Results 91 to 100 of about 10,273 (224)

p‐Cymene Targets Multiple Oncogenic Pathways in Hepatocellular Carcinoma: Insights From Network Pharmacology and In Vitro Studies

Food Science &Nutrition, Volume 13, Issue 10, October 2025.
p‐Cymene exhibited a strong affinity for key hepatocellular carcinoma (HCC) targets and induced dose‐dependent cytotoxicity in HepG2 cells while enhancing antioxidant defense mechanisms. The treatment significantly modulated apoptotic and angiogenic markers, notably increasing Caspase‐3 and p53, and suppressing BCL2 and VEGF expression.
Nadia Anwar, Muhammad Nasir Hayat Malik, Muhammad Atif, Abdullah R. Alanzi, Hattan A. Alharbi, Waqas Younis, Munawar Abbas, Gideon F. B. Solre   +7 more
wiley   +1 more source

Initial investigations into single nucleotide polymorphisms and their association with QTc and left ventricular function in peripartum cardiomyopathy

European Journal of Heart Failure, EarlyView.
Gasnat Shaboodien, Charle Viljoen, Polycarp Ndibangwi, Julian Hoevelmann, Lameez Pearce, Susanna Haidari, Margherita Torchio, Federica Dagradi, Carla Spazzolini, Sarah Kraus, Ntobeko A.B. Ntusi, Peter J. Schwartz, Karen Sliwa   +12 more
wiley   +1 more source

Generation and characterization of an induced pluripotent stem cell (iPSC) line (NUIGi003-A) from a long QT syndrome type 2 (LQT2) patient harbouring the KCNH2 c.2464G>A pathogenic variant

Stem Cell Research, 2020
Long QT syndrome (LQTS), an inherited cardiac ion channelopathy, is associated with ventricular arrhythmias and risk of sudden death. LQTS sub-type 2 (LQT2) is caused by pathogenic variants in KCNH2 encoding the α-subunit of Kv11.1, thus affecting the ...
Ning Ge, Min Liu, Janusz Krawczyk, Veronica McInerney, Deirdre Ward, Sanbing Shen, Timothy O'Brien, Terence Prendiville   +7 more
doaj   +1 more source

Pharmacogenetics of Drug-Induced QT Interval Prolongation: An Update [PDF]

, 2015
A prolonged QT interval is an important risk factor for ventricular arrhythmias and sudden cardiac death. QT prolongation can be caused by drugs. There are multiple risk factors for drug-induced QT prolongation, including genetic variation.
Berg, M.E. (Marten) van den, Eijgelsheim, M. (Mark), Niemeijer, M.N. (Maartje), Rijnbeek, P.R. (Peter), Stricker, B.H.Ch. (Bruno)   +4 more
core   +1 more source

Recurrent Takotsubo Cardiomyopathy With Variable Patterns and Psychiatric Comorbidities: A Case Report and Comprehensive Literature Review

Clinical Case Reports, Volume 13, Issue 7, July 2025.
ABSTRACT Takotsubo cardiomyopathy (TTC) is a transient stress‐induced cardiac syndrome that can mimic acute coronary syndrome but typically lacks obstructive coronary disease. We report a case of a 50‐year‐old woman with complex psychiatric comorbidities who developed classical apical TTC following acute emotional distress—distinct from a prior reverse
Hamza AlKowatli, Oubada Alkowatli, Ahmad Karzoun, Bisher Sawaf, Mhd Baraa Habib, Nahush Bansal, Muhammad Faiz, Robert Subbiondo   +7 more
wiley   +1 more source

Congenital Short QT Syndrome [PDF]

, 2004
Long QT intervals in the ECG have long been associated with sudden cardiac death. The congenital long QT syndrome was first described in individuals with structurally normal hearts in 1957.1 Little was known about the significance of a short QT interval.
Antzelevitch, Charles, Francis, Johnson
core   +1 more source

Next-generation sequencing using microfluidic PCR enrichment for molecular autopsy. [PDF]

, 2019
BACKGROUND: We aimed to determine the mutation yield and clinical applicability of "molecular autopsy" following sudden arrhythmic death syndrome (SADS) by validating and utilizing low-cost high-throughput technologies: Fluidigm Access Array PCR ...
Arno, G, Behr, ER, Christiansen, M, Cohen, MC, Hedley, PL, Jeffery, S, John, S, Li, X, Love, DR, Raju, H, Sharma, S, Sheppard, MN, Skinner, JR, Tfelt-Hansen, J, van der Werf, C, Ware, JS, Wilde, AAM, Winkel, BG   +17 more
core   +3 more sources

Case Report of Long QT Syndrome in a Patient With Syncope

The Kaohsiung Journal of Medical Sciences, EarlyView.
Chun‐Yu Chen, Rui‐Xian Wang, Ken‐Pen Weng, Shih‐Ming Huang   +3 more
wiley   +1 more source

Position of Premature Termination Codons Determines Susceptibility of hERG Mutations to Nonsense-Mediated mRNA Decay in Long QT Syndrome

, 2014
The degradation of human ether-a-go-go-related gene (hERG, KCNH2) transcripts containing premature termination codon (PTC)mutations by nonsense-mediatedmRNA decay (NMD) is an importantmechanismof long QT syndrome type 2 (LQT2).
Gong, Qiuming, Stump, Matthew R., Zhou, Zhengfeng   +2 more
core   +1 more source

SUDDEN UNEXPLAINED JUVENILE DEATH AND THE ROLE OF MEDICOLEGAL INVESTIGATION: UPDATE ON MOLECULAR AUTOPSY [PDF]

, 2012
In the past few years, contributions of molecular biology assays to the investigation of sudden juvenile death have permitted to clarify some of the pathogenetic aspects of sud-den arrhythmic death, opening the way to preventive action on victims ...
ARGO, Antonina, AVERNA, Letizia, PROCACCIANTI, Paolo, SORTINO, Cettina, ZERBO, Stefania   +4 more
core   +1 more source