Results 101 to 110 of about 5,941 (171)

CRISPR-Cas9 Screening of Kaposi’s Sarcoma-Associated Herpesvirus-Transformed Cells Identifies XPO1 as a Vulnerable Target of Cancer Cells

mBio, 2019
The abnormal proliferation of cancer cells is driven by deregulated oncogenes or tumor suppressors, among which the cancer-vulnerable genes are attractive therapeutic targets.
Marion Gruffaz, Hongfeng Yuan, Wen Meng, Hui Liu, Sangsu Bae, Jin-Soo Kim, Chun Lu, Yufei Huang, Shou-Jiang Gao   +8 more
doaj   +1 more source

Gastric Kaposi Sarcoma With Distinct “Lobster‐Like” Endoscopic Lesions in a Human Immunodeficiency Virus‐Positive Patient

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Kaposi Sarcoma (KS) is a rare vascular tumor linked to Human Herpesvirus‐8 (HHV‐8) infection, most often affecting immunocompromised patients with Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS). Gastrointestinal KS (GI‐KS) is frequently underdiagnosed, particularly in resource‐limited settings, and may present with ...
Seyed Ali Safizadeh Shabestari, Aidin Farahvash, Mohammad Jafar Farahvash   +2 more
wiley   +1 more source

Oncolytic Therapy: Delivery System and New Therapeutic Strategies for Cancer

MedComm, Volume 7, Issue 4, April 2026.
This review summarizes recent advances in nanoparticle‐ and cell‐mediated OVs delivery strategies that improve biodistribution and tumor targeting while limiting immune clearance. It also examines combination approaches that enhance therapeutic efficacy through tumor microenvironment modulation or immune activation, thereby overcoming immunosuppression
Sikan Jin, Yi Zhang, Ziling Zhou, Yaqi Zhang, Ting Yu, Rui Xu, Lin Xu, Jidong Zhang, Longze Zhang, Shan Yang, Xianyao Wang   +10 more
wiley   +1 more source

Celecoxib Inhibits the Lytic Activation of Kaposi’s Sarcoma-Associated Herpesvirus through Down-Regulation of RTA Expression by Inhibiting the Activation of p38 MAPK

Viruses, 2015
Kaposi’s sarcoma associated herpesvirus (KSHV) is the etiologic agent of Kaposi’s sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman’s disease (MCD).
Jungang Chen, Liangyu Jiang, Ke Lan, Xulin Chen   +3 more
doaj   +1 more source

Bilateral inhibition of HAUSP deubiquitinase by a viral interferon regulatory factor protein [PDF]

, 2011
Herpesvirus-associated ubiquitin specific protease (HAUSP) regulates the stability of p53 and MDM2, implicating HAUSP as a therapeutic target for tuning p53-mediated anti-tumor activity.
A Dong, A Vagin, A Ventura, AM De Marzo, AT Agoston, C Bronner, CE Petre, CJ Brown, CK Min, CL Brooks, CP Martins, D Komander, E Meulmeester, Eunha Hwang, F Bunz, F Sarkari, GN Murshudov, H Katano, HR Lee, HR Lee, HR Lee, Hye-Ra Lee, Jae U Jung, JM Cummins, JM Gump, JP Kruse, JS Lee, JS Wadia, JT Lee, Juergen Haas, Jungwon Hwang, K Bhatia, Koushik Guchhait, M Hu, M Wade, MN Holowaty, Myung Hee Kim, N Sivachandran, P Emsley, P Uetz, R Zhang, RA Laskowski, RD Everett, S Lain, SA Keller, Stacy Lee, Tae-Kwang Oh, V Saridakis, W Wu, Won-Chan Choi, Y Sheng, Y Yang, Young Ho Jeon, Z Du, Z Otwinowski, Zsolt Toth   +55 more
core   +1 more source

Immune non‐response despite effective antiretroviral therapy in people living with HIV: A review of potential mechanisms, biomarkers and therapeutic approaches

HIV Medicine, Volume 27, Issue 4, Page 498-512, April 2026.
Abstract Introduction A proportion of people living with HIV (PLWH) fail to restore their CD4 count or their CD4/CD8 ratio despite effective antiretroviral therapy (ART). PLWH with immune non‐response (INR) are at a higher risk of both AIDS and non‐AIDS events. The underlying mechanisms of INR remain unclear.
Charlotte Silvestre, Antoine Gross, Alain Makinson   +2 more
wiley   +1 more source

Transfusion-transmitted infections [PDF]

