IFNγ regulates ferroptosis in KFs by inhibiting the expression of SPOCD1 through DNMT3A
Cell Death DiscoveryKeloid is benign skin tumor, and their curing is relatively difficult due to the unclear mechanism of formation. Inducing ferroptosis of keloid fibroblasts (KFs) may become a new method for treating keloid.
Xiuxia Wang +7 more
doaj +1 more source
A Holistic Approach to Unravel Keloid Pathogenesis and Optimize Therapeutic Outcomes
BiomedicinesAlthough tremendous progress has been made over the past decades in elucidating the mechanisms of keloid formation and developing therapeutic interventions, keloid remains challenging to cure and prone to recurrence.
Zhendong Cao, Wei Liu
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Ferrostatin-1 inhibits fibroblast fibrosis in keloid by inhibiting ferroptosis [PDF]
PeerJBackground Keloid is a chronic proliferative fibrotic disease caused by abnormal fibroblasts proliferation and excessive extracellular matrix (ECM) production.
Liu Yang, Xiuli Li, Yanli Wang
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Defining a Unique Gene Expression Profile in Mature and Developing Keloids
JID Innovations, 2023 Keloids are benign, fibroproliferative dermal tumors that typically form owing to abnormal wound healing. The current standard of care is generally ineffective and does not prevent recurrence.
Yuan O. Zhu +13 more
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Molecular imaging of oxidative stress using an LED-based photoacoustic imaging system. [PDF]
, 2019 LED-based photoacoustic imaging has practical value in that it is affordable and rugged; however, this technology has largely been confined to anatomic imaging with limited applications into functional or molecular imaging.
Hariri, Ali +5 more
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Turmeric and curcumin: From traditional medicine to modern therapeutic applications
JSFA reports, EarlyView.Abstract Turmeric (Curcuma longa), a medicinal plant, has maintained its cultural and therapeutic significance over centuries in Ayurveda, Unani, and Traditional Chinese Medicine. However, novel formulations and delivery methods are being developed to address these challenges.
Azma Nadeem +7 more
wiley +1 more source
A Role for Neuregulin-1 in Promoting Keloid Fibroblast Migration via ErbB2-mediated Signaling
Acta Dermato-Venereologica, 2017 Keloid disease is a fibroproliferative tumour characterised by aggressive local invasion, evident from a clinically and histologically active migrating margin.
Natalie Jumper +3 more
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Genomic and proteomic profiling II: Comparative assessment of gene expression profiles in leiomyomas, keloids, and surgically-induced scars [PDF]
, 2007 Background Leiomyoma have often been compared to keloids because of their fibrotic characteristic and higher rate of occurrence among African Americans as compared to other ethnic groups.
Xiaoping Luo +3 more
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, 2006 The authors show a case of keloid that is reminiscent of the bow-tie, a male piece of apparel.Os autores relatam um caso de quelóide que reporta à gravata borboleta, acessório de trajes em geral masculinos.Universidade Federal de Juiz de Fora Hospital ...
Fraga, Juliana Cristina Silva +2 more
core +5 more sources
3D keloid spheroid model: Development and application for personalized drug response prediction
Communications BiologyResearch on keloid is limited by the lack of proper in vitro and animal model reflecting in vivo status. Based on heterogeneity of keloid and important role of endothelial cells in its pathogenesis, a novel 3D in vitro keloid spheroid prepared with ...
YoungHwan Choi +9 more
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