Results 1 to 10 of about 226 (66)
A homozygous KASH5 frameshift mutation causes diminished ovarian reserve, recurrent miscarriage, and non-obstructive azoospermia in humans [PDF]
Frontiers in Endocrinology, 2023 The meiosis-specific LINC complex, composed of the KASH5 and SUN1 proteins, tethers the moving chromosomes to the nuclear envelope to facilitate homolog pairing and is essential for gametogenesis.
Xiaoning Hou +55 more
doaj +4 more sources
The KASH5 protein involved in meiotic chromosomal movements is a novel dynein activating adaptor [PDF]
eLife, 2022 Dynein harnesses ATP hydrolysis to move cargo on microtubules in multiple biological contexts. Dynein meets a unique challenge in meiosis by moving chromosomes tethered to the nuclear envelope to facilitate homolog pairing essential for gametogenesis ...
Ritvija Agrawal +7 more
doaj +4 more sources
A human infertility-associated KASH5 variant promotes mitochondrial localization [PDF]
Scientific Reports, 2021 KASH5 is the most recently identified member of the KASH domain family of tail anchored, outer nuclear membrane (ONM) and endoplasmic reticulum (ER) proteins.
Sana A. Bentebbal +5 more
doaj +6 more sources
Molecular insights into LINC complex architecture through the crystal structure of a luminal trimeric coiled-coil domain of SUN1 [PDF]
Frontiers in Cell and Developmental Biology, 2023 The LINC complex, consisting of interacting SUN and KASH proteins, mechanically couples nuclear contents to the cytoskeleton. In meiosis, the LINC complex transmits microtubule-generated forces to chromosome ends, driving the rapid chromosome movements ...
Manickam Gurusaran +3 more
doaj +2 more sources
A molecular mechanism for LINC complex branching by structurally diverse SUN-KASH 6:6 assemblies [PDF]
eLife, 2021 The Linker of Nucleoskeleton and Cytoskeleton (LINC) complex mechanically couples cytoskeletal and nuclear components across the nuclear envelope to fulfil a myriad of cellular functions, including nuclear shape and positioning, hearing, and meiotic ...
Manickam Gurusaran, Owen Richard Davies
doaj +2 more sources
Defects in meiosis I contribute to the genesis of androgenetic hydatidiform moles [PDF]
The Journal of Clinical InvestigationTo identify novel genes responsible for recurrent hydatidiform moles (HMs), we performed exome sequencing on 75 unrelated patients who were negative for mutations in the known genes.
Maryam Rezaei +31 more
doaj +2 more sources
Cancer Communications, Volume 42, Issue 5, Page 374-400, May 2022., 2022 Abstract Dynamic and heterogeneous interaction between tumor cells and the surrounding microenvironment fuels the occurrence, progression, invasion, and metastasis of solid tumors. In this process, the tumor microenvironment (TME) fractures cellular and matrix architecture normality through biochemical and mechanical means, abetting tumorigenesis and ...
Hanying Zhou +14 more
wiley +1 more source
BioMed Research International, Volume 2022, Issue 1, 2022., 2022 Meiotic chromosomes endure rapid prophase movements that ease the formation of interhomologue recombination intermediates that drive synapsis, crossing over, and segregation process. To generate these fast moves, the meiotic telomere complex (MTC) enables telomere‐inner nuclear membrane attachment during meiotic prophase I and transfers cytoskeletal ...
Houda Harmak +6 more
wiley +1 more source
Mechanism and Regulation of Rapid Telomere Prophase Movements in Mouse Meiotic Chromosomes
Cell Reports, 2015 Telomere-led rapid prophase movements (RPMs) in meiotic prophase have been observed in diverse eukaryote species. A shared feature of RPMs is that the force that drives the chromosomal movements is transmitted from the cytoskeleton, through the nuclear ...
Chih-Ying Lee +7 more
doaj +1 more source
PLoS Genetics, 2014 LINC complexes are evolutionarily conserved nuclear envelope bridges, composed of SUN (Sad-1/UNC-84) and KASH (Klarsicht/ANC-1/Syne/homology) domain proteins.
Jana Link +7 more
doaj +1 more source