Results 211 to 220 of about 156,286 (266)

Long-Term Outcomes of Simultaneous Integrated Boost in Node-Positive Cervical Cancer: A Single-Institution Retrospective Study. [PDF]

Cureus
Bonala SR, Subramanian BV, Venati C, Raja SA.   +3 more
europepmc   +1 more source

Halofuginone is a Molecular Glue Degrader of Integrin β4

Advanced Science, EarlyView.
Integrin β4 overexpression is linked to aggressive tumors and poor prognosis, but targeted therapies are lacking. We identified halofuginone (HF) as a molecular glue degrader that promotes integrin β4 degradation via the CRL4BWDR18 E3 ligase. HF suppresses tumor progression in vitro and in vivo, offering a new strategy for targeting oncogenic ...
Wei Gong, Di Yang, Junrui Tian, Yufei Chai, Tiantian Yu, Qingnan Wu, Yan Wang, Weimin Zhang, Qimin Zhan   +8 more
wiley   +1 more source

Sotatercept Versus Selexipag in Severe Pulmonary Arterial Hypertension: An Indirect Comparison of Efficacy Based on an Artificial-Intelligence Method That Reconstructed Patient-Level Data From Three Randomized Trials. [PDF]

Cureus
Messori A, Brunoro R, Paolì MG, Rivano M.   +3 more
europepmc   +1 more source

Estimating Between-Trial Heterogeneity in Meta-Analyses Based on Two-Arm Clinical Trials with Outcomes Reported as Kaplan-Meier Curves

Andrea Messori, Vera Damuzzo, Andrea Ossato, Eugenia Piragine, Sara Veneziano, Vincenzo Calderone   +5 more
openalex   +2 more sources

Disulfide‐Bridged Ru Complex–Mediated Photo‐Disulfidptosis for Colorectal Cancer Therapy

Advanced Science, EarlyView.
In this work, a binuclear ruthenium complex, RuSSRu was developed for efficient colorectal cancer (CRC) treatment. The synergistic interaction between disulfidptosis and lysosomal damage‐induced apoptosis induced by RuSSRu amplified tumor cell death. This innovative approach offers a potent therapeutic strategy for CRC.
Simeng He, Wendong Jin, Jiaojiao Pang, Xiaoting Gong, Shixian Cao, Duo Mao, Yuguo Chen, Kang‐Nan Wang, Bin Liu   +8 more
wiley   +1 more source

Direct Anastomosis Versus Conduit Repair for Right Ventricular Outflow Tract Reconstruction in Common Arterial Trunk: A Meta-Analysis of Reconstructed Time-to-Event Data. [PDF]

Interdiscip Cardiovasc Thorac Surg
Almehandi A, Diniz L, Marrazzo EB, Veiga AL, Alotaibi L, Ali Y, Al-Naseem AO, Al Kindi H, Kerst G, Caldonazo T.   +9 more
europepmc   +1 more source

Kaplan–Meier estimates of cumulative incidence for autism spectrum disorder by cumulative dose exposure level among children born to birthing parents with diagnosed painful conditions.

Emma N. Cleary (21103967), Ayesha C. Sujan (8066429), Martin E. Rickert (8066435), Franziska Fischer (1660498), Tyra Lagerberg (6855221), Zheng Chang (432352), Paul Lichtenstein (47559), Patrick D. Quinn (8066432), Anna Sara Öberg (22258174), Brian M. D’Onofrio (3071223)   +9 more
openalex   +1 more source

GALNT10 Affects O‐Glycosylation of IGFBP7 to Promote Tumor Vascular Remodeling and Metastasis of Ovarian Cancer

Advanced Science, EarlyView.
The glycosyltransferase GALNT10 facilitates ovarian cancer metastasis through the induction of tumor cell EMT and tumor vascular dysfunction. GALNT10 enhanced the extracellular secretion of IGFBP7 through O‐GalNAc glycosylation modification at the T188 site, which subsequently interacts with CD93 on endothelial cells, leading to vascular remodeling ...
Yanan Zhang, Ayala Zuha, Zhangxin Wu, Aiping Luo, Bixia Jin, Qinkun Sun, Yuan Li, Qiyu Liu, Hongyan Guo, Chunliang Shang   +9 more
wiley   +1 more source