Results 41 to 50 of about 18,369 (261)

Phase‐Programmed Microneedles Enable Sequential Hydrogen and Quercetin Release for Scar‐Reduced Regeneration of Burn Wounds

Advanced Science, EarlyView.
A phase‐programmed microneedle patch, comprising a poly (lactic‐co‐glycolic acid) (PLGA) shell and a sulfobutylether‐β‐cyclodextrin (SBECD) core, is designed for sequential hydrogen and quercetin release for scar‐reduced regeneration of burn wounds. ABSTRACT Burn wounds complicated by bacterial infection and fibrotic scarring remain a major clinical ...
Yongnian Zeng, Zhigang Chu, Huiyuan Yang, Wen Zhang, Peng Jiang, Jiapeng Lei, Siyu Zhang, Qiongfang Ruan, Shuhua Liu, Wei Li   +9 more
wiley   +1 more source

A Holistic Approach to Unravel Keloid Pathogenesis and Optimize Therapeutic Outcomes

Biomedicines
Although tremendous progress has been made over the past decades in elucidating the mechanisms of keloid formation and developing therapeutic interventions, keloid remains challenging to cure and prone to recurrence.
Zhendong Cao, Wei Liu
doaj   +1 more source

Single-cell RNA-seq reveals the communications between extracellular matrix-related components and Schwann cells contributing to the earlobe keloid formation

Frontiers in Medicine, 2022
Keloid is a major type of skin fibrotic disease, with one prominent feature of extensive accumulation of extracellular matrix (ECM) components, and another feature of pain/itching, which is closely related to the peripheral nervous system (PNS). However,
Taogen Gong, Taogen Gong, Yayu Wang, Shaowei Dong, Xiaoshi Ma, Danfeng Du, Chang Zou, Qijun Zheng, Zhong Wen   +8 more
doaj   +1 more source

MicroRNA in keloid pathogenesis [PDF]

, 2019
Keloid is a fibro-proliferative lesion that develops as a result of abnormal wound healing in susceptible individuals. Many factors such as skin tension, wound infection, racial difference and genetic predisposition have been implicated in the etiology ...
Ramin Ghazizadeh, Mohammad Ghazizadeh, Hajime Shimizu   +2 more
core  

Efficacy of Triamcinolone in Treatment of Keloid [PDF]

, 2022
Introduction Keloids are well known for recurrence. There is no standardized regimen for the treatment of keloids. Many different treatment modalities such as surgical excision, intralesional corticosteroids, radiotherapy, and pressure earrings have ...
Sathyaki D C, Nalina P A
core   +1 more source

Repeated intradermal lipopolysaccharide challenge responses in healthy volunteers: Implications for clinical pharmacology studies

British Journal of Clinical Pharmacology, EarlyView.
Aim Intradermal application of lipopolysaccharide (LPS), a Toll‐like receptor 4 agonist, induces a local inflammatory response and is used as a human challenge model to evaluate the pharmacodynamics of investigational medicinal products. While currently applied in a single, parallel‐group setting, alternative within‐subject designs involving repeated ...
Alexandra A. J. Sillé, Juliette A. van den Noort, Iva Lelios, Diana R. Pereira, Marzia A. Scelsi, Erica S. Klaassen, Philipp Schoenenberger, Naomi B. Klarenbeek, Pierre‐Eric Juif, Pascal Espie, Manon A. A. Jansen, Matthijs Moerland, Richard W. D. Welford   +12 more
wiley   +1 more source

IFNγ regulates ferroptosis in KFs by inhibiting the expression of SPOCD1 through DNMT3A

Cell Death Discovery
Keloid is benign skin tumor, and their curing is relatively difficult due to the unclear mechanism of formation. Inducing ferroptosis of keloid fibroblasts (KFs) may become a new method for treating keloid.
Xiuxia Wang, Yating Yang, Xianyu Zhou, Shun Yu, Xusong Luo, Lin Lu, Zhen Gao, Jun Yang   +7 more
doaj   +1 more source

Ferrostatin-1 inhibits fibroblast fibrosis in keloid by inhibiting ferroptosis [PDF]

PeerJ
Background Keloid is a chronic proliferative fibrotic disease caused by abnormal fibroblasts proliferation and excessive extracellular matrix (ECM) production.
Liu Yang, Xiuli Li, Yanli Wang
doaj   +2 more sources

3D Printing a Clinically Available Solution From Plaster‐Based Positives in Superficial Radiation Therapy

Journal of Medical Radiation Sciences, EarlyView.
This study compares two techniques for creating lead shielding masks to replace the current process for superficial/orthovoltage facial radiotherapy: Plaster Cast Positive Mould (PCPM), CT Scanned 3D Print (CT3DP), and Optical Scan 3D Print (OS3DP). CT3DP was found to be more accurate and preferred over OS3DP.
Rory Hartley, Linda Bell, Toby Lowe, Jeremy Booth, Sarah Bergamin, Dasantha Jayamanne, Ryan Brown   +6 more
wiley   +1 more source

3D keloid spheroid model: Development and application for personalized drug response prediction

Communications Biology
Research on keloid is limited by the lack of proper in vitro and animal model reflecting in vivo status. Based on heterogeneity of keloid and important role of endothelial cells in its pathogenesis, a novel 3D in vitro keloid spheroid prepared with ...
YoungHwan Choi, Hyung-Suk Jang, Joonho Shim, Eunhye Yeo, Min-Hee Kim, Hyungrye Noh, Sejin Oh, Ji-Hye Park, Dongyoun Lee, Jong Hee Lee   +9 more
doaj   +1 more source