Results 61 to 70 of about 29,071 (276)

IL-17 Induces Autophagy Dysfunction to Promote Inflammatory Cell Death and Fibrosis in Keloid Fibroblasts via the STAT3 and HIF-1α Dependent Signaling Pathways

open access: yesFrontiers in Immunology, 2022
Keloid is an abnormal fibrotic disease after cutaneous injury characterized by exaggerated scar tissue formation, which often extends beyond the boundaries of the original wound.
Seon-Yeong Lee   +10 more
doaj   +1 more source

Non‐RASopathy Genetic Syndromes Identified as the Molecular Cause of Disease in Patients Previously Diagnosed With Noonan Syndrome

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Noonan Syndrome (NS) is a clinically and genetically heterogeneous condition characterized by typical facial dysmorphisms, short stature, congenital heart defects, and developmental delays. While variants in genes such as PTPN11, SOS1, and RAF1 account for most genetically confirmed cases, diagnosis is challenging due to phenotypic overlap ...
Gabriela Jeesoo Kim   +9 more
wiley   +1 more source

Impact of abnormal cesarean section scar formation on quality of life and postpartum depression: A cross‐sectional study in Japan

open access: yesInternational Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To determine the prevalence of abnormal scar formation after cesarean section and evaluate its effects on quality of life (QoL) and postpartum depression risk. Methods A nationwide cross‐sectional study of 991 women aged 18–45 years at 6–18 months post‐cesarean section was conducted in Japan. Participants completed validated measures
Yosuke Sugita   +10 more
wiley   +1 more source

3D keloid spheroid model: Development and application for personalized drug response prediction

open access: yesCommunications Biology
Research on keloid is limited by the lack of proper in vitro and animal model reflecting in vivo status. Based on heterogeneity of keloid and important role of endothelial cells in its pathogenesis, a novel 3D in vitro keloid spheroid prepared with ...
YoungHwan Choi   +9 more
doaj   +1 more source

Heteroenxerto de quelóide na bolsa jugal do hamster (Mesocricetus auratus) [PDF]

open access: yes, 2005
PURPOSE: To study the integration of keloid heterograft in hamster (Mesocricetus auratus) cheek pouch. METHODS: The sample is formed by 18 male hamsters, heterogenic ones, aged between 10 and 14 weeks.
Ferreira, Lydia Masako   +3 more
core   +4 more sources

Plaque‐Like Dermatofibroma: A Case Report and a Review of the Literature With a Focus on Dermoscopy

open access: yesJEADV Clinical Practice, EarlyView.
ABSTRACT Plaque‐like dermatofibroma (PLDF) is a rare clinical variant of dermatofibroma (DF), characterised by flat, infiltrative lesions, often larger than 50 mm in diameter and located on the trunk or lower extremities. A 44‐year‐old male presented to our clinic with a 20 cm brownish plaque with peripheral satellite lesions on the right antecubital ...
Francesco Cavallo   +7 more
wiley   +1 more source

Construction of a HOXA11-AS-Interacted Network in Keloid Fibroblasts Using Integrated Bioinformatic Analysis and in Vitro Validation

open access: yesFrontiers in Genetics, 2022
Background: Expression of the long noncoding RNA (lncRNA) HOXA11-AS significantly increased in keloids by unclarified molecular regulation mechanisms.Methods: Using successfully primary cultured keloid-derived fibroblasts from central region of chronic ...
Qiang Wang, Wei Wang, Xiao-jie Sun
doaj   +1 more source

Observation‐Only Management of Cervicofacial Nontuberculous Mycobacterial Lymphadenitis in Children

open access: yesThe Laryngoscope, EarlyView.
This is a retrospective study of immunocompetent children with nontuberculous mycobacterial cervicofacial lymphadenitis who were managed by observation. Kaplan–Meier‐estimated cumulative resolution was 82.8% by 12 months. Observation may be a safe, effective alternative to surgical excision for selected patients.
Cheyenne Roohani   +3 more
wiley   +1 more source

Sustained‐Release Sitagliptin Microneedles for Scar Prevention via Fibroblast‐to‐Adipocyte Conversion

open access: yesSmall Science, EarlyView.
The authors propose a novel use for the conventional hypoglycemic drug, dipeptidyl peptidase IV (DPP4+) inhibitor sitagliptin. Sitagliptin prevents scar formation during wound healing through fibroblast‐to‐adipocyte conversion at least by preventing DPP4‐mediated truncation of IGF‐1.
Ju‐Lei Zhang   +14 more
wiley   +1 more source

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