Results 11 to 20 of about 53,382 (285)

Thienopyridine urea inhibitors of KDR kinase

Bioorganic & Medicinal Chemistry Letters, 2006
A series of substituted thienopyridine ureas was prepared and evaluated for enzymatic and cellular inhibition of KDR kinase activity. Several of these analogs, such as 2, are potent inhibitors of KDR (
H. Robin Heyman, Robin R. Frey, Peter F. Bousquet, George A. Cunha, Maria D. Moskey, Asma A. Ahmed, Niru B. Soni, Patrick A. Marcotte, Lori J. Pease, Keith B. Glaser, Melinda S. Yates, Jennifer J. Bouska, Daniel H. Albert, Candace Black‐Schaefer, Peter J. Dandliker, Kent D. Stewart, Paul Rafferty, Steven K. Davidsen, Michael R. Michaelides, Michael L. Curtin   +19 more
openalex   +3 more sources

KDR activation in astrocytic neoplasms [PDF]

Cancer, 1999
The development of new capillary networks appears to be necessary for the growth of solid tumors. Tumor angiogenesis is believed to be mediated by soluble factors released from tumor cells that then act on endothelial cells in a paracrine manner. Vascular endothelial growth factor (VEGF) is a prime regulator of normal and tumor angiogenesis as well as ...
R. S. Carroll, J. Zhang, L. Bello, M. B. Melnick, T. Maruyama, P. Mcl Black   +5 more
openaire   +4 more sources

Liver progenitor cell and KDR [PDF]

Cell Cycle, 2014
Liver disease affects hundreds of millions of patients worldwide. Liver transplantation is currently the only curable treatment for liver failure caused by cirrhosis, chronic hepatitis B or C, bile duct disease, genetic disease, autoimmune liver disease, primary liver cancer, alcoholic liver disease, or fatty liver disease.
Han, Songyan, Goldman, Orit, Gouon-Evans, Valerie   +2 more
openaire   +2 more sources

Isolation of Sponge Bacterial Symbionts from Kodingareng Keke Island-Makassar Indonesia Which is Potential as a Producer of Antimicrobial Compounds

Journal of Pure and Applied Microbiology, 2022
Sponge is an invertebrate animal in the Porifera phylum, which potentially produces bioactive compounds that are known as potential agents in producing antimicrobial compounds.
Herlina Rante, Gemini Alam, Usmar Usmar, Rhezky Awalia Anwar, Alimuddin Ali   +4 more
doaj   +1 more source

Serum bile acids as a prognostic biomarker in biliary atresia following Kasai portoenterostomy

Hepatology, EarlyView., 2022
Serum bile acid levels predict outcomes in patients with biliary atresia who achieve normalized bilirubin levels after Kasai portoenterostomy. Abstract Background and Aims In biliary atresia, serum bilirubin is commonly used to predict outcomes after Kasai portoenterostomy (KP).
Sanjiv Harpavat, Kieran Hawthorne, Kenneth D. R. Setchell, Monica Narvaez Rivas, Lisa Henn, Charlotte A. Beil, Saul J. Karpen, Vicky L. Ng, Estella M. Alonso, Jorge A. Bezerra, Stephen L. Guthery, Simon Horslen, Kathy M. Loomes, Patrick McKiernan, John C. Magee, Robert M. Merion, Jean P. Molleston, Philip Rosenthal, Richard J. Thompson, Kasper S. Wang, Ronald J. Sokol, Benjamin L. Shneider, for Childhood Liver Disease Research Network (ChiLDReN)   +22 more
wiley   +1 more source

A comparison of DNA sequencing and the hydrolysis probe analysis (TaqMan assay) for knockdown resistance (kdr) mutations in Anopheles gambiae from the Republic of the Congo

Malaria Journal, 2010
Background Knockdown resistance (kdr) caused by a single base pair mutation in the sodium channel gene is strongly associated with pyrethroid insecticide resistance in Anopheles gambiae in West-Central Africa.
Coetzee Maureen, Spillings Belinda L, Choi Kwang, Hunt Richard H, Koekemoer Lizette L   +4 more
doaj   +1 more source

Distribution and pyrethroid resistance status of Aedes aegypti and Aedes albopictus populations and possible phylogenetic reasons for the recent invasion of Aedes aegypti in Nepal

Parasites & Vectors, 2020
Background When the first systematic list of mosquitoes in Nepal was reported in 1990, there was no description of Aedes aegypti (L.), while Aedes albopictus (Skuse) has been included in the Stegomyia subgroup since the 1950s.
Hitoshi Kawada, Kyoko Futami, Yukiko Higa, Ganesh Rai, Takashi Suzuki, Shiba Kumar Rai   +5 more
doaj   +1 more source

First evidence of high knockdown resistance frequency in anopheles arabiensis (diptera: Culicidae) from Ethiopia [PDF]

, 2010
The status of knockdown resistance (kdr) mutation was investigated in the major malaria vector Anopheles arabiensis Patton (Diptera: Culicidae) from Ethiopia.
Gebre, Delenasaw Yewhalaw, Van Bortel, Wim, Denis, Leen, Coosemans, Marc, Duchateau, Luc, Speybroeck, Niko   +5 more
core   +1 more source

Molecular identification of allelic genotypes of pyrethroid-insecticide resistance in housefly, Iraq [PDF]

Iraqi Journal of Veterinary Sciences, 2019
According to global-wide presence of insecticides resistance to pyrethroids, the current study identified the purpose to detect the allelic genotypes regarding this issue in house flies in Iraq.
Monyer Abdulameir Abd Alfatlawi, Mansour Ali, Hassan Naser   +2 more
doaj   +1 more source

Occurrence of the Leucine-to-Phenylalanine knockdown Resistance (kdr) Mutation in Anopheles Arabiensis Populations in Tanzania, Detected by a Simplified High-Throughput SSOP-ELISA Method. [PDF]

, 2006
Molecular markers of insecticide resistance can provide sensitive indicators of resistance development in malaria vector populations. Monitoring of insecticide resistance in vector populations is an important component of current malaria control ...
Alifrangis, Michael, Drakeley, Chris, Kulkarni, Manisha A, Kweka, Eliningaya, Lyimo, Issa, Magesa, Stephen, Malima, Robert, Matowo, Johnson, Mosha, Frank W, Peter, Justin, Rau, Manfred E, Rowland, Mark, Salanti, Ali   +12 more
core   +3 more sources