Results 61 to 70 of about 544,512 (208)

Insecticide resistance in the malarial mosquito Anopheles arabiensis and association with the kdr mutation [PDF]

Medical and Veterinary Entomology, 2007
Abstract A colony of Anopheles arabiensis Patton (Diptera: Culicidae) from the Sennar region of Sudan was selected for resistance to dichlorodiphenyltrichloroethane (DDT).
T S, Matambo, H, Abdalla, B D, Brooke, L L, Koekemoer, A, Mnzava, R H, Hunt, M, Coetzee   +6 more
openaire   +2 more sources

An electrophysiological investigation of the susceptible (Cooper) and resistant (kdr; super-kdr ) strains of the adult housefly, Musca domestica L.

, 1988
Sensory fibres in the isolated metathoracic leg of houseflies were used as a neurophysiological assay to investigate nerve insensitivity factors in knockdown-resistant strains (kdr, super-kdr) against DDT, the pyrethroids deltamethrin and RU15525, and ...
Gibson, A. J., Sawicki, R. M., Ross, H. F., Osborne, M. P.   +3 more
core   +1 more source

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

Molecular ecology of pyrethroid knockdown resistance in Culex pipiens pallens mosquitoes. [PDF]

PLoS ONE, 2010
Pyrethroid insecticides have been extensively used in China and worldwide for public health pest control. Accurate resistance monitoring is essential to guide the rational use of insecticides and resistance management.
Lin Chen, Daibin Zhong, Donghui Zhang, Linna Shi, Guofa Zhou, Maoqing Gong, Huayun Zhou, Yan Sun, Lei Ma, Ji He, Shanchao Hong, Dan Zhou, Chunrong Xiong, Chen Chen, Ping Zou, Changliang Zhu, Guiyun Yan   +16 more
doaj   +1 more source

GM‐CSF Promotes Neutrophil PD‐L1 Expression Through the VEGFR‐2/STAT6/CSF2 Signaling Axis in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
VEGFR‐2 signaling in OSCC activates Src–STAT6‐dependent CSF2 transcription, driving tumor‐derived GM‐CSF secretion. GM‐CSF programs neutrophils to express PD‐L1 through STAT5–mTOR/S6K signaling, suppressing cytotoxic CD8+ T cells. This pathway reveals a tumor–neutrophil immune checkpoint circuit that limits anti‐PD‐1 responsiveness in OSCC.
Fangxing Zhu, Yuanhe You, Yiyi Zhang, Yibin Dai, Xinyu Zhou, Yong Fu, Xi Lu, Yingying Huang, Zhihang Zhou, Ronghui Xia, Wutong Ju, Zhaoqi Yuan, Laiping Zhong, Tongchao Zhao   +13 more
wiley   +1 more source

Kdr 1014L mutation frequency in tested wild-caught mosquitoes.

, 2018
Kdr 1014L mutation frequency in tested wild-caught mosquitoes.
Abel Souro Millogo (5728757), Brian Lovett (5022596), Roch K. Dabiré (297382), Abdoulaye Diabate (3277302), Issiaka Saré (5728760), Antoine Sanon (231033), Raymond J. St. Leger (141945), Koama Bayili (5728754), Etienne Bilgo (3826324)   +8 more
core   +1 more source

Frequency of kdr genotypes in Aedes aegypti mosquito from Douala, Cameroon considering F1534C, V1016I and V410L kdr mutation in the VGSC.

, 2022
Frequency of kdr genotypes in Aedes aegypti mosquito from Douala, Cameroon considering F1534C, V1016I and V410L kdr mutation in the VGSC.
Christophe R. Keumeni (14253353), Charles Wondji (3419594), Armel N. Tedjou (6475892), Basile Kamgang (220022), Theodel A. Wilson-Bahun (8201910), Aurelie P. Yougang (8991353), Flobert Njiokou (208646)   +6 more
core   +1 more source

Somatic p.T771R KDR (VEGFR2) Mutation Arising in a Sporadic Angioma During Ramucirumab Therapy [PDF]

JAMA Dermatology, 2015
Inhibition of angiogenesis is an effective anticancer strategy because neoplasms require a rich blood supply. Ramucirumab, approved by the US Food and Drug Administration in 2014 to treat gastric adenocarcinomas and non-small cell lung carcinomas, targets vascular endothelial growth factor 2 (VEGFR2).
Young H, Lim, Ian D, Odell, Christine J, Ko, Keith A, Choate   +3 more
openaire   +2 more sources

Experimental hut evaluation of bednets treated with an organophosphate (chlorpyrifos-methyl) or a pyrethroid (lambdacyhalothrin) alone and in combination against insecticide-resistant Anopheles gambiae and Culex quinquefasciatus mosquitoes. [PDF]

, 2005
BACKGROUND: Pyrethroid resistant mosquitoes are becoming increasingly common in parts of Africa. It is important to identify alternative insecticides which, if necessary, could be used to replace or supplement the pyrethroids for use on treated nets ...
Chandre Fabrice, Alphonsine A Koffi, Darriet, Frédéric, Asidi, A.N., Zaim, M., Zaim, Morteza, Koffi, A.A., Frédéric Darriet, Asidi, AN, N'Guessan, R., Curtis Christopher F, Hougard, Jean-Marc, Asidi Alex N, Corbel, V, Morteza Zaim, Chandre, F, Asidi, Alex N, Hougard, JM, Rowland, Mark W, Hougard Jean-Marc, N'Guessan, Raphael, Vincent Corbel, N' Guessan Raphael, Chandre, Fabrice, Curtis, C.F., Curtis, Christopher F, Mark W Rowland, Christopher F Curtis, Corbel Vincent, Darriet Frédéric, Koffi, Alphonsine A, Koffi, AA, Rowland, MW, Rowland Mark W, Fabrice Chandre, Rowland, M.W., Raphael N' Guessan, N'Guessan, R, Jean-Marc Hougard, Zaim Morteza, Darriet, F, Curtis, CF, Alex N Asidi, Corbel, Vincent, Zaim, M, Koffi Alphonsine A   +45 more
core   +1 more source

Monitoring pharmacodynamic and molecular drug targets in liquid biopsy: Exploratory study in liver cancer with modelling of EGFR Receptor engagement

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Liquid biopsy is minimally invasive (compared with tissue biopsy) and has previously been used to generate systems data regarding drug elimination via hepatic enzymes and transporters. This study extends quantitative assessment of systems parameters in liquid biopsy to pharmacodynamic (PD) and disease markers relevant to cancer development
Zubida M. Al‐Majdoub, Armin Sepp, Amin Rostami‐Hodjegan, Brahim Achour   +3 more
wiley   +1 more source