Results 81 to 90 of about 237,530 (303)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Determination of the most appropriate method for extrapolating overall survival data from a placebo-controlled clinical trial of lenvatinib for progressive, radioiodine-refractory differentiated thyroid cancer [PDF]

, 2016
Background: Cost-effectiveness models for the treatment of long-term conditions often require information on survival beyond the period of available data.
Briggs, Andrew, Crowe, Lydia, Kapetanakis, Venediktos, Livings, Christopher, Tremblay, Gabriel   +4 more
core   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Application of a simple nonparametric conditional quantile function estimator in unemployment duration analysis [PDF]

We consider an extension of conventional univariate Kaplan-Meier type estimators for the hazard rate and the survivor function to multivariate censored data with a censored random regressor.
Wichert, Laura, Wilke, Ralf A.
core  

Timing and Determinants of Tuberculosis Treatment Interruption in Nairobi County, Kenya [PDF]

, 2017
Tuberculosis (TB) treatment is a key pillar in the management and control of TB. Service delivery within the treatment facilities plays an important role in ensuring treatment adherence by TB patients.
Amukoye, E. (Evans), Jepchumba, V. (Violet), Karanja, S. (Simon), Kipruto, H. (Hillary), Muthami, L. (Lawrence)   +4 more
core   +3 more sources

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Is There a Two-Way Risk between Decreased Testosterone Levels and the Progression and Prognosis of Chronic Kidney Disease? A Cohort Study Based on the National Health and Nutrition Examination Survey Database

The World Journal of Men's Health
Purpose: The causal relationship between the incidence and prognosis of chronic kidney disease (CKD) and serum testosterone levels in patients is not yet fully understood.
Jiashan Pan, Zhenming Zheng, Xike Mao, Dekai Hu, Wenbo Wang, Guiyi Liao, Zongyao Hao   +6 more
doaj   +1 more source

Miners’ return to work following injuries in coal mines

Medycyna Pracy, 2016
Background: The occupational injuries in mines are common and result in severe socio-economical consequences. Earlier studies have revealed the role of multiple factors such as demographic factors, behavioral factors, health-related factors, working ...
Ashis Bhattacherjee, Bijay Mihir Kunar
doaj   +1 more source

Prognostic Significance of Lactate Dehydrogenase in Patients Undergoing Surgical Resection for Laryngeal Squamous Cell Carcinoma

Cancer Control, 2020
The aim is to estimate the prognostic value of lactate dehydrogenase (LDH) in patients undergoing surgical resection for laryngeal squamous cell carcinoma (LSCC). A total of 640 resected LSCC patients were included.
Erliang Guo MD, Lunhua Guo MD, Changming An MD, Cong Zhang MD, Kaibin Song MD, Guohui Wang MD, Chunbin Duan MD, Xiwei Zhang MD, Xianguang Yang MD, Zhennan Yuan MD, Junnan Guo MD, Ji Sun MD, Hongxue Meng MD, Rui Chang MD, Xiaomei Li MD, Cheng Xiu MD, Xionghui Mao MD, Susheng Miao MD   +17 more
doaj   +1 more source

Cost-effectiveness analysis in R using a multi-state modelling survival analysis framework: a tutorial [PDF]

, 2016
This tutorial provides a step-by-step guide to performing cost-effectiveness analysis using a multi-state modelling approach. Alongside the tutorial we provide easy-to-use functions in the statistics package R.
Briggs, Andrew H., Lewsey, James D., Mackay, Daniel F., Williams, Claire   +3 more
core   +2 more sources