Results 241 to 250 of about 9,762 (266)

Multifactorial approach is needed to unravel the maturation phases of human neurons derived from induced pluripotent stem cells. [PDF]

Sci Rep
Ben Mahmoud M, Rátkai A, Bauer K, Bencsik N, Szücs A, Schlett K, Tárnok K.   +6 more
europepmc   +1 more source

The brain-specific kinase LMTK3 regulates neuronal excitability by decreasing KCC2-dependent neuronal Cl^- extrusion. [PDF]

iScience
Cho N, Kontou G, Smalley JL, Bope C, Dengler J, Montrose K, Deeb TZ, Brandon NJ, Yamamoto T, Davies PA, Giamas G, Moss SJ.   +11 more
europepmc   +1 more source

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CRISPR‐Based KCC2 Upregulation Attenuates Drug‐Resistant Seizure in Mouse Models of Epilepsy

Annals of Neurology, 2023
The precise intervention of K‐Cl cotransporter isoform 2 (KCC2) as a promising target for drug‐resistant epilepsy remains elusive.
Jiaying Shi, Huhu Xin, Yuying Shao, Sijie Dai, Na Tan, Zhisheng Li, Fan Fei, Di Wu, Yi Wang, Yuan Ping, Zhong Chen   +10 more
semanticscholar   +1 more source

Neuronal Restrictive Silencing Element Is Found in the KCC2 Gene: Molecular Basis for KCC2-Specific Expression in Neurons

Journal of Neurophysiology, 2001
KCC2 is one of four known isoforms of the K-Cl cotransporter with an expression pattern restricted to neurons. It mediates efflux of Cl− across neuronal membranes and plays an important role in GABAergic and glycinergic neurotransmission. To understand the molecular basis for neuronal specificity of KCC2 expression, we isolated and sequenced portions ...
Michael F. Karadsheh, Eric Delpire
openaire   +2 more sources

KCC2, epileptiform synchronization, and epileptic disorders

Progress in Neurobiology, 2018
The K+-Cl- co-transporter KCC2 is a neuron-specific, Cl- extruder that uses K+ gradient for maintaining low intracellular [Cl-]. It is indeed well established that sustaining an outwardly-directed electrochemical Cl- gradient across the neuronal membrane is fundamental for a proper function of postsynaptic GABAA receptor signaling.
Patricia N. Awad, Massimo Avoli, Massimo Avoli, Shabnam Hamidi, Graziella Di Cristo   +4 more
openaire   +3 more sources

Therapeutic effects of KCC2 chloride transporter activation on detrusor overactivity in mice with spinal cord injury.

AJP - Renal Physiology, 2023
This study aimed to clarify whether the down regulation of K+-Cl-co-transporter 2 (KCC2) in the sacral parasympathetic nucleus (SPN) of the lumbosacral spinal cord, from which the efferent pathway innervating the bladder originates, causes cellular ...
Kyohei Watanabe, Masaru Ishibashi, Takahisa Suzuki, A. Otsuka, N. Yoshimura, H. Miyake, A. Fukuda   +6 more
semanticscholar   +1 more source

Towards a KCC2 blocker pharmacophore model

Bioorganic & Medicinal Chemistry Letters, 2012
A multi-disciplinary approach was used to identify the first pharmacophore model for KCC2 blockers: several physico-chemical studies such as XRD and NMR were combined to molecular modelling techniques, SAR analysis and synthesis of constrained analogues in order to determine a minimal conformational space regrouping few potential bioactive ...
Benoit Mathieu, Ledecq Marie, Kashinath Dhurke, Ananda Kumar Kanduluru, Florence Lebon, Anne Frycia, Cecile Pegurier, Sébastien Lengelé, Laurent Provins, Nathalie Bosman, Christian Wolff, Alain Wagner, Stéphane Meunier   +12 more
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Distribution and Cellular Localization of KCC2 in the Ferret Neocortex

Developmental Neuroscience, 2018
KCC2 (a brain-specific potassium-chloride cotransporter) affects development of the cerebral cortex, including aspects of neuronal migration and cellular maturation and differentiation. KCC2 also modulates chloride homeostasis by influencing the switch of GABA from depolarizing in young neurons to hyperpolarizing in mature neurons.
Oluwole B Akinola, Sharon L. Juliano, Francis T. Djankpa   +2 more
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Role of KCC2 in Auditory Processing of the Brainstem

2006
The present study indicates that the neuro-specific co-transporter KCC2 is expressed abundantly throughout the IC. The postnatal expression pattern of KCC2 is upregulated in the IC as well as that in the neocortex, the hippocampus and the cerebellum. Considering the importance of this co-transporter on controlling auditory function, further studies are
Kiyoshi Kurokawa, Takaaki Nakamura, Motoi Kudo   +2 more
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Behavioural phenotypes of hypomorphic KCC2‐deficient mice

European Journal of Neuroscience, 2005
AbstractHyperpolarizing fast inhibitory neurotransmission by γ‐aminobutyric acid and glycine requires an efficient chloride extrusion mechanism in postsynaptic neurons. A major effector of this task in adult animals is the potassium‐chloride co‐transporter KCC2 that is selectively and abundantly expressed postsynaptically in most CNS neurons.
Heikki Rauvala, Harri Savilahti, Matti S. Airaksinen, Janne Tornberg, Vootele Voikar   +4 more
openaire   +3 more sources