Results 181 to 190 of about 4,475 (201)

A transient blood IL-17 increase triggers neuroinflammation in cerebellum and motor incoordination in hyperammonemic rats. [PDF]

J Neuroinflammation
Arenas YM, Montoliu C, Llansola M, Felipo V.   +3 more
europepmc   +1 more source

Cl^--dependent amplification of excitatory synaptic potentials at distal dendrites revealed by voltage imaging. [PDF]

Sci Adv
Higashi R, Morita M, Kawaguchi SY.
europepmc   +1 more source

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Neuronal Restrictive Silencing Element Is Found in the KCC2 Gene: Molecular Basis for KCC2-Specific Expression in Neurons

Journal of Neurophysiology, 2001
KCC2 is one of four known isoforms of the K-Cl cotransporter with an expression pattern restricted to neurons. It mediates efflux of Cl− across neuronal membranes and plays an important role in GABAergic and glycinergic neurotransmission. To understand the molecular basis for neuronal specificity of KCC2 expression, we isolated and sequenced portions ...
Michael F. Karadsheh, Eric Delpire
openaire   +2 more sources

KCC2, epileptiform synchronization, and epileptic disorders

Progress in Neurobiology, 2018
The K+-Cl- co-transporter KCC2 is a neuron-specific, Cl- extruder that uses K+ gradient for maintaining low intracellular [Cl-]. It is indeed well established that sustaining an outwardly-directed electrochemical Cl- gradient across the neuronal membrane is fundamental for a proper function of postsynaptic GABAA receptor signaling.
Patricia N. Awad, Massimo Avoli, Massimo Avoli, Shabnam Hamidi, Graziella Di Cristo   +4 more
openaire   +3 more sources

Towards a KCC2 blocker pharmacophore model

Bioorganic & Medicinal Chemistry Letters, 2012
A multi-disciplinary approach was used to identify the first pharmacophore model for KCC2 blockers: several physico-chemical studies such as XRD and NMR were combined to molecular modelling techniques, SAR analysis and synthesis of constrained analogues in order to determine a minimal conformational space regrouping few potential bioactive ...
Benoit Mathieu, Ledecq Marie, Kashinath Dhurke, Ananda Kumar Kanduluru, Florence Lebon, Anne Frycia, Cecile Pegurier, Sébastien Lengelé, Laurent Provins, Nathalie Bosman, Christian Wolff, Alain Wagner, Stéphane Meunier   +12 more
openaire   +3 more sources

Distribution and Cellular Localization of KCC2 in the Ferret Neocortex

Developmental Neuroscience, 2018
KCC2 (a brain-specific potassium-chloride cotransporter) affects development of the cerebral cortex, including aspects of neuronal migration and cellular maturation and differentiation. KCC2 also modulates chloride homeostasis by influencing the switch of GABA from depolarizing in young neurons to hyperpolarizing in mature neurons.
Oluwole B Akinola, Sharon L. Juliano, Francis T. Djankpa   +2 more
openaire   +2 more sources

Role of KCC2 in Auditory Processing of the Brainstem

2006
The present study indicates that the neuro-specific co-transporter KCC2 is expressed abundantly throughout the IC. The postnatal expression pattern of KCC2 is upregulated in the IC as well as that in the neocortex, the hippocampus and the cerebellum. Considering the importance of this co-transporter on controlling auditory function, further studies are
Kiyoshi Kurokawa, Takaaki Nakamura, Motoi Kudo   +2 more
openaire   +2 more sources