Results 111 to 120 of about 544,512 (208)

Multi‐Mechanistic Effects of Xylopia aethiopica Fruits on Uterine Fibroids: Insights From In Vivo and In Silico Evidence

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Xylopia aethiopica fruit extract modulates progesterone and estradiol levels in monosodium glutamate‐induced uterine fibroid models. In silico analyses reveal strong binding of its phytochemicals to progesterone, estrogen, VEGFR2, and TGF‐β receptors, indicating multi‐target anti‐fibroid actions involving hormonal regulation, anti‐angiogenesis, and ...
Adedokun Oluwasegun, Ume Ogochukwu, Akinsola Olubiyi, Agada Emmanuel, Adebiyi Omowumi, Idogho Eseoghena, Adedokun Folake, Adekunle Temilade   +7 more
wiley   +1 more source

Effects of Drug Resistance on the Global Spread of Malaria: A Systematic Literature Review

Health Science Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background and Aims Malaria remains a major health crisis in tropical regions, with Sub‐Saharan Africa bearing the heaviest burden. While insecticide‐treated nets and artemisinin‐based combination therapies (ACTs) have reduced cases, emerging parasite resistance to artemisinin threatens these gains. This review synthesizes evidence on how drug
Ashenafi Woldemichael Woime
wiley   +1 more source

Resistance to pyrethroid and organophosphate insecticides, and the geographical distribution and polymorphisms of target-site mutations in voltage-gated sodium channel and acetylcholinesterase 1 genes in Anopheles sinensis populations in Shanghai, China

Parasites & Vectors, 2019
Background In the final phase of China’s national programme to eliminate malaria by 2020, it is vitally important to monitor the resistance of malaria vectors for developing effective vector control strategies.
Yuan Fang, Wen-Qi Shi, Jia-Tong Wu, Yuan-Yuan Li, Jing-Bo Xue, Yi Zhang   +5 more
doaj   +1 more source

New perspectives on VEGF signalling in Alzheimer's disease

Brain Pathology, Volume 36, Issue 5, September 2026.
Emery et al. bring together findings from recent multi‐omic studies, including single‐cell mRNA analysis of human post‐mortem brain tissue, and proteomic analysis of matched CSF and blood samples in large clinical studies. The authors present evidence of the involvement of altered VEGF signalling in vascular and immune dysfunction and neurodegeneration
Cherelle E. G. Emery, Seth Love, J. Scott Miners   +2 more
wiley   +1 more source

Evidence for at least two independent origins for the 1534C kdr mutation in Aedes aegypti.

, 2020
Bars show the haplotype frequencies of IIS6 and IIIS6 NaV segments found in five localities that are fixed for 3s6-01 haplotype (A). The IIS6 haplotypes from Clades A or B (see Fig 2) are represented as purple and green lines, respectively. Two different
Ademir Jesus Martins (7425491), Luciano Veiga Cosme (8721609), Jeffrey Robert Powell (8721612), Andrea Gloria-Soria (606808), Adalgisa Caccone (36654)   +4 more
core   +1 more source

Knockdown resistance (kdr)-like mutations in the voltage-gated sodium channel of a malaria vector Anopheles stephensi and PCR assays for their detection

Malaria Journal, 2011
Background Knockdown resistance (kdr) in insects, resulting from mutation(s) in the voltage-gated sodium channel (vgsc) gene is one of the mechanisms of resistance against DDT and pyrethroid-group of insecticides.
Agrawal Om P, Lather Manila, Dykes Cherry L, Singh Om P, Adak Tridibes   +4 more
doaj   +1 more source

Comparative Response of Canine and Human Osteosarcoma Tumour Cell Lines to Molecularly Targeted Anticancer Agents at Clinically Relevant Exposures With Analysis of Genomic Biomarkers

Veterinary and Comparative Oncology, Volume 24, Issue 3, Page 532-544, September 2026.
ABSTRACT Osteosarcoma (OSA) is a primary bone tumour occurring in children but is also prevalent in large breed dogs. Canine OSA (cOSA) has long been viewed as analogous to human OSA (hOSA) with cOSA serving as a surrogate for development of therapeutic approaches to treat the rarer human form.
Daniel L. Gustafson, Kala A. Early, Maritza A. Morales, Klaudia A. Poplawski, Sunetra Das, Dawn L. Duval   +5 more
wiley   +1 more source

Combining indoor residual spraying with chlorfenapyr and long-lasting insecticidal bed nets for improved control of pyrethroid-resistant Anopheles gambiae: an experimental hut trial in Benin. [PDF]

, 2011
BACKGROUND: Neither indoor residual spraying (IRS) nor long-lasting insecticidal nets (LLINs) are able to fully interrupt transmission in holoendemic Africa as single interventions.
Mark Rowland, N'Guessan Raphael, Estelle Vigninou, Boko, Pelagie, Asidi, A, Akogbeto Martin, Abibatou Odjo, Boko Pelagie, Alex Asidi, Akogbeto, Martin, Rowland, M, Rowland Mark, N'Guessan, Raphael, Vigninou, E, Vigninou Estelle, Vigninou, Estelle, Rowland, Mark, Akogbeto, M, Ngufor Corine, Odjo Abibatou, N'guessan, R, Ngufor, C, Odjo, A, Martin Akogbeto, Odjo, Abibatou, Pelagie Boko, Asidi, Alex, Ngufor, Corine, Raphael N'Guessan, Boko, P, Corine Ngufor, Asidi Alex   +31 more
core   +1 more source

Genotypes of Aedes aegypti populations from Douala, Cameroon considering V1016I, V410L kdr and F1534C mutation in the VGSC.

, 2022
Genotypes of Aedes aegypti populations from Douala, Cameroon considering V1016I, V410L kdr and F1534C mutation in the VGSC.
Christophe R. Keumeni (14253353), Charles Wondji (3419594), Armel N. Tedjou (6475892), Basile Kamgang (220022), Theodel A. Wilson-Bahun (8201910), Aurelie P. Yougang (8991353), Flobert Njiokou (208646)   +6 more
core   +1 more source

A simplified high-throughput method for pyrethroid knock-down resistance (kdr) detection in Anopheles gambiae

Malaria Journal, 2005
Background A single base pair mutation in the sodium channel confers knock-down resistance to pyrethroids in many insect species. Its occurrence in Anopheles mosquitoes may have important implications for malaria vector control especially considering the
Walker Edward D, Black William C, Randle Nadine P, McCall P J, Ranson Hilary, Lynd Amy, Donnelly Martin J   +6 more
doaj   +1 more source