Results 81 to 90 of about 800,175 (138)

KCNQ2/3/5 channels in dorsal root ganglion neurons can be therapeutic targets of neuropathic pain in diabetic rats

Molecular Pain, 2018
Background Diabetic neuropathic pain is poorly controlled by analgesics, and the precise molecular mechanisms underlying hyperalgesia remain unclear. The KCNQ2/3/5 channels expressed in dorsal root ganglion neurons are important in pain transmission. The
Ting Yu, Lei Li, Huaxiang Liu, Hao Li, Zhen Liu, Zhenzhong Li   +5 more
doaj   +1 more source

Electro-mechanical coupling of KCNQ channels is a target of epilepsy-associated mutations and retigabine. [PDF]

Sci Adv, 2022
Yang ND, Kanyo R, Zhao L, Li J, Kang PW, Dou AK, White KM, Shi J, Nerbonne JM, Kurata HT, Cui J.   +10 more
europepmc   +1 more source

KCNQ Channels Enable Reliable Presynaptic Spiking and Synaptic Transmission at High Frequency. [PDF]

J Neurosci, 2022
Zhang Y, Li D, Darwish Y, Fu X, Trussell LO, Huang H.   +5 more
europepmc   +1 more source

Activation of voltage-gated KCNQ/Kv7 channels by anticonvulsant retigabine attenuates mechanical allodynia of inflammatory temporomandibular joint in rats

Molecular Pain, 2010
Background Temporomandibular disorders (TMDs) are characterized by persistent orofacial pain and have diverse etiologic factors that are not well understood.
Xu Wen, Wu Yuwei, Bi Yeping, Tan Lei, Gan Yehua, Wang KeWei   +5 more
doaj   +1 more source

KCNQ Channels in the Mesolimbic Reward Circuit Regulate Nociception in Chronic Pain in Mice. [PDF]

Neurosci Bull, 2021
Wang HR, Hu SW, Zhang S, Song Y, Wang XY, Wang L, Li YY, Yu YM, Liu H, Liu D, Ding HL, Cao JL.   +11 more
europepmc   +1 more source

KCNQ channel opening as a powerful mechanism for vasodilation [PDF]

, 2011
KCNQ channels were recently found in the vascular system. We have tested the hypothesis that KCNQ channels are powerful targets for relaxation of small systemic and pulmonary arteries.
Zhuravleva, Nadezda (gnd: 1027084400)
core   +1 more source

Role of the C-terminal domain in the structure and function of tetrameric sodium channels [PDF]

, 2013
Voltage-gated sodium channels have essential roles in electrical signalling. Prokaryotic sodium channels are tetramers consisting of transmembrane (TM) voltage-sensing and pore domains, and a cytoplasmic carboxy-terminal domain.
Clapham, D.E., Hall, Benjamin A., Wallace, Bonnie A., Claire E. Naylor, Christopher W. M. Kay, Paul G. Decaen, Clapham, David, Hall, B.A., Wallace, B. A., DeCaen, P.G., Naylor, Claire E., Benjamin A. Hall, B. A. Wallace, Bagneris, Claire, Kay, C.W.M., DeCaen, Paul, David E. Clapham, Kay, Christopher W. M.   +17 more
core   +2 more sources

The function of KCNQ ion channels in pain and somatosensation

, 2016
Der durch KCNQ (Kv7) Kanäle vermittelte M-Strom spielt eine wichtige Rolle für elektrische Eigenschaften von Zellen. Als intrinsische Spannungsklemme stabilisieren KCNQ Kanäle demnach das Ruhemembranpotential und verhindern Übererregbarkeit, wie ...
Schütze, Sebastian
core   +1 more source

Involvement of HDAC2-mediated kcnq2/kcnq3 genes transcription repression activated by EREG/EGFR-ERK-Runx1 signaling in bone cancer pain

Cell Communication and Signaling
Bone cancer pain (BCP) represents a prevalent symptom among cancer patients with bone metastases, yet its underlying mechanisms remain elusive. This study investigated the transcriptional regulation mechanism of Kv7(KCNQ)/M potassium channels in DRG ...
Zi-Xian Zhang, Yue Tian, Song Li, Hong-Bo Jing, Jie Cai, Min Li, Guo-Gang Xing   +6 more
doaj   +1 more source

SMITten for KCNQ Channels. [PDF]

Biophys J, 2017
Tzingounis AV.
europepmc   +1 more source