Results 71 to 80 of about 9,233 (239)

Population‐Based Study Found Low Risk of Misdiagnosing Long QT Syndrome as Breath‐Holding Spells in Swedish Children

Acta Paediatrica, EarlyView.
ABSTRACT Aim An electrocardiogram is commonly recommended in breath‐holding spell management, mainly to rule out long QT syndrome. This retrospective study investigated the risk of long QT syndrome being misdiagnosed as breath‐holding spells in a paediatric population in southern Sweden.
Sanna Hellström Schmidt, Ida Jeremiasen, Erik A. Eklund, Cornelis Jan Pronk   +3 more
wiley   +1 more source

Case Report: Biventricular Noncompaction Cardiomyopathy With Pulmonary Stenosis and Bradycardia in a Fetus With KCNH2 Mutation

Frontiers in Genetics, 2022
Background: Left ventricular noncompaction (LVNC) is a rare cardiomyopathy, long QT syndrome (LQTS) is a rare ion channel disease, and simultaneous occurrence of both is even rarer.
Hairui Sun, Xiaowei Liu, Xiaoyan Hao, Xiaoxue Zhou, Jingyi Wang, Jiancheng Han, Mengmeng Liang, Hongjia Zhang, Yihua He   +8 more
doaj   +1 more source

Proliferative role of Kv11 channels in murine arteries [PDF]

, 2017
K+ channels encoded by the ether-a-go-go related gene (ERG1 or KCNH2) are important determinants of the cardiac action potential. Expression of both cardiac isoforms (ERG1 and ERG1b) were identified in murine portal vein and distinctive voltage-gated K ...
Abbott, Akbarali, Arcangeli, Babcock, Casis, Cidad, Curran, Doggrell, Farrelly, Greenwood, Guasti, Hansen, Haushalter, Iannotti, Larsen, Larsen, Lees-Miller, London, Mazhari, McCrossan, Mewe, Mulvany, Ohya, Pardo, Parr, Phartiyal, Pond, Rajamani, Sale, Shi, Smith, Spector, Vandenberg, Yeung, Yeung, Zhou   +35 more
core   +3 more sources

Cancer Hallmarks Expression in Oral Leukoplakia: Systematic Review and Meta‐Analysis

Oral Diseases, EarlyView.
ABSTRACT Objectives To assess the available evidence on the expression of hallmarks of cancer and oral leukoplakia (OL) malignant transformation probability, with the goal of identifying the earliest oncogenic molecular events participating in oral cancer carcinogenesis.
I. González‐Ruiz, P. Ramos‐García, H. Boujemaoui‐Boulaghmoudi, N. Mjouel‐Boutaleb, M. A. González‐Moles   +4 more
wiley   +1 more source

Association between antihypertensive drugs and oral cancer: a drug target Mendelian randomization study

Frontiers in Pharmacology, 2023
Background: Recent reports have suggested that antihypertensive drugs may play an oncogenic role in common cancers, but it is still uncertain whether this could influence the risk of oral cancer. Through two-sample Mendelian randomization (MR), we sought
Junfeng Guo, Junfeng Guo, Rongxing Liu, Fangfang Sheng, Qiuxiang Wu, Rufu Xu, Haitao He, Gang Zhang, Junjie Huang, Zhe Zhang, Rong Zhang   +10 more
doaj   +1 more source

MicroRNAs in cardiac arrhythmia: DNA sequence variation of MiR-1 and MiR-133A in long QT syndrome. [PDF]

, 2014
Long QT syndrome (LQTS) is a genetic cardiac condition associated with prolonged ventricular repolarization, primarily a result of perturbations in cardiac ion channels, which predisposes individuals to life-threatening arrhythmias.
Anting L. Carlsen, Bartel DP, Bentwich I, Biesecker LG, Borel C, Care A, Carlsen AL, Carthew RW, Christiansen M, Christiansen M, Crotti L, Dorn GW, Elijah R. Behr, Filipowicz W, Friedman RC, Genomes Project C, Goldenberg I, Gruber AR, Hall TA, Hedley PL, Hedley PL, Hofman-Bang J, Jørgen K. Kanters, Kasper M. Christiansen, Kim GH, Kim J, Krek A, Lagos-Quintana M, Lagos-Quintana M, Larsen LA, Larsen LA, Lee RC, Lewis BP, Lewis BP, Lim LP, Liu N, Liu N, Liu N, Luo X, Matkovich SJ, Mencia A, Michael Christiansen, Ohanian M, Paula L. Hedley, Poy MN, Poy MN, Rajewsky N, Raymond M, Rousset F, Ryan BM, Saunders MA, Small EM, Terentyev D, Valencia-Sanchez MA, Valerie A. Corfield, Xiao L, Yang Y, Ye J, Zhao Y, Zhao Y   +59 more
core   +1 more source

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source

Síndrome do QT longo: mutação trigénica, um caso raro

Revista Portuguesa de Cardiologia, 2015
Resumo: A síndrome do QT longo congénito (SQTLC) é uma doença hereditária rara, com uma incidência de uma em cada 2000 pessoas, caracterizada por uma repolarização ventricular prolongada e por taquiarritmias ventriculares malignas.Reportamos o caso de ...
Marina Fernandes, Sílvia Martins Ribeiro, Victor Sanfins, António Lourenço   +3 more
doaj   +1 more source

Drug-mediated shortening of action potentials in LQTS2 hiPSC-cardiomyocytes [PDF]

, 2017
Cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) are now a well-established modality for modeling genetic disorders of the heart.
Denning, Chris, Duncan, Gary, Firth, Karl S.A., George, Vinoj, Hoang, Minh Duc, Smith, Godfrey, Stainforth, Andrew   +6 more
core   +3 more sources

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies.
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source