Results 31 to 40 of about 13,368 (188)

IFNγ regulates ferroptosis in KFs by inhibiting the expression of SPOCD1 through DNMT3A

Cell Death Discovery
Keloid is benign skin tumor, and their curing is relatively difficult due to the unclear mechanism of formation. Inducing ferroptosis of keloid fibroblasts (KFs) may become a new method for treating keloid.
Xiuxia Wang, Yating Yang, Xianyu Zhou, Shun Yu, Xusong Luo, Lin Lu, Zhen Gao, Jun Yang   +7 more
doaj   +1 more source

Ferrostatin-1 inhibits fibroblast fibrosis in keloid by inhibiting ferroptosis [PDF]

PeerJ
Background Keloid is a chronic proliferative fibrotic disease caused by abnormal fibroblasts proliferation and excessive extracellular matrix (ECM) production.
Liu Yang, Xiuli Li, Yanli Wang
doaj   +2 more sources

Quality of life in black African patients with keloid scars

Dermatology Reports, 2020
A keloid scar is a benign skin tumor and we aimed to assess the Quality of Life (QoL) of black Africans with keloid scars based on the Dermatology Life Quality Index (DLQI).
Komenan Kassi, Kanga Kouame, Alexandre Kouassi, Ange Allou, Isidore Kouassi, Sarah Kourouma, Elidje Ecra, Abdoulaye Sangare   +7 more
doaj   +1 more source

Ear Piercing Complications: Comparing Cartilage and Soft Tissue Piercings in a Large Survey Cohort

The Laryngoscope, EarlyView.
Cartilage ear piercings were associated with significantly higher complication rates than lobule piercings and remained an independent predictor of complications after multivariate analysis. Cartilage site also independently predicted piercing removal, with higher removal rates observed compared to lobule piercings.
John P. Ziegler, Nitin A. Pagedar, McKay Moline, Kathryn Marcus, Zachary G. Tanenbaum, Henry T. Hoffman, Scott R. Owen   +6 more
wiley   +1 more source

3D keloid spheroid model: Development and application for personalized drug response prediction

Communications Biology
Research on keloid is limited by the lack of proper in vitro and animal model reflecting in vivo status. Based on heterogeneity of keloid and important role of endothelial cells in its pathogenesis, a novel 3D in vitro keloid spheroid prepