Results 101 to 110 of about 730,949 (275)

MORTALIDAD DE LA NIÑEZ MENOR DE CINCO AÑOS EN BOLIVIA: ANÁLISIS DE SUPERVIVENCIA Y SUS FACTORES DE RIESGO ASOCIADOS

Investigación & Desarrollo, 2019
La mortalidad en la niñez menor de cinco años (5q0) es un factor que se asocia con el bienestar de una población y un indicador de desarrollo en salud y el estado socioeconómico de un país. Según el Informe sobre Equidad en Salud del año 2015, los países
Pamela Córdova Olivera, Soraya Román Eyzaguirre, Zarela Soria Galvarro Ferrufino   +2 more
doaj  

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

An evaluation on diagnosis and management patterns of patients with oral squamous cell carcinoma referred to the Cancer Institute of Tehran Medical University during 2010-2021

Journal of Craniomaxillofacial Research, 2023
Background: Squamous cell carcinoma (SCC) is the most common malignancy of the oral cavity with multiple complications associated with the disease and its treatments and a high mortality rate.
Ata Garajei, Sarah Pishva, Azadeh Emami
doaj  

Efficacy of hepatic transplantation in patients with primary sclerosing cholangitis [PDF]

, 1993
Controlled trials to assess the therapeutic benefit of orthotopic hepatic transplantation (OHTx) for primary sclerosing cholangitis (PSC) cannot be justified in view of improvement of patient survival after this operation since 1981.
Abu-Elmagd, KM, Demetris, AJ, Dickson, ER, Fung, JJ, Krom, RAF, Langworthy, AL, Malinchoc, M, Murtaugh, PA, Starzl, TE, Van Thiel, DH   +9 more
core  

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

UNEMPLOYMENT IN SLOVENIA: IMPACT OF GENDER DISPARITIES DURING UNEMPLOYMENT SPELLS [PDF]

Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2010
Human capital is one of the most important driving forces for economic competitiveness, development and growth. One half of a nation’s skills, knowledge, and productivity is represented by women.
Darja BORŠIČ, Alenka KAVKLER, Polona PAŠIČ   +2 more
doaj  

Tratamento de dados censurados em estudos ambientais

Química Nova, 2014
Due to the inherent limitations of the analytical methods of measurement, environmental exposure data often present observations described as below a certain detection limit, also called left-censored data. Censored data directly interferes in almost all
Cristiano Christofaro, Mônica M. D. Leão   +1 more
doaj   +1 more source

Nearest Neighbor and Kernel Survival Analysis: Nonasymptotic Error Bounds and Strong Consistency Rates

, 2019
We establish the first nonasymptotic error bounds for Kaplan-Meier-based nearest neighbor and kernel survival probability estimators where feature vectors reside in metric spaces.
Chen, George H.
core