Results 81 to 90 of about 10,273 (224)

Key role for Kv11.1 (ether‐a‐go‐go related gene) channels in rat bladder contractility

Physiological Reports, 2023
In addition, to their established role in cardiac myocytes and neurons, ion channels encoded by ether‐a‐go‐go‐related genes (ERG1‐3 or kcnh2,3 and 6) (kcnh2) are functionally relevant in phasic smooth muscle.
Vincenzo Barrese, Zena Wehbe, Alice Linden, Sarah McDowell, Elizabeth Forrester, Oleksander Povstyan, Karen D. McCloskey, Iain A. Greenwood   +7 more
doaj   +1 more source

Arrhythmogenic Effects of Genetic Mutations Affecting Potassium Channels in Human Atrial Fibrillation: A Simulation Study

Frontiers in Physiology, 2021
Genetic mutations in genes encoding for potassium channel protein structures have been recently associated with episodes of atrial fibrillation in asymptomatic patients.
Rebecca Belletti, Lucia Romero, Laura Martinez-Mateu, Elizabeth M. Cherry, Flavio H. Fenton, Javier Saiz   +5 more
doaj   +1 more source

Cardiac electrical defects in progeroid mice and Hutchinson-Gilford progeria syndrome patients with nuclear lamina alterations [PDF]

, 2016
Hutchinson–Gilford progeria syndrome (HGPS) is a rare genetic disease caused by defective prelamin A processing, leading to nuclear lamina alterations, severe cardiovascular pathology, and premature death.
Benítez Iglesias, Raúl, Caballero, Ricardo, Cabello, Nuria, Calvo, Conrado J., González Gómez, Cristina, Gordon, Leslie B., Guadix, Juan A., Gúzman Martínez, Gabriela, Herraiz Martínez, Adela, Jiménez Borreguero, Luís J., Llach, Anna, López Otín, Carlos, Osorio, Fernando G., Riveras Torres, Jose, Vallmitjana Lees, Alexander   +14 more
core   +2 more sources

Bradycardia in a long QT type 2 family: coinciding KCNH2 and HCN4 variants

Cardiovascular Research
Type of funding sources: Public grant(s) – National budget only. Main funding source(s): the Dutch Research Council: NWO Talent Scheme A large multigenerational family harboring a pathogenic KCNH2 variant (L69P) was identified.
J. Copier, K. Andrzejczyk, A. S. Amin, S. N. Van Der Crabben, L. Beekman, C. Bezzina, A. Verkerk, E. Lodder   +7 more
semanticscholar   +1 more source

Quinoa Ameliorates High‐Fat Diet‐Induced Obesity in Female Mice by Regulating Gut Microbiota and Adipogenesis

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
Quinoa intervention counteracts high‐fat diet (HFD)‐induced obesity in C57BL/6 female mice and elicits a concomitant increase in the relative abundance of Bacteroidota, Bacteroidia, Bacteroidales, and Muribaculaceae. Treatment with quinoa in HFD‐fed female mice results in reduced expression of genes involved in “ion channel” in gonadal white adipose ...
Yingqi Liu, Qiwen Pan, Xiaohua Bao, Yingxin Zhang, Xianjun Liu, Yue Liu, Yujie Liu, Yingxin Zhang, Qirui Xie, Zhiyong Liang, Fengjie Sun, Jing Li, Hao Li, Zhandong Li   +13 more
wiley   +1 more source

Síndrome do QT longo: mutação trigénica, um caso raro

Revista Portuguesa de Cardiologia, 2015
Resumo: A síndrome do QT longo congénito (SQTLC) é uma doença hereditária rara, com uma incidência de uma em cada 2000 pessoas, caracterizada por uma repolarização ventricular prolongada e por taquiarritmias ventriculares malignas.Reportamos o caso de ...
Marina Fernandes, Sílvia Martins Ribeiro, Victor Sanfins, António Lourenço   +3 more
doaj   +1 more source

Circadian Rhythm: Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 6, Issue 11, November 2025.
This review offers a comprehensive overview of the mechanisms by which circadian rhythms modulate tissue homeostasis, alongside the associations between circadian disturbances and circadian rhythm‐related diseases. Furthermore, we offer insights into circadian rhythm‐regulating therapies, which may contribute to the development of novel strategies for ...
Kangkang Zha, Bobin Mi, Yuan Xiong, Shuyan Wu, Li Lu, Shengming Zhang, Xuan Lu, Hei Chung Mak, Jianping Huang, Adriana C. Panayi, Samuel Knoedler, Lili Chen, Guohui Liu, Sien Lin   +13 more
wiley   +1 more source

Proliferative role of Kv11 channels in murine arteries [PDF]

, 2017
K+ channels encoded by the ether-a-go-go related gene (ERG1 or KCNH2) are important determinants of the cardiac action potential. Expression of both cardiac isoforms (ERG1 and ERG1b) were identified in murine portal vein and distinctive voltage-gated K ...
Abbott, Akbarali, Arcangeli, Babcock, Casis, Cidad, Curran, Doggrell, Farrelly, Greenwood, Guasti, Hansen, Haushalter, Iannotti, Larsen, Larsen, Lees-Miller, London, Mazhari, McCrossan, Mewe, Mulvany, Ohya, Pardo, Parr, Phartiyal, Pond, Rajamani, Sale, Shi, Smith, Spector, Vandenberg, Yeung, Yeung, Zhou   +35 more
core   +3 more sources

Nonsteroidal Anti‐Inflammatory Drugs as Modulators of Cation Channels: Fenamates Repurposing in Channelopathies

ChemMedChem, Volume 20, Issue 20, October 15, 2025.
Beyond their established role as nonsteroidal anti‐inflammatory drugs (NSAIDs), fenamates (niflumic, flufenamic, mefenamic, meclofenamic, and tolfenamic acids) have recently been identified as modulators of cationic ion channels. This review highlights their differential effects on ion channel activity and explores their potential for repurposing in ...
Paola Laghetti, Concetta Altamura, Simone Dell’Atti, Jean‐François Desaphy, Ilaria Saltarella   +4 more
wiley   +1 more source

Genotype-Phenotype Relationships in Long QT Syndrome : Role of Mental Stress, Adrenergic Activity and a Common KCNH2 Polymorphism [PDF]

, 2006
Long QT syndrome is a congenital or acquired arrhythmic disorder which manifests as a prolonged QT-interval on the electrocardiogram and as a tendency to develop ventricular arrhythmias which can lead to sudden death.
Paavonen, Kristian
core