Results 91 to 100 of about 18,369 (261)

Keloid Patient Plasma-Derived Exosomal hsa_circ_0020792 Promotes Normal Skin Fibroblasts Proliferation, Migration, and Fibrogenesis via Modulating miR-193a-5p and Activating TGF-β1/Smad2/3 Signaling

Drug Design, Development and Therapy, 2022
Huan Hu,* Guangyu Mao,* Jianghong Zheng, Feng Guo Department of Plastic Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, People’s Republic of China*These authors ...
Hu H, Mao G, Zheng J, Guo F
doaj  

A Sequential Treatment of Keloids: Multiple‐Hole Punch Excision Combined With Superficial Radiation and Drug [PDF]

J Cosmet Dermatol
ABSTRACT Background Dense and multiple keloids present significant therapeutic challenges due to their stubborn nature and high recurrence rates. Although various treatment options exist, optimizing current approaches and integrating them into a rational, systematic regimen for keloid management remains a difficult clinical problem.
Gong Z, Jing W, Zhang Z, Rao W, Lei W, Yang J, Ai Y, Tao X.   +7 more
europepmc   +2 more sources

WTAP‐mediated m6A RNA methylation promotes diabetic foot ulcer healing under negative pressure wound therapy

Journal of Diabetes Investigation, EarlyView.
NPWT significantly increases the suppressed WTAP and m6A levels in DFU patients, correlating directly with better 4‐week healing outcomes. In vitro, negative pressure reverses high‐glucose‐induced WTAP downregulation, restoring the cell proliferation and migration necessary for wound repair.
Yutong Li, Wenhua Chen, Jianhao Lu, Xiaoyue Lin, Ying Tang, Jiaxu Li, Mingwei Chen   +6 more
wiley   +1 more source

Dysregulation of DPP4-CXCL12 Balance by TGF-β1/SMAD Pathway Promotes CXCR4+ Inflammatory Cell Infiltration in Keloid Scars

Journal of Inflammation Research, 2021
ZongAn Chen,1,* Zhen Gao,1,* LingLing Xia,1 XiaoQing Wang,2,* LiMing Lu,3,* XiaoLi Wu1,* 1Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai ...
Chen Z, Gao Z, Xia L, Wang X, Lu L, Wu X
doaj  

Measuring success in HS treatment from the physician's and the patient's perspective

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Integrated clinician (HiSCR, IHS4, IHS4‐55, HS‐IGA) and patient (HiSQOL, DLQI) scores, combined with imaging‐based fibrosis and inflammation assessment, redefine treatment success in hidradenitis suppurativa by aligning treat‐to‐target strategies with both inflammatory control and irreversible structural damage.
Georgios Nikolakis, Monika Arenbergerova, Zeljko Mijuskovic, Baoxi Wang, Christos C. Zouboulis   +4 more
wiley   +1 more source

Ubiquitin-related Protein IFNGR1 as Causal Factor and Drug Target for Keloids: A Mendelian Randomization Analysis

Plastic and Reconstructive Surgery, Global Open
Background:. Keloids, benign skin tumors due to connective tissue overgrowth, can be exacerbated by ubiquitin-proteasome system abnormalities through uncontrolled inflammation.
Yeltai Nurzat, PhD, Zhenhe Guo, PhD, Julong Hu, PhD, Zaihuan Lin, MD, Qi Zhang, PhD, Gang Liang, MD, Hang Ji, PhD, MD, Xiaowen Zhang, PhD, MD   +7 more
doaj   +1 more source

Mortalin deficiency suppresses fibrosis and induces apoptosis in keloid spheroids

Scientific Reports, 2017
Mortalin (Mot) is a mitochondrial chaperone of the heat shock protein 70 family and it’s pro-proliferative and anti-apoptosis functions could be associated with keloid pathogenesis, and blocking of mortalin and its interaction with p53 might be a ...
Won Jai Lee, Hyo Min Ahn, Youjin Na, Renu Wadhwa, JinWoo Hong, Chae-Ok Yun   +5 more
doaj   +1 more source

A Toe Keloid after Syndactyly Release Treated with Surgical Excision and Intralesional Steroid Injection

Plastic and Reconstructive Surgery, Global Open, 2014
Summary: A keloid is a benign fibroproliferative disease of unknown etiology. Although it is common among Asians, the development of keloid on the foot is rare.
Satoko Yamawaki, MD, Motoko Naitoh, MD, PhD, Toshihiro Ishiko, MD, PhD, Rino Aya, MD, Yasuhiro Katayama, MD, Shigehiko Suzuki, MD, PhD   +5 more
doaj   +1 more source

Keloid

, 1997
Before injecting the keloid with the corticosteroid, I recommend injecting local anesthetic into the underlying fat, and waiting about five minutes for the anesthetic to take effect.
Bezzant, John L.
core  

Consensus on energy‐based devices for keloids and hypertrophic scars: A Latin American Delphi study

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Latin American Delphi consensus supports a sequential, multimodal approach to keloids and hypertrophic scars: vascular devices for early/inflammatory lesions; intralesional triamcinolone + 5‐fluorouracil and other injectable drugs for active scars; fractional lasers for texture; and pigment‐targeting therapies for dyschromia, prioritizing safety in ...
Gisele Viana de Oliveira, Patricia Apt Druck, Alvaro Andres Luque Acevedo, Doris Hexsel, Gabriel Teixeira Gontijo, Gabriel Huerta Rivera, Luis Leobardo Velázquez‐Arenas, Flávia Alvim Sant Anna Addor, Fátima Agüero Zaputovich, Hector Leal‐Silva, Sebastian Leal‐Delgado, Carlos Echevarría Escribens, Kleber Danilo Ollague Murillo, Susana Misticone, Leandra D'orsi Metsavaht, Johnny de la Riva, Daniel Ricardo Galimberti, Silvia Karina Kaminsky Jedwab, Hector Ricardo Galván Garcia, Marcia Ramos‐e‐Silva, Mariana Rocha Andrade, Eugenio Reis‐Filho, Marcio Roberto Silva, George Kroumpouzos, Daniela Guzmán‐Sánchez   +24 more
wiley   +1 more source