Mitochondrial protein, TBRG4, modulates KSHV and EBV reactivation from latency
Kaposi’s sarcoma-associated herpesvirus (KSHV) and Epstein-Barr (EBV) are gammaherpesviruses associated with multiple human malignancies. KSHV is the etiological agent of Kaposi’s Sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman’s ...
Huirong Zhang +5 more
doaj
As obligate intracellular pathogens, viruses depend on the host cell machinery to complete their life cycle. Kaposi’s sarcoma-associated herpesvirus (KSHV) is an oncogenic virus causally linked to the development of Kaposi’s sarcoma and several other ...
Wei Zhang, Shou-Jiang Gao
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Unicentric mixed variant castleman disease associated with intrabronchial plasmacytoma. [PDF]
Castleman disease (CD), described as a heterogeneous lymphoproliferative disorder, can be divided into different subtypes according to clinical appearance (unicentric and multicentric form) and histopathological features (hyaline vascular, plasma cell ...
A Carbone +42 more
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SUMO Modification Stabilizes Enterovirus 71 Polymerase 3D To Facilitate Viral Replication. [PDF]
Accumulating evidence suggests that viruses hijack cellular proteins to circumvent the host immune system. Ubiquitination and SUMOylation are extensively studied posttranslational modifications (PTMs) that play critical roles in diverse biological ...
Gong, P +9 more
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Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8).
As epidemiologic evidence accumulates, it is becoming increasingly clear that Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) (or human herpesvirus 8 [HHV-8]) is the likely infectious cause of KS and related neoplastic disorders. Immunosuppression is an important cofactor in KS pathogenesis, as shown by the occurrence of KS in post-transplant ...
openaire +2 more sources
Bilateral inhibition of HAUSP deubiquitinase by a viral interferon regulatory factor protein [PDF]
Herpesvirus-associated ubiquitin specific protease (HAUSP) regulates the stability of p53 and MDM2, implicating HAUSP as a therapeutic target for tuning p53-mediated anti-tumor activity.
A Dong +55 more
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De Novo Protein Synthesis Is Required for Lytic Cycle Reactivation of Epstein-Barr Virus, but Not Kaposi's Sarcoma-Associated Herpesvirus, in Response to Histone Deacetylase Inhibitors and Protein Kinase C Agonists [PDF]
Jianjiang Ye +3 more
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Co-infections and Pathogenesis of KSHV-Associated Malignancies
Kaposi’s sarcoma-associated herpesvirus (KSHV), also known as human herpes virus 8 (HHV-8) is one of the several carcinogenic viruses that infect humans.
Suhani eThakker, Subhash C Verma
doaj +1 more source
Studies on early cellular responses during Epstein-Barr virus infection [PDF]
The human gamma-herpesvirus Epstein-Barr virus (EBV) has been implicated in the pathogenesis of a broad spectrum of lymphoid and epithelial cell malignancies.
Chen, Xinsong
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Supplementary Table 1 from Novel Cellular Genes Essential for Transformation of Endothelial Cells by Kaposi's Sarcoma–Associated Herpesvirus [PDF]
Camilo Raggo +6 more
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