Results 111 to 120 of about 237,530 (303)

Sick of work or too sick to work? Evidence on health shocks and early retirement from the BHPS [PDF]

open access: yes, 2007
We follow individuals as they retire using discrete-time hazard models applied to a stock sample from 12 waves of the British Household Panel Survey.
Jones, A.M., Rice, N., Roberts, J.
core  

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

The Kaplan Meier Estimate in Survival Analysis [PDF]

open access: yesBiometrics & Biostatistics International Journal, 2017
Kaplan-Meier is a statistical method used in the analysis of time to event data. Time to event means the time from entry into a study until a particular event, for example onset of illness. This method is very useful in survival analysis as it is used by the researchers to determine and/or analyze the patients or participants who lost to follow up or ...
openaire   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

A Combinatoric Approach to the Kaplan-Meier Estimator

open access: yesThe Annals of Statistics, 1985
The paper considers the Kaplan-Meier estimator \(F_ n^{KM}\) from a combinatoric viewpoint. Under the assumption that the estimated distribution F and the censoring distribution G are continuous, the combinatoric results are used to show that \(\int | \theta (z)| dF_ n^{KM}(z)\) has expectation not larger than \(\int | \theta (z)| dF(z)\) for any ...
openaire   +3 more sources

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

An Online Updating Approach for Testing the Proportional Hazards Assumption with Streams of Big Survival Data

open access: yes, 2018
The Cox model, which remains as the first choice in analyzing time-to-event data even for large datasets, relies on the proportional hazards assumption. When the data size exceeds the computer memory, the standard statistics for testing the proportional ...
Schifano, Elizabeth D.   +3 more
core   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

open access: yesFEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo   +7 more
wiley   +1 more source

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

open access: yesAging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha   +4 more
wiley   +1 more source

Efficacy of hepatic transplantation in patients with primary sclerosing cholangitis [PDF]

open access: yes, 1993
Controlled trials to assess the therapeutic benefit of orthotopic hepatic transplantation (OHTx) for primary sclerosing cholangitis (PSC) cannot be justified in view of improvement of patient survival after this operation since 1981.
Abu-Elmagd, KM   +9 more
core  

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