, 2007
Although the risk of transfusion-transmitted infections today is lower than ever, the supply of safe blood products remains subject to contamination with known and yet to be identified human pathogens.
Florian Bihl, Damiano Castelli, Francesco Marincola, Roger Y Dodd, Christian Brander, M Pittman, MG McEntegart, EL Snyder, G Andreu, JC Faber, JC Faber, SJ Wagner, CD Hillyer, CDC, ME Brecher, MA Blajchman, CT Fang, MT Niu, CF Hogman, M Goldman, CP McDonald, CK Lee, SJ Wagner, D de Korte, M Chassaigne, ME Brecher, ME Brecher, CP McDonald, GA Ortolano, SL Stramer, CG Schuttler, JP Allain, S Kleinman, RY Dodd, MP Busch, S Laperche, J Coste, GM Busch, R Offergeld, C Niederhauser, C Velati, K Soldan, J Pillonel, M Alvarez do Barrio, E Delwart, H Yugi, E Brojer, B Weber, A Yoshikawa, K Soldan, R Biswas, A Sanchez-Quijano, I Cacciola, PF Coleman, B Weber, E Tabor, CJ Liu, D Prati, JM Jongerius, S Levicnik-Stezinar, LH Gould, LN Pealer, CDC, MP Busch, SL Stramer, LR Petersen, B Custer, CT Korves, MH Koppelman, A Manns, EL Murphy, EL Murphy, DF Roucoux, FA Proietti, SL Stramer, EC Vamvakas, MA Blajchman, MR Visconti, MA Blajchman, DM Knowles, W Hladik, SC Dollard, N Regamey, RY Dodd, MA Blajchman, CG Wu, UF Koenigbauer, A Plentz, J Blumel, MH Koppelman, P Gowland, AH Diwan, E Boxall, K Matsubayashi, T Nishizawa, Y Tanaka, WE Hitzler, S Zhong, MJ Jeon, J Akiba, D Kumar, AD Kitchen, G Kinde, M Frey-Wettstein, E Purdy, F Alkassab, HW Reesink, M Mungai, CR Seed, American Association of Blood Banks, A Kitchen, PL Chiodini, O Silvie, DA Leiby, DA Leiby, GA Schmunis, LJ Cardo, A Saito-Ito, DA Leiby, N Hunter, CA Llewelyn, AH Peden, PE Hewitt, AC Ghani, JA Aznar, P Hellstern, JP Pelletier, A Pineda, S Murphy, F Knutson, WC Van Voorhis, J McCullough, RJ Benjamin, B Zavizion, B Zavizion, T Mather, A Ohagen, F Corbin 3rd, RP Goodrich, RP Goodrich, LD Fast, LJ Cardo, PH Ruane, CP Engelfriet, J Debeir   +144 more
core   +1 more source

Penile Kaposi sarcoma: A case of complete resolution with highly active antiretroviral therapy alone [PDF]

, 2011
Kaposi sarcoma remains an important cause of morbidity in HIV-infected patients. Regardless of the recent pharmacological progress, treatment of this malignancy is still disappointing.
Alves, R., Caetano, M., Pinto-Almeida, T., Rosmaninho, A., Sanches, M., Selores, M., Torres, T.   +6 more
core   +1 more source

Trends in Kaposi's sarcoma-associated Herpesvirus antibodies prior to the development of HIV-associated Kaposi's sarcoma: a nested case-control study. [PDF]

, 2014
HIV-associated Kaposi's sarcoma (KS) is a public health challenge in sub-Saharan Africa since both the causative agent, Kaposi's sarcoma associated-herpesvirus (KSHV), and the major risk factor, HIV, are prevalent. In a nested case-control study within a
Elliott, Alison M, Johnston, W Thomas, Mayanja, Billy N, Miley, Wendell, Nalwoga, Angela, Newton, Robert, Wakeham, Katie, Webb, Emily L, Whitby, Denise   +8 more
core   +1 more source

Mitochondrial protein, TBRG4, modulates KSHV and EBV reactivation from latency

PLoS Pathogens, 2022
Kaposi’s sarcoma-associated herpesvirus (KSHV) and Epstein-Barr (EBV) are gammaherpesviruses associated with multiple human malignancies. KSHV is the etiological agent of Kaposi’s Sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman’s ...
Huirong Zhang, Jason P. Wong, Guoxin Ni, Patricio Cano, Dirk P. Dittmer, Blossom Damania   +5 more
doaj