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Kainic acid and 1′‐hydroxykainic acid from palmariales
Natural Toxins, 1994AbstractThe distribution of kainic acid among various red algae was investigated. Analysis of free amino acids from different populations of Palmaria palmata showed that some were unable to accumulate kainic acid to detectable concentrations, whereas in two dwarf mutants it was a major component of the free amino acid composition.
Maurice V. Laycock +4 more
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Kainic acid versus response in the cat
Behavioural Brain Research, 1996The emotional-defensive response (EDR) and accompanied neurotoxic and electroencephalographic (EEG) effects induced by injection of kainic acid (KA, 0.1; 0.2 microgram) into the midbrain periaqueductal grey region (PAG) and antero-medial hypothalamus (AMH) in the cat were examined and compared with EDR and accompanied neurotoxic and EEG effects induced
J Konopacki, B Eckersdorf, H Golebiewski
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Some approaches to the synthesis of kainic acid
Journal of the Chemical Society, Perkin Transactions 1, 1984A strategy for the synthesis of the anthelmintic kainic acid is described, involving an investigation of the [3 + 2] cycloaddition reactions of some azomethine ylides obtained from the thermal ring opening of aziridines and 4,5-dihydro-1,2,3-triazoles, with cyclopentenone.
Calum H. Strachan +3 more
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Organic Letters, 2012
An enantioselective synthesis of (-)-(α)-kainic acid in 15 steps with an overall yield of 24% is reported. The pyrrolidine kainoid precursor with the required C2/C3 trans stereochemistry was prepared with complete diastereoselectivity via an ...
Zhibin Luo, Bing Zhou, Yuanchao Li
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An enantioselective synthesis of (-)-(α)-kainic acid in 15 steps with an overall yield of 24% is reported. The pyrrolidine kainoid precursor with the required C2/C3 trans stereochemistry was prepared with complete diastereoselectivity via an ...
Zhibin Luo, Bing Zhou, Yuanchao Li
semanticscholar +1 more source
Synaptic localization of kainic acid binding sites
Nature, 1981The heterocyclic compound kainic acid (KA) is a potent excitant when applied to mammalian neurones. Lesions caused by injections of KA into the rat striatum and hippocampus cause similar patterns of damage to those seen in Huntington's chorea and status epilepticus, respectively.
Alan C. Foster +3 more
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Structure of Kainic Acid and its Isomer, Allokainic Acid
Nature, 1958IN 1953, Murakami, Takemoto and their collaborators1 isolated the most active component of Digenea simplex Agardh which has been well known as an anthelmintic (vermifuge) for more than a thousand years. They named it kainic acid after ‘Kaininso’, the Japanese name of the mother alga. Kainic acid, C10H15O4N, has an intense anthelmintic effect, about ten
Y. Tomiie, I. Nitta, H. Watase
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Total Syntheses of (–)‐α‐Kainic Acid
, 2012Kainoid amino acids are a unique group of non-proteinogenic pyrrolidinedicarboxylic acids. The parent member, (–)-α-kainic acid (originally known as digenic acid), has attracted considerable interest, largely because of its neuroexcitatory properties, as
Christos I Stathakis +2 more
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Limbic Seizures Induced by Systemically Applied Kainic Acid: How Much Kainic Acid Reaches the Brain?
1986Systemic or intracerebral injection of the neurotoxin kainic acid (KA) in rats induces a limbic seizure and brain damage syndrome, which has been proposed as an experimental animal model for human temporal lobe epilepsy (Nadler, 1981; Ben-Ari, 1985). The electrographic, neurochemical, metabolic and histopathological consequences involve preferentially ...
M.L. Berger +3 more
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Synfacts, 2006