Results 61 to 70 of about 40,839 (332)

Fibroblast Dynamics in Keloid Pathogenesis: Unraveling Cellular Crosstalk and Novel Therapeutic Targets [PDF]

Dermatology Research and Practice
Keloid scars represent a complex fibroproliferative disorder characterized by abnormal wound healing and excessive collagen deposition. Central to keloid pathogenesis are dynamic fibroblast populations that undergo extensive phenotypic transitions, including heterogeneous subpopulation differentiation, enhanced migration, myofibroblast ...
Alkouz Z, Al Suwait A, Zhang L, Alhejairi R, Gahimbare F, Qalalwa M, Yang B.   +6 more
europepmc   +2 more sources

Defining a Unique Gene Expression Profile in Mature and Developing Keloids

JID Innovations, 2023
Keloids are benign, fibroproliferative dermal tumors that typically form owing to abnormal wound healing. The current standard of care is generally ineffective and does not prevent recurrence.
Yuan O. Zhu, Scott MacDonnell, Theodore Kaplan, Chien Liu, Yasmeen Ali, Stephanie M. Rangel, Matthew F. Wipperman, Madeleine Belback, Daphne S. Sun, Ziyou Ren, Xiaolong Alan Zhou, Gabor Halasz, Lori Morton, Roopal V. Kundu   +13 more
doaj   +1 more source

Control of the skin scarring response [PDF]

, 2009
There comes a time when the understanding of the cutaneous healing process becomes essential due to the need for a precocious tissue repair to reduce the physical, social, and psychological morbidity.
Ferreira, Lydia Masako, Furtado, Fabianne, Gragnani, Alfredo, Hochman, Bernardo   +3 more
core   +3 more sources

RNA Sequencing Keloid Transcriptome Associates Keloids With Th2, Th1, Th17/Th22, and JAK3-Skewing

Frontiers in Immunology, 2020
Keloids are disfiguring, fibroproliferative growths and their pathogenesis remains unclear, inhibiting therapeutic development. Available treatment options have limited efficacy and harbor safety concerns.
Jianni Wu, Ester del Duca, Mike Espino, A. Gontzes, I. Cueto, Ning Zhang, Y. Estrada, A. Pavel, J. Krueger, E. Guttman‐Yassky   +9 more
semanticscholar   +1 more source

Therapeutic Strategies by Regulating Interleukin Family to Suppress Inflammation in Hypertrophic Scar and Keloid

Frontiers in Pharmacology, 2021
Hypertrophic scar (HS) and keloid are fibroproliferative disorders (FPDs) of the skin due to aberrant wound healing, which cause disfigured appearance, discomfort, dysfunction, psychological stress, and patient frustration.
Dan Zhang, Bolotnova Li, MuXin Zhao
semanticscholar   +1 more source

Dasatinib Attenuates Fibrosis in Keloids by Decreasing Senescent Cell Burden

Acta Dermato-Venereologica, 2023
Keloids are skin tumours caused by aberrant growth of dermal fibroblasts. Cellular senescence contributes to aging and various pathological conditions, including cancer, atherosclerosis, and fibrotic diseases.
Claudia C. Darmawan, Keunyoung Hur, Novi Kusumaningrum, Jin Ho Chung, Si-Hyung Lee, Je-Ho Mun   +5 more
doaj   +1 more source

Different therapeutic modalities in a patient with multiple spontaneously developed keloids: a case report [PDF]

, 2006
Keloids are benign tumors that usually develop as an excessive healing response to injury. They remain a challenging therapeutic problem to this day. Numerous treatment approaches are available, yet therapeutic results are often not satisfactory.
Bukvić-Mokos, Zrinka, Lipozenčić, Jasna, Marinović, Branka   +2 more
core  

Mutations in MAP3K7 that Alter the Activity of the TAK1 Signaling Complex Cause Frontometaphyseal Dysplasia. [PDF]

, 2016
Frontometaphyseal dysplasia (FMD) is a progressive sclerosing skeletal dysplasia affecting the long bones and skull. The cause of FMD in some individuals is gain-of-function mutations in FLNA, although how these mutations result in a hyperostotic ...
Addor, M.C., Adès, L.C., Bertola, D., Bohring, A., Brown, M.A., Carter, E., Cho, T.J., Daniel, P.B., Duba, H.C., Duncan, E.L., Fletcher, E., Hennekam, R.C., Jenkins, Z.A., Kim, C.A., Krakow, D., Leo, P., Markie, D.M., McInerney-Leo, A., Morava, E., Morgan, T., Neuhann, T., Robertson, S.P., Strom, T.M., Superti-Furga, A., Sutherland-Smith, A.J., Veenstra-Knol, I., Wade, E.M., Wieczorek, D., Wilkie, A.O., Wilson, L.C.   +29 more
core   +3 more sources

Single-Cell Sequencing Analysis and Weighted Co-Expression Network Analysis Based on Public Databases Identified That TNC Is a Novel Biomarker for Keloid

Frontiers in Immunology, 2021
Background The pathophysiology of keloid formation is not yet understood, so the identification of biomarkers for kelod can be one step towards designing new targeting therapies which will improve outcomes for patients with keloids or at risk of ...
Jiaheng Xie, Liang Chen, Yuan Cao, Dan Wu, Wenwen Xiong, Kai Zhang, Jingping Shi, Ming Wang   +7 more
semanticscholar   +1 more source

Non‐RASopathy Genetic Syndromes Identified as the Molecular Cause of Disease in Patients Previously Diagnosed With Noonan Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Noonan Syndrome (NS) is a clinically and genetically heterogeneous condition characterized by typical facial dysmorphisms, short stature, congenital heart defects, and developmental delays. While variants in genes such as PTPN11, SOS1, and RAF1 account for most genetically confirmed cases, diagnosis is challenging due to phenotypic overlap ...
Gabriela Jeesoo Kim, Alexsandra Christianne Malaquias, Debora Romeo Bertola, Raissa Carneiro Rezende, Laurana De Polli Cellin, Lucas Vieira Lacerda Pires, Ana Maria Santillan‐Vasconez, Antônio Marcondes Lerario, Renata da Cunha Scalco, Alexander Augusto de Lima Jorge   +9 more
wiley   +1 more source