuhiro Kawamura
openaire   +3 more sources

The activation of glutamate receptors by kainic acid and domoic acid

Natural Toxins, 1998
The neurotoxins kainic acid and domoic acid are potent agonists at the kainate and alphaamino-5-methyl-3-hydroxyisoxazolone-4-propionate (AMPA) subclasses of ionotropic glutamate receptors. Although it is well established that AMPA receptors mediate fast excitatory synaptic transmission at most excitatory synapses in the central nervous system, the ...
David R. Hampson, Jerrie Lynn Manalo
openaire   +3 more sources

Fresh green tea and gallic acid ameliorate oxidative stress in kainic acid-induced status epilepticus.

Journal of Agricultural and Food Chemistry, 2012
Green tea is one of the most-consumed beverages due to its taste and antioxidative polyphenols. However, the protective effects of green tea and its constituent, gallic acid (GA), against kainic acid (KA)-induced seizure have not been studied.
Hsiao-Ling Huang, Chih-Cheng Lin, K. Jeng, Pei-Wun Yao, L. Chuang, Su-Ling Kuo, C. Hou   +6 more
semanticscholar   +1 more source