Results 151 to 160 of about 3,925 (184)
Role of KCNQ Channels in Skeletal Muscle Arteries and Periadventitial Vascular Dysfunction
Hypertension, 2013 KCNQ channels have been identified in arterial smooth muscle. However, their role in vasoregulation and chronic vascular diseases remains elusive. We tested the hypothesis that KCNQ channels contribute to periadventitial vasoregulation in peripheral ...
Olga Zavaritskaya +2 more
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KCNQ-Encoded Potassium Channels as Therapeutic Targets
Annual Review of Pharmacology and Toxicology, 2018Kv7 channels are voltage-gated potassium channels encoded by KCNQ genes that have a considerable physiological impact in many cell types. This reliance upon Kv7 channels for normal cellular function, as well as the existence of hereditary disorders caused by mutations to KCNQ genes, means that pharmacological targeting of these channels has broad ...
Vincenzo Barrese +2 more
exaly +3 more sources
Nature Neuroscience, 2011
A study finds that the voltage-gated K+ channel KCNQ4 is expressed in a subset of rapidly adapting, low-threshold mechanoreceptors, where it shapes the response profile to dynamic tactile stimuli.
Clare H, Munns, Michael J, Caterina
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A study finds that the voltage-gated K+ channel KCNQ4 is expressed in a subset of rapidly adapting, low-threshold mechanoreceptors, where it shapes the response profile to dynamic tactile stimuli.
Clare H, Munns, Michael J, Caterina
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The therapeutic potential of neuronal KCNQ channel modulators
Expert Opinion on Therapeutic Targets, 2003Neuronal KCNQ (Kv7) channels (KCNQ2-5 or Kv7.2-7.5, disclosed to date) were discovered by virtue of their homology with a known cardiac channel involved in long QT syndrome (KvLQT or KCNQ1, Kv7.1) and first disclosed in 1998. The involvement of KCNQ2 (Kv7.2) and KCNQ3 (Kv7.3) in a benign idiopathic neonatal epilepsy, KCNQ4 (Kv7.4) in a form of ...
Valentin K Gribkoff
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In Silico Predictions of KCNQ Variant Pathogenicity in Epilepsy
Pediatric Neurology, 2021Variants in KCNQ2 and KCNQ3 may cause benign neonatal familial seizures and early infantile epileptic encephalopathy. Previous reports suggest that in silico models cannot predict pathogenicity accurately enough for clinical use. Here we sought to establish a model to accurately predict the pathogenicity of KCNQ2 and KCNQ3 missense variants based on ...
David M. Ritter +2 more
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Centipedes subdue giant prey by blocking KCNQ channels
Proceedings of the National Academy of Sciences of the United States of America, 2018 Centipedes can subdue giant prey by using venom, which is metabolically expensive to synthesize and thus used frugally through efficiently disrupting essential physiological systems.
Ping Liang, Ming Zhou, Xiaochen Wang
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Design and evaluation of pyrazolopyrimidines as KCNQ channel modulators
Bioorganic & Medicinal Chemistry Letters, 2019Effective treatments of neuropathic pain have been a focus of many discovery programs. KCNQ (kv7) are voltage gated potassium channel openers that have the potential for the treatment of CNS disorders including neuropathic pain. Clinical studies have suggested agents such as Retigabine to be a modulator of pain-like effects such as hyperalgesia and ...
Augustine T, Osuma +4 more
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Recent Developments on KCNQ Potassium Channel Openers
Current Medicinal Chemistry, 2005During the past five years, several members of the KCNQ potassium channel gene family have been identified with a high degree of CNS specificity. Within the KCNQ family, the combination of the KCNQ2/KCNQ3 proteins, and the KCNQ5/KCNQ3 arrangement has been identified as the molecular correlates of the different M-currents.
Yong-Jin, Wua, Steven I, Dworetzky
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Expression and function of KCNQ channels in larval zebrafish
Developmental Neurobiology, 2012AbstractMembers of the Kv7 family generate a subthreshold potassium current, termed M‐current, that regulates the excitability of principal central neurons. Mutations in two members of this family, Kv7.2 (KCNQ2) and Kv7.3 (KCNQ3) are associated with a neurological disorder known as benign familial neonatal convulsion (BFNC). Despite their importance in
Sally W, Chege +3 more
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KCNE Regulation of KCNQ Channels
2020Voltage-gated potassium (Kv) channels are perhaps best known for their roles in the action potentials of excitable cells, but they also fulfill a diverse array of vital roles in polarized epithelial cells. Much of the research and current knowledge in this area centers on the KCNQ1 potassium channel and the KCNE family of regulatory proteins.
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