Results 61 to 70 of about 9,255 (204)

Low prevalence of Plasmodium and absence of malaria transmission in Conakry, Guinea : prospects for elimination [PDF]

, 2016
Over the past 15 years, mortality and morbidity due to malaria have been reduced substantially in sub-Saharan Africa and local elimination has been achieved in some settings.
Koudou, Benjamin, de Souza, Dziedzom K., Bockarie, Moses J., Bockarie, Moses, Kouassi, Bernard L., Utzinger, Jürg, Diakité, Lamia, Sagno, Arsène, Koudou, Benjamin G., Chammartin, Frédérique, Goepogui, Andre, Djameh, Georgina I., Vounatsou, Penelope, Balde, Siradiou M.   +13 more
core   +1 more source

Frequency of kdr genotypes in Aedes aegypti mosquito from Douala, Cameroon considering F1534C, V1016I and V410L kdr mutation in the VGSC.

, 2022
Frequency of kdr genotypes in Aedes aegypti mosquito from Douala, Cameroon considering F1534C, V1016I and V410L kdr mutation in the VGSC.
Christophe R. Keumeni (14253353), Charles Wondji (3419594), Armel N. Tedjou (6475892), Basile Kamgang (220022), Theodel A. Wilson-Bahun (8201910), Aurelie P. Yougang (8991353), Flobert Njiokou (208646)   +6 more
core   +1 more source

Kdr 1014L mutation frequency in tested wild-caught mosquitoes.

, 2018
Kdr 1014L mutation frequency in tested wild-caught mosquitoes.
Abel Souro Millogo (5728757), Brian Lovett (5022596), Roch K. Dabiré (297382), Abdoulaye Diabate (3277302), Issiaka Saré (5728760), Antoine Sanon (231033), Raymond J. St. Leger (141945), Koama Bayili (5728754), Etienne Bilgo (3826324)   +8 more
core   +1 more source

Somatic p.T771R KDR (VEGFR2) Mutation Arising in a Sporadic Angioma During Ramucirumab Therapy [PDF]

JAMA Dermatology, 2015
Inhibition of angiogenesis is an effective anticancer strategy because neoplasms require a rich blood supply. Ramucirumab, approved by the US Food and Drug Administration in 2014 to treat gastric adenocarcinomas and non-small cell lung carcinomas, targets vascular endothelial growth factor 2 (VEGFR2).
Young H, Lim, Ian D, Odell, Christine J, Ko, Keith A, Choate   +3 more
openaire   +2 more sources

Molecular ecology of pyrethroid knockdown resistance in Culex pipiens pallens mosquitoes. [PDF]

PLoS ONE, 2010
Pyrethroid insecticides have been extensively used in China and worldwide for public health pest control. Accurate resistance monitoring is essential to guide the rational use of insecticides and resistance management.
Lin Chen, Daibin Zhong, Donghui Zhang, Linna Shi, Guofa Zhou, Maoqing Gong, Huayun Zhou, Yan Sun, Lei Ma, Ji He, Shanchao Hong, Dan Zhou, Chunrong Xiong, Chen Chen, Ping Zou, Changliang Zhu, Guiyun Yan   +16 more
doaj   +1 more source

Sensitivity of the Drosophila para sodium channel to DDT is not lowered by the super-kdr mutation M918T on the IIS4–S5 linker that profoundly reduces sensitivity to permethrin and deltamethrin

, 2005
DDT inhibits Na channel inactivation and deactivation, promotes Na channel activation and reduces the resting potential of Xenopus oocytes expressing the Drosophila para Na channel.
Khambay, B.P.S., Williamson, M.S., Khambay, B. P. S., Usherwood, P.N.R., Vais, H., Usherwood, P. N. R., Davies, T. G. E., Davies, T.G.E., Williamson, M. S.   +8 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal, Milan Patra, Rianita Mondal, Shubhasis Haldar   +3 more
wiley   +1 more source

Insecticide Resistance Profile of Mosquitoes: A Study of a Residential and Industrial Breeding Sites in Kano Metropolis, Nigeria

Environmental Health Insights, 2020
Monitoring and understanding the trend and dynamics of insecticide resistance is very key to devising efficient control strategies. This study was carried out to characterize the mosquito population, its insecticide resistance profile, and the ...
Chimaobi J Ononamadu, John T Datit, Abdullahi A Imam   +2 more
doaj   +1 more source

Genetic structure of Aedes albopictus (Diptera: Culicidae) populations in China and relationship with the knockdown resistance mutations

Infectious Diseases of Poverty, 2023
Background Mosquito control is needed to prevent dengue fever, which is mainly spread by Aedes albopictus in China. Application of insecticides is one of the main mosquito control methods; however, this approach can fail due to the knockdown resistance ...
Wenqi Shan, Hao Yuan, Hanming Chen, Haowei Dong, Qiuming Zhou, Feng Tao, Jie Bai, Huiying Chen, Yajun Ma, Heng Peng   +9 more
doaj   +1 more source