Results 61 to 70 of about 730,949 (275)
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Delta method in large deviations and moderate deviations for estimators [PDF]
, 2011 The delta method is a popular and elementary tool for deriving limiting distributions of transformed statistics, while applications of asymptotic distributions do not allow one to obtain desirable accuracy of approximation for tail probabilities.
Gao, Fuqing, Zhao, Xingqiu
core +2 more sources
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Mean Survival Time from Right Censored Data [PDF]
, 2009 A nonparametric estimate of the mean survival time can be obtained as the area under the Kaplan-Meier estimate of the survival curve. A common modification is to change the largest observation to a death time if it is censored.
Hess, Kenneth R, Zhong, Ming
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Survival and dispersal of a defined cohort of Irish cattle
Irish Veterinary Journal, 2009 An understanding of livestock movement is critical to effective disease prevention, control and prediction. However, livestock movement in Ireland has not yet been quantified. This study has sought to define the survival and dispersal of a defined cohort
Ashe S +5 more
doaj +1 more source
Semiparametric linear regression with censored data and stochastic regressors [PDF]
, 1994 We propose three new estimation procedures in the linear regression model with randomly-right censored data when the distribution function of the error term is unspecified, regressors are stochastic and the distribution function of the censoring variable
Mora, Juan
core +1 more source
GLUT1 expression patterns in different Hodgkin lymphoma subtypes and progressively transformed germinal centers [PDF]
, 2012 Background: Increased glycolytic activity is a hallmark of cancer, allowing staging and restaging with 18F-fluorodeoxyglucose-positron-emission-tomography (PET).
Agostinelli, Claudio +9 more
core +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Estimating the Survival Distribution for Right-Censored Data with Delayed Ascertainment [PDF]
, 2012 In many clinical trials, patients are not followed continuously. This means their vital status may not be immediately recorded. In such cases, the results from the Kaplan-Meier estimator or the log rank test, popular methods used for survival analysis ...
Kim, Eun-Jin
core