Results 131 to 140 of about 32,637 (272)

Tumor Microenvironments in Malignant Ovarian Germ Cell Tumors: MHC Class I Loss and T‐Cell Exhaustion in Dysgerminoma

Cancer Science, Volume 117, Issue 2, Page 566-575, February 2026.
Malignant ovarian germ cell tumor subtypes exhibit distinct tumor microenvironments. Dysgerminomas harbor abundant nonexhausted T cells, with progenitor exhausted T cells present in 60% of PD‐1–positive cases. However, MHC class I expression is lost across all analyzed subtypes, suggesting that restoring class I expression in dysgerminomas may enhance ...
Miya Nakashima, Takeshi Iwasaki, Yoshihiro Katayama, Masatoshi Shimo, Ken Takigawa, Naomi Shimada, Michiko Matsushita, Satoshi Kuwamoto, Shinya Sato, Masato Toya, Kohta Miyawaki, Koichi Akashi, Kiyoko Kato, Yoshinao Oda   +13 more
wiley   +1 more source

Bioactivity of anti-angiogenic ribozymes targeting Flt-1 and KDR mRNA [PDF]

, 1999
Tom J. Parry, Cynthia D. Cushman, Adalberto M. Gallegos, Apurva Agrawal, Mary Richardson, Lori Andrews, Lara Maloney, V. R. Mokier, Francine E. Wincott, P A Pavco   +9 more
openalex   +1 more source

A novel vascular endothelial growth factor, VEGF‐C, is a ligand for the Flt4 (VEGFR‐3) and KDR (VEGFR‐2) receptor tyrosine kinases.

EMBO Journal, 1996
V. Joukov, Katri Pajusola, A. Kaipainen, D. Chilov, I. Lahtinen, Eola Kukk, O. Saksela, N. Kalkkinen, K. Alitalo   +8 more
semanticscholar   +1 more source

Immunomodulatory Mechanism of Baiyaojian Decoction on Periodontitis: Network Pharmacology, Single‐Cell RNA Sequencing and Molecular Docking

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT Periodontitis is one of the most common oral inflammatory diseases. Baiyaojian decoction, known for its prominent immunomodulatory and anti‐inflammatory properties, shows significant potential in treating periodontitis, though its molecular mechanisms remain unknown. The active ingredients and therapeutic targets were determined by integrating
Bing‐jun Chen, Ming‐ming Li, Zhao‐yu Zheng, Wen‐qin Jin, Zhao Jin, Yu‐ling Zuo   +5 more
wiley   +1 more source

Mechanisms of pyrethroid resistance inHaematobia irritans (Muscidae) from Mato Grosso do Sul state, Brazil

Revista Brasileira de Parasitologia Veterinária
Horn fly resistance to pyrethroid insecticides occurs throughout Brazil, but knowledge about the involved mechanisms is still in an incipient stage. This survey was aimed to identify the mechanisms of horn fly resistance to cypermethrin in Mato Grosso do
Antonio Thadeu Medeiros Barros, Teresinha Tizu Sato Schumaker, Wilson Werner Koller, Guilherme Marcondes Klafke, Thais Aguiar de Albuquerque, Rodrigo Gonzalez   +5 more
doaj   +1 more source

Vascular Endothelial Growth Factor Receptor (VEGFR-2)/KDR Inhibitors: Medicinal Chemistry Perspective

Medicine in Drug Discovery, 2019
Siddharth J Modi, V. Kulkarni
semanticscholar   +1 more source

From farm to field: testing different biocrust cultivation approaches and application techniques in the Sonoran Desert

Restoration Ecology, Volume 34, Issue 2, February 2026.
Abstract Drylands are among the most degraded ecosystems globally and are difficult to restore due to limited water availability. Biocrusts are a key component of maintaining soil stability and function in these systems. Since biocrust salvage opportunities are limited, cultivating salvaged biocrusts is a promising method.
Helen I. Rowe, Anita Antoninka, Debbie Langenfeld, Jane Brady, Tiffany A. Sprague, Mary Fastiggi, Daniel R. Kollath, Marieke L. Ramsey, Bridget M. Barker   +8 more
wiley   +1 more source

Detection of 1014F kdr mutation in four major Anopheline malaria vectors in Indonesia [PDF]

, 2010
Din Syafruddin, Anggi P. N. Hidayati, Puji Budi Setia Asih, Penelope A. Phillips‐Howard, Supratman Sukowati, Neil F. Lobo   +5 more
openalex   +1 more source

Isoquercetin and Zafirlukast Cooperatively Suppress Tumor Growth and Thromboinflammatory Signaling in a Xenograft Model of Ovarian Cancer

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
Treatment using either the thiol isomerase inhibitor isoquercetin or zafirlukast lowers tissue factor levels, decreases VEGF, inhibits PD‐L1, and TMEM176B in a xenograft model of ovarian cancer. A combination of the two agents, at threefold lower concentrations than either drug, significantly enhanced the inhibition further, suggesting a dual action of
Justine A. Keovilay, Jason W. Hoskins, Jean‐Pierre Kinet, Thomas C. Lines, Daniel R. Kennedy   +4 more
wiley   +1 more source

The tyrosine kinase KDR is essential for the survival of HTLV-1-infected T cells by stabilizing the Tax oncoprotein

Nature Communications
Human T-cell leukemia virus type 1 (HTLV-1) infection is linked to the development of adult T-cell leukemia/lymphoma (ATLL) and the neuroinflammatory disease, HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The HTLV-1 Tax oncoprotein
Suchitra Mohanty, Sujit Suklabaidya, Alfonso Lavorgna, Takaharu Ueno, Jun-ichi Fujisawa, Nyater Ngouth, Steven Jacobson, Edward W. Harhaj   +7 more
doaj   +1 more source