Results 61 to 70 of about 17,734 (244)

The effect of tranilast on fibroblast activation protein α (FAP-α) expression in normal and keloid fibroblasts in vitro [PDF]

, 2017
Introduction . Tranilast (N-(3’,4’-demethoxycinnamoyl)-anthranilic acid) is an anti-allergic drug. Its mechanism of action is based on the inhibition of antigen-induced release of chemical mediators from mast cells and basophils.
Paweł P. Antończak, Magdalena Jurzak, Agnieszka Garncarczyk, Magdalena Hartman-Petrycka, Katarzyna Adamczyk   +4 more
core   +1 more source

Efficacy and Safety of Small‐Spot 755 nm Picosecond Laser‐Induced Optical Breakdown for Novel Photomechanical Skin Ablation in Asian Patients

Lasers in Surgery and Medicine, EarlyView.
ABSTRACT Objectives Conventional ablative and photothermal lasers are commonly used to treat superficial pigmentary lesions but often induce thermal injury and post‐inflammatory hyperpigmentation (PIH), particularly in Asian skin. Picosecond 755‐nm alexandrite lasers with diffractive lens arrays (DLA) create laser‐induced optical breakdown (LIOB ...
Nai‐Wen Chai, Wan‐Chun Liao, Chang‐Cheng Chang, Po‐Hsuan Wei, Yung‑Hsueh Huang, Ying‐Chuan Hsu, Yen‑Jen Wang, Yu‐Tsung Chen   +7 more
wiley   +1 more source

Increased level of Histamine in keloid Tissue [PDF]

, 2020
Background: Keloid and hypertrophic scars (HTS) caused by an imbalance between the production and destruction of collagen during wound healing with an unknown underlying pathophysiological mechanism.
Niazi, Feizollah, Niazi, Sana, Soroush, Mohammad, Rostami, Khalil, Rajabi, Sadegh, Hedayatyanfard, Keshvad, Habibi, Behnam, Haddadi, Nazgol-Sadat, Khalili, Azadeh   +8 more
core   +1 more source

‘Aggressive Keloid’: A Severe Variant of Familial Keloid Scarring [PDF]

Journal of the Royal Society of Medicine, 2003
Keloid scars are nodular skin lesions that in severe forms resemble neoplasms and cause much physical and mental distress. Attempts at treatment can make them worse.
Bayat, Ardeshir, Arscott, Guyan, Ollier, William E R, Ferguson, Mark W J, McGrouther, D. Angus   +4 more
openaire   +3 more sources

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Tangential Excision of Keloid

, 1986
Twenty-nine cases of keloid were treated by tangential excision and split skin graft with good post-operative results in terms of contour, surface and colour match of the grafted area without any recurrence of the ...
Ashok G. Shah, Nimmi R. Lalwani
core   +1 more source

Incisional keloid

Pan African Medical Journal, 2018
A 24-year-old man underwent left ear tympanoplasty for chronic otitis media and 3 months later started developing asymptomatic, tumor-like, cutaneous lesion over the incision site. There was no pain or itching. The lesion gradually progressed in the subsequent years protruding behind the ear to cause apparent cosmetic deformity. A clinical diagnosis of
Pirabu Sakthivel, Chirom Amit Singh
openaire   +3 more sources

Genomics and epigenomics of tissue repair: Implications for personalized medicine

Precision Medical Sciences, EarlyView.
Genomic and epigenomic mechanisms govern tissue repair and regeneration through dynamic regulation of inflammation, cell fate, and extracellular matrix remodeling. The integration of multi‐omics, artificial intelligence, and precision regenerative therapies enables biomarker‐driven, personalized approaches to enhance healing and minimize fibrosis ...
Jharna Medhi, Chandrashekar Thalluri, Sarad Pawar Naik Bukke, Piyali Dey, Mallikarjun Vasam, Ananda Kumar Chettupalli, Swetha Kumari Koduru, Gali Avinash Kumar   +7 more
wiley   +1 more source

A clinical characterization of familial keloid disease in unique African tribes reveals distinct keloid phenotypes

, 2011
Background: This study is a clinical characterization of keloid scars in an African population comprising three rural tribes with familial keloids. Site distribution, morphologic features, and other characteristics of the scars were studied to assess ...
McGrouther, Duncan A., Yagi, Khalid I., Bayat, Ardeshir, Ardeshir Bayat, Black, Graeme, Graeme Black, Heise, Marco, Husam Bella, Marco Heise, Khalid I. Yagi, Bella, Husam, Duncan A. McGrouther   +11 more
core   +1 more source

USP37-stabilized SALL4 promotes the keloid formation by PI3K/AKT pathway

Scientific Reports
Spalt-like transcription factor 4 (SALL4) plays a vital role in the progression of many human diseases. However, the role and mechanism of SALL4 regulates in keloid formation remain unclear.
Shuo Fang, Zishuo Wang, Jianguo Xu, Miao Xu, Jiesong Zhou, Yuntong Zhang, Chunyu Xue   +6 more
doaj   +1 more source