Results 81 to 90 of about 9,256 (240)

Drug-mediated shortening of action potentials in LQTS2 hiPSC-cardiomyocytes [PDF]

, 2017
Cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) are now a well-established modality for modeling genetic disorders of the heart.
Denning, Chris, Duncan, Gary, Firth, Karl S.A., George, Vinoj, Hoang, Minh Duc, Smith, Godfrey, Stainforth, Andrew   +6 more
core   +3 more sources

Bioprinted Excitable Tissues with Multistimulation Systems for Promoting Function and Maturation

Advanced NanoBiomed Research, Volume 6, Issue 3, March 2026.
This review provides an overview of stimulation strategies used to enhance the functional maturation of bioprinted excitable tissues. It addresses key limitations in physiological performance of bioprinted excitable tissues, outlines major stimulation modalities—including electrical, mechanical, optical, magnetic, ultrasound, and hybrid—and examines ...
Uijung Yong, Jinseon Park, Jinah Jang
wiley   +1 more source

Key role for Kv11.1 (ether‐a‐go‐go related gene) channels in rat bladder contractility

Physiological Reports, 2023
In addition, to their established role in cardiac myocytes and neurons, ion channels encoded by ether‐a‐go‐go‐related genes (ERG1‐3 or kcnh2,3 and 6) (kcnh2) are functionally relevant in phasic smooth muscle.
Vincenzo Barrese, Zena Wehbe, Alice Linden, Sarah McDowell, Elizabeth Forrester, Oleksander Povstyan, Karen D. McCloskey, Iain A. Greenwood   +7 more
doaj   +1 more source

Cardiac Manifestations of KCNK17 Mutations and/or Polymorphisms: A Systematic Review

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background and Aims The KCNK17 gene encodes k2p17.1 channels (TASK‐4 or TALK‐2) with dominant expressions in the atria and the Purkinje fibers. Emerging studies have suggested possible associations between KCNK17 variants and cardiovascular as well as cerebrovascular diseases. This review aimed to systematically evaluate the evidence on KCNK17
Amir Askarinejad, Mahshid Malakootian, Dorsa Shekouh, Amirreza Sabahizadeh, Majid Haghjoo   +4 more
wiley   +1 more source

Proliferative role of Kv11 channels in murine arteries [PDF]

, 2017
K+ channels encoded by the ether-a-go-go related gene (ERG1 or KCNH2) are important determinants of the cardiac action potential. Expression of both cardiac isoforms (ERG1 and ERG1b) were identified in murine portal vein and distinctive voltage-gated K ...
Abbott, Akbarali, Arcangeli, Babcock, Casis, Cidad, Curran, Doggrell, Farrelly, Greenwood, Guasti, Hansen, Haushalter, Iannotti, Larsen, Larsen, Lees-Miller, London, Mazhari, McCrossan, Mewe, Mulvany, Ohya, Pardo, Parr, Phartiyal, Pond, Rajamani, Sale, Shi, Smith, Spector, Vandenberg, Yeung, Yeung, Zhou   +35 more
core   +3 more sources

Quantitative Histological Insights Into Sudden Arrhythmic Death Syndrome: Findings From a Forensic Autopsy Cohort

APMIS, Volume 134, Issue 3, March 2026.
ABSTRACT Sudden arrhythmic death syndrome (SADS) is a major cause of sudden cardiac death in young individuals, characterized by structurally normal hearts and negative toxicology. Although guidelines recommend family screening, phenotyping remains challenging.
Pernille Heimdal Holm, Thomas Hartvig Lindkær Jensen, Joseph Westaby, Mary Sheppard, Stine Bøttcher Jacobsen, Mikkel Eriksen Dupont, Jeppe Dyrberg Andersen, Bo Gregers Winkel, Jacob Tfelt‐Hansen, Jytte Banner, Kristine Boisen Olsen   +10 more
wiley   +1 more source

Long QT syndrome KCNH2 mutation with sequential fetal and maternal sudden death [PDF]

Forensic Science, Medicine and Pathology, 2018
We report a case of a woman who experienced intrauterine fetal death at full term pregnancy, and then died suddenly soon after learning about the death of her fetus. At autopsy, previously undiagnosed neurofibromatosis and an adrenal gland pheochromocytoma were discovered in the mother.
Tuveng, Jon M., Berling, Britt-Marie, Bunford, Gabor, Vanoye, Carlos G, Welch, Richard C, Leren, Trond Paul, George, Alfred L., Rognum, Torleiv Ole   +7 more
openaire   +3 more sources

Mutual Exclusion Analysis Shows that DUSP9 Negatively Regulates PD‐L1 Expression and Acts as a Target to Enhance Anti‐PD‐1 Efficacy

Advanced Science, Volume 13, Issue 12, 27 February 2026.
A mutually exclusive screening system is established to identify negative regulators of highly plastic genes. Dual specificity phosphatase (DUSP9) is a novel negative regulatory molecule of PD‐L1 by dephosphorylating STAT3, and acts as a target molecule in combination with PD‐1 antibody for tumor immunotherapy and a new clinical biomarker for ...
Yuzhe Hu, Ling Tang, Zheng Kuang, Danyi Huang, Ting Li, Gaofei Yin, Yingyu Chen, Wei Guo, Wenling Han, Pingzhang Wang   +9 more
wiley   +1 more source

Generation of a human embryonic stem cell line (WAe009-A-43) carrying a Long QT syndrome related mutation in KCNH2 gene

Stem Cell Research, 2020
The hereditary Long QT syndrome (LQTS) is a life-threaten channelopathy of the heart characterized by prolonged QT intervals and predisposition to occur polymorphic ventricular tachyarrhythmias.
Xiaodan Wu, Yitong Zhao, Xiantao Wang
doaj   +1 more source

Genotype-Phenotype Relationships in Long QT Syndrome : Role of Mental Stress, Adrenergic Activity and a Common KCNH2 Polymorphism [PDF]

, 2006
Long QT syndrome is a congenital or acquired arrhythmic disorder which manifests as a prolonged QT-interval on the electrocardiogram and as a tendency to develop ventricular arrhythmias which can lead to sudden death.
Paavonen, Kristian
core