Results 61 to 70 of about 3,106 (169)

Idiopathic epilepsy of childhood and potassium ion channels [PDF]

, 2007
Potassium can affect the development of common seizure type and can be defined seizure susceptibility allele. The existence of inward-rectifying potassium (Kir) channels was first recognized half a century ago. The biophysical fingerprint of Kir channels
Dai, Alper I, Wasay, Mohammad
core   +1 more source

Src Family Protein Tyrosine Kinase Regulates the Basolateral K Channel in the Distal Convoluted Tubule (DCT) by Phosphorylation of KCNJ10 Protein

Journal of Biological Chemistry, 2013
The loss of function of the basolateral K channels in the distal nephron causes electrolyte imbalance. The aim of this study is to examine the role of Src family protein tyrosine kinase (SFK) in regulating K channels in the basolateral membrane of the mouse initial distal convoluted tubule (DCT1).
Chengbiao, Zhang, Lijun, Wang, Sherin, Thomas, Kemeng, Wang, Dao-Hong, Lin, Jesse, Rinehart, Wen-Hui, Wang   +6 more
openaire   +2 more sources

Neuronal THY1 Signaling Maintains Astrocytes in a Quiescent State

Glia, Volume 74, Issue 1, January 2026.
THY1‐bearing neurons keep astrocytes in a quiescent state via the interaction with ITGB1. Depletion of THY1 supports the development of a partially activated astrocyte phenotype. Neuronal THY1 is involved in the maintenance and restoration of tissue homeostasis in the brain. ABSTRACT THY1 is a cell surface protein of mature neurons.
Juliane Loui, Ute Krügel, Ulrike Winkler, Anja Reinert, Dorit John, Johannes Hirrlinger, Anja Saalbach   +6 more
wiley   +1 more source

Effects of AQP4 and KCNJ10 Gene Polymorphisms on Drug Resistance and Seizure Susceptibility in Chinese Han Patients with Focal Epilepsy

Neuropsychiatric Disease and Treatment, 2020
Haoyue Zhu, Mengqi Zhang, Yujiao Fu, Hongyu Long, Wenbiao Xiao, Li Feng, Bo Xiao, Luo Zhou Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, People’s Republic of ChinaCorrespondence: Luo ZhouDepartment of ...
Zhu H, Zhang M, Fu Y, Long H, Xiao W, Feng L, Xiao B, Zhou L   +7 more
doaj  

Endogenous Retrovirus Insertion in the KIT Oncogene Determines White and White spotting in Domestic Cats [PDF]

, 2014
The Dominant White locus (W) in the domestic cat demonstrates pleiotropic effects exhibiting complete penetrance for absence of coat pigmentation and incomplete penetrance for deafness and iris hypopigmentation.
Connelly, Catherine J., Coots Wallace, Andrea, David, Victor A., Eizirik, Eduardo, Hannah, Steven S., Kehler, James, Leighty, Robert, Menotti-Raymond, Marilyn, Nelson, George, O\u27Brien, Stephen J., Roelke, Melody E., Ryugo, David K., Schaffer, Alejandro A.   +12 more
core   +2 more sources

Possible Roles of the Weakly Inward Rectifying K+ Channel Kir4.1 (KCNJ10) in the Pre-Bötzinger Complex

, 2008
Rhythmic activity of respiratory neurons is dependent on the clearance of neurotransmitter by astrocytes. Astrocytes should also be involved in the permanent and rapid clearance of extracellular ions. We analyzed the expression of the weakly inwardly rectifying K+ channel Kir4.1 (KCNJ10) in the respiratory network and studied the possible functions for
Papadopoulos, Nestoras, Winter, Stefan M., Haertel, Kai, Kaiser, Melanie, Neusch, Clemens, Huelsmann, Swen   +5 more
openaire   +3 more sources

Kcnj10 is a major type of K⁺ channel in mouse corneal epithelial cells and plays a role in initiating EGFR signaling

American Journal of Physiology-Cell Physiology, 2014
We used primary mouse corneal epithelial cells (pMCE) to examine the role of Kcnj10 in determining membrane K+ conductance and cell membrane potential and in regulating EGF/TGFA release. Western blot, immunostaining, and RT-PCR detected the expression of Kcnj10 in mouse cornea.
Lijun, Wang, Chengbiao, Zhang, Xiaotong, Su, Daohong, Lin   +3 more
openaire   +3 more sources

Single‐Nucleus Transcriptomics Uncovers Xaf1‐Driven PANoptosis as a Therapeutic Target in Aminoglycoside‐Induced Hearing Loss

Cell Proliferation, Volume 59, Issue 1, January 2026.
Neomycin induces increased expression of Xaf1 in cochlear HCs, triggering PANoptosis, which encompasses pyroptosis, apoptosis and necroptosis (left). Targeted Xaf1 knockdown in HCs through gene therapy can significantly inhibit the occurrence of PANoptosis in HCs (right).
Xinlin Wang, Hairong Xiao, Jiheng Wu, Yanqin Lin, Yiheng Ao, Zixuan Ye, Xin Tan, Fanliang Kong, Xin Chen, Renjie Chai, Shasha Zhang   +10 more
wiley   +1 more source

Optical mapping of neuronal activity during seizures in zebrafish [PDF]

, 2017
Mapping neuronal activity during the onset and propagation of epileptic seizures can provide a better understanding of the mechanisms underlying this pathology and improve our approaches to the development of new drugs.
Fornetto, C, M\ufcllenbroich, M. C, Mannaioni, G, Marchetto, Giulia, Masi, A, Pavone, F. S, Resta, F, Tiso, Natascia, Turrini, L, Vanzi, F., Vettori, Andrea   +10 more
core   +3 more sources

The disruption of KCNJ10 stimulates the expression of Na‐activated K channel in the basolateral membrane of the thick ascending limb

The FASEB Journal, 2015
Previous study has demonstrated that the disruption of Kcnj10 decreased the expression of NCC in the distal convoluted tubule (DCT). The aim of the present study is to examine the role of Kcnj10 in contributing to the basolateral K conductance in the cortical thick ascending limb (cTAL) using Kcnj10+/+ and ‐/‐ mice.
Chengbiao Zhang, Lijun Wang, Xiao‐tong Su, Dao‐hong Lin, Wen‐hui Wang   +4 more
openaire   +1 more source