Results 71 to 80 of about 800,175 (138)

Hydroxycarboxylic Acid Receptor 2 Mediates β‐hydroxybutyrate's Antiseizure Effect in Mice

Annals of Neurology, Volume 99, Issue 3, Page 809-824, March 2026.
A[Color figure can be viewed at www.annalsofneurology.org] Objective The ketogenic diet, a high‐fat, low‐carbohydrate regimen, is often used to treat drug‐resistant seizures and is being studied for Alzheimer's disease and other neuropsychiatric disorders. However, its mechanism of action remains unclear. β‐hydroxybutyrate, a primary circulating ketone
Soudabeh Naderi, John Williamson, Huayu Sun, Suchitra Joshi, Rachel Jane Spera, Savaira Zaib, Supriya Sharma, Chengsan Sun, Andrey Brodovskiy, Ifrah Zawar, Jaideep Kapur   +10 more
wiley   +1 more source

Elucidation of the zinc binding site in KCNQ channels [PDF]

Background and Purpose KCNQ1-5 (Kv7.1–7.5) are members of a family of voltage-gated potassium channels with prominent function in the nervous and cardiovascular systems and in epithelia.
Zhang, S., Yang, X., Cao, Y., Gamper, N., Shi, S., Yang, M., Gao, H.   +6 more
core   +1 more source

Whole-exome sequencing identifies two novel mutations in KCNQ4 in individuals with nonsyndromic hearing loss

Scientific Reports, 2018
Mutations in potassium voltage-gated channel subfamily Q member 4 (KCNQ4) are etiologically linked to a type of nonsyndromic hearing loss, deafness nonsyndromic autosomal dominant 2 (DFNA2).
Jinsei Jung, Hyun Been Choi, Young Ik Koh, John Hoon Rim, Hye Ji Choi, Sung Huhn Kim, Jae Hyun Lee, Jieun An, Ami Kim, Joon Suk Lee, Sun Young Joo, Seyoung Yu, Jae Young Choi, Tong Mook Kang, Heon Yung Gee   +14 more
doaj   +1 more source

Direct neurotransmitter activation of voltage-gated potassium channels

Nature Communications, 2018
M-current is conveyed by voltage-sensitive KCNQ channels, which are enriched in GABAergic neurons and are activated by anticonvulsants such as retigabine.
Rían W. Manville, Maria Papanikolaou, Geoffrey W. Abbott   +2 more
doaj   +1 more source

The Kv7 Channel and Cardiovascular Risk Factors

Frontiers in Cardiovascular Medicine, 2017
Potassium channels play a pivotal role in the regulation of excitability in cells such as neurons, cardiac myocytes, and vascular smooth muscle cells.
Andreas L. Fosmo, Øyvind B. Skraastad
doaj   +1 more source

Medicinal plant rosemary relaxes blood vessels by activating vascular smooth muscle KCNQ channels. [PDF]

FASEB J, 2023
Manville RW, Baldwin SN, Eriksen EØ, Jepps TA, Abbott GW.   +4 more
europepmc   +1 more source

The M-Channel Blocker Linopirdine Is an Agonist of the Capsaicin Receptor TRPV1

Journal of Pharmacological Sciences, 2010
.: Linopirdine is a well known blocker of voltage-gated potassium channels from the Kv7 (or KCNQ) family that generate the so called M current in mammalian neurons.
Cristian Neacsu, Alexandru Babes
doaj   +1 more source

A Role for KCNQ Channels on Cell Type-Specific Plasticity in Mouse Auditory Cortex after Peripheral Damage. [PDF]

J Neurosci, 2023
Henton A, Zhao Y, Tzounopoulos T.
europepmc   +1 more source

The role of DPO-1 and XE991-sensitive potassium channels in perivascular adipose tissue-mediated regulation of vascular tone

Frontiers in Physiology, 2016
The anti-contractile effect of perivascular adipose tissue (PVAT) is an important mechanism in the modulation of vascular tone in peripheral arteries. Recent evidence has implicated the XE991-sensitive voltage-gated Kv (KCNQ) channels in the regulation ...
Dmitry Tsvetkov, Jean-Yves Tano, Mario Kassmann, Ning Wang, Rudolf Schubert, Maik Gollasch, Maik Gollasch   +6 more
doaj   +1 more source

The role of KCNQ channels in the thalamus

, 2013
Der ventrobasale thalamische Komplex (VB) spielt eine entscheidende Rolle bei der somatosensorischen Informationsverarbeitung und ist insbesondere wichtig für die diskriminativen und räumlichen Aspekte der akuten Schmerzverarbeitung.
Cerina, M. (Manuela)
core   +2 more sources