Results 21 to 30 of about 13,368 (188)

Superior Antiproliferative and Enhanced Synergistic Effects of a ROCK Inhibitor in Multiple Models for Keloid Disease

JID Innovations
Keloid disease is a common fibroproliferative skin disorder characterized by excessive scar tissue formation and frequent recurrence. Limited therapies and study models hinder progress in addressing this unmet clinical need.
Zeinab Ghasemishahrestani, Traci A. Wilgus, Nonhlanhla P. Khumalo, Ardeshir Bayat   +3 more
doaj   +1 more source

Debulking keloid pada telinga kiri

Jurnal Kesehatan Andalas, 2018
Pendahuluan: Keloid adalah lesi proliferatif jinak dari jaringan konektif dermis yang biasanya dihasilkan dari respon jaringan terhadap trauma kulit pada orang-orang dengan predisposisi, dimana tidak sembuh secara spontan.
Ennesta Asri, Sri Lestari, Nadya Hasriningrum, Meligasari L Gaya   +3 more
doaj   +1 more source

Keloids [PDF]

JAMA Dermatology, 2021
Jared, Jagdeo, Eva, Kerby, Donald Alexander, Glass   +2 more
openaire   +2 more sources

Electrocardiographic and Skin Manifestations of Turner Syndrome: Association With Cardiovascular Disease

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Congenital heart disease (CHD) and dermatologic conditions such as lymphedema and acquired melanocytic nevi (AMN) are common in Turner Syndrome (TS). We hypothesized that abnormalities of cranial neural crest cell derivatives drive the skin and heart manifestations of TS. We conducted joint cardiac and skin examinations of volunteers at a 2023
Sarah Elsaim, Brett Vernier, Van Thi Thanh Truong, Riya T. Patel, Matthew Brown, Martin Chacon Portillo, Megan Rogge, David Rodriguez‐Buritica, Siddharth K. Prakash   +8 more
wiley   +1 more source

Comparison of rat hypertrophic scar models: Caudal tension model with superior pathological consistency

Animal Models and Experimental Medicine, EarlyView.
This study compared hypertrophic scar (HS) formation in SD rats at ear, back, and tail sites with or without mechanical tension. The ear model healed spontaneously by day 30. Dorsal full‐thickness excision (1 × 8 cm) produced moderate HS. In contrast, the tail tension model showed the greatest scar thickness, fibroblast density, collagen deposition ...
Lingyi Zhan, Hong Xiang, Yaohui Kong, Yunfeng Lei, Shuqi Xiao, Shiqi Chen, Jiaming Li, Ziwei Li, Rui Ni, Dan Peng, Yao Liu   +10 more
wiley   +1 more source

Defining a Unique Gene Expression Profile in Mature and Developing Keloids

JID Innovations, 2023
Keloids are benign, fibroproliferative dermal tumors that typically form owing to abnormal wound healing. The current standard of care is generally ineffective and does not prevent recurrence.
Yuan O. Zhu, Scott MacDonnell, Theodore Kaplan, Chien Liu, Yasmeen Ali, Stephanie M. Rangel, Matthew F. Wipperman, Madeleine Belback, Daphne S. Sun, Ziyou Ren, Xiaolong Alan Zhou, Gabor Halasz, Lori Morton, Roopal V. Kundu   +13 more
doaj   +1 more source

Repeated intradermal lipopolysaccharide challenge responses in healthy volunteers: Implications for clinical pharmacology studies

British Journal of Clinical Pharmacology, EarlyView.
Aim Intradermal application of lipopolysaccharide (LPS), a Toll‐like receptor 4 agonist, induces a local inflammatory response and is used as a human challenge model to evaluate the pharmacodynamics of investigational medicinal products. While currently applied in a single, parallel‐group setting, alternative within‐subject designs involving repeated ...
Alexandra A. J. Sillé, Juliette A. van den Noort, Iva Lelios, Diana R. Pereira, Marzia A. Scelsi, Erica S. Klaassen, Philipp Schoenenberger, Naomi B. Klarenbeek, Pierre‐Eric Juif, Pascal Espie, Manon A. A. Jansen, Matthijs Moerland, Richard W. D. Welford   +12 more
wiley   +1 more source

Dasatinib Attenuates Fibrosis in Keloids by Decreasing Senescent Cell Burden

Acta Dermato-Venereologica, 2023
Keloids are skin tumours caused by aberrant growth of dermal fibroblasts. Cellular senescence contributes to aging and various pathological conditions, including cancer, atherosclerosis, and fibrotic diseases.
Claudia C. Darmawan, Keunyoung Hur, Novi Kusumaningrum, Jin Ho Chung, Si-Hyung Lee, Je-Ho Mun   +5 more
doaj   +1 more source

3D Printing a Clinically Available Solution From Plaster‐Based Positives in Superficial Radiation Therapy

Journal of Medical Radiation Sciences, EarlyView.
This study compares two techniques for creating lead shielding masks to replace the current process for superficial/orthovoltage facial radiotherapy: Plaster Cast Positive Mould (PCPM), CT Scanned 3D Print (CT3DP), and Optical Scan 3D Print (OS3DP). CT3DP was found to be more accurate and preferred over OS3DP.
Rory Hartley, Linda Bell, Toby Lowe, Jeremy Booth, Sarah Bergamin, Dasantha Jayamanne, Ryan Brown   +6 more
wiley   +1 more source

Single-cell RNA-seq reveals the communications between extracellular matrix-related components and Schwann cells contributing to the earlobe keloid formation

Frontiers in Medicine, 2022
Keloid is a major type of skin fibrotic disease, with one prominent feature of extensive accumulation of extracellular matrix (ECM) components, and another feature of pain/itching, which is closely related to the peripheral nervous system (PNS). However,
Taogen Gong, Taogen Gong, Yayu Wang, Shaowei Dong, Xiaoshi Ma, Danfeng Du, Chang Zou, Qijun Zheng, Zhong Wen   +8 more
doaj   +1 more source