Results 101 to 110 of about 237,530 (303)

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Thromboelastography Parameters as Predictors for Long-Term Survival in Critically Ill Patients

Clinical and Applied Thrombosis/Hemostasis, 2019
Thromboelastography (TEG) is used for monitoring abnormal blood coagulation in critically ill patients. However, the correlation between TEG parameters and long-term survival in these patients is unknown.
Cuizhu Luo MS, Bingjie Zhuang MS, Zhongqing Chen PhD   +2 more
doaj   +1 more source

The Unintended Consequences of Flexicurity : The Health Consequences of Flexible Employment [PDF]

, 2015
Publisher ...
Bender, Keith Allen, Theodossiou, Ioannis   +1 more
core  

Modeling the number of hidden events subject to observation delay

, 2019
This paper considers the problem of predicting the number of events that have occurred in the past, but which are not yet observed due to a delay. Such delayed events are relevant in predicting the future cost of warranties, pricing maintenance contracts,
Antonio, Katrien, Crevecoeur, Jonas, Verbelen, Roel   +2 more
core   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Statistical properties of extragalactic sources in the New Extragalactic WMAP Point Source (NEWPS) catalogue

, 2007
We present results on spectral index distributions, number counts, redshift distribution and other general statistical properties of extragalactic point sources in the NEWPS5 sample L\'opez-Caniego et al. (2007).
Bennett, Bertin, Cantor, Cleary, Condon, Condon, D. Herranz, Danese, De Zotti, De Zotti, Eddington, Ekers, F. Argüeso, G. De Zotti, González-Nuevo, Gregory, Griffith, Griffith, Herranz, Hinshaw, Hogg, J. González-Nuevo, J. L. Sanz, Kaplan, L. Toffolatti, Lucy, López-Caniego, López-Caniego, M. López-Caniego, M. Massardi, Massardi, Mauch, Planck Collaboration, Ricci, Ricci, Sadler, Taylor, Toffolatti, Toffolatti, Waldram, Waldram, Wright, Wright   +42 more
core   +1 more source

Kaplan-Meier survival estimation

, 2007
U radu je dat opis algoritma Kaplan-Meier-ovog metoda preživljavanja na grupi od 42 bolesnika KBC Zemun. Njegova metodologija je zasnovana na izračunavanju verovatnoće preživljavanja ispitanika posle nekog događaja ili izračunavanje verovatnoće da će se neki događaj desiti u različitim trenucima.
Maletić, Radojka, Peruničić-Peković, Gordana   +1 more
openaire   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Multiple imputation for estimation of an occurrence rate in cohorts with attrition and discrete follow-up time points: a simulation study

BMC Medical Research Methodology, 2010
Background In longitudinal cohort studies, subjects may be lost to follow-up at any time during the study. This leads to attrition and thus to a risk of inaccurate and biased estimations.
Soullier Noémie, de La Rochebrochard Elise, Bouyer Jean   +2 more
doaj   +1 more source