Results 11 to 20 of about 226 (66)
The meiotic LINC complex component KASH5 is an activating adaptor for cytoplasmic dynein. [PDF]
J Cell Biol, 2023 Cytoplasmic dynein-driven movement of chromosomes during prophase I of mammalian meiosis is essential for synapsis and genetic exchange. Dynein connects to chromosome telomeres via KASH5 and SUN1 or SUN2, which together span the nuclear envelope.
Garner KEL +10 more
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Molecular Human Reproduction, 2022 Abstract KASH5 is an essential component of the LINC (linker of the nucleoskeleton and cytoskeleton) complex that regulates chromosome movements and nuclear envelope (NE) remodeling in mouse spermatocytes during meiosis prophase I, but its expression and function in human cells, as well as its association with male infertility are ...
Chao Yang +14 more
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KASH5 helps meiotic chromosomes LINC up [PDF]
Journal of Cell Biology, 2013 ![Figure][1] Super-resolution microscopy shows rings of KASH5 (green) at the tips of homologous chromosome pairs stained for the axial element protein SCP3 (red). Horn et al.
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Diverse roles for CDK‐associated activity during spermatogenesis
FEBS Letters, Volume 593, Issue 20, Page 2925-2949, October 2019., 2019 The primary function of cyclin‐dependent kinases (CDKs) in complex with their activating cyclin partners is to promote mitotic division in somatic cells. This canonical cell cycle‐associated activity is also crucial for fertility as it allows the proliferation and differentiation of stem cells within the reproductive organs to generate meiotically ...
Nathan Palmer +2 more
wiley +1 more source
How exome sequencing improves the diagnostics and management of men with non‐syndromic infertility
Andrology, Volume 13, Issue 5, Page 1011-1024, July 2025.Abstract Male infertility affects approximately 17% of all men and represents a complex disorder in which not only semen parameters such as sperm motility, morphology, and number of sperm are highly variable, but also testicular phenotypes range from normal spermatogenesis to complete absence of germ cells.
Birgit Stallmeyer +2 more
wiley +1 more source
Advanced Science, Volume 12, Issue 3, January 20, 2025.METTL16 predominantly controls the expression of critical meiotic genes essential for DSB formation and recombination in early meiotic spermatocytes and is involved in the expansion of DNA damage response (DDR) factors and epigenetic modifications in the XY body for the establishment and maintenance of meiotic sex chromosome inactivation (MSCI) in ...
Lisha Yin +16 more
wiley +1 more source
Force transmission and SUN-KASH higher-order assembly in the LINC complex models. [PDF]
Biophys J, 2023 Yerima G +4 more
europepmc +1 more source
Building and breaking mechanical bridges between the nucleus and cytoskeleton: Regulation of LINC complex assembly and disassembly. [PDF]
Curr Opin Cell Biol, 2023 McGillivary RM, Starr DA, Luxton GWG.
europepmc +1 more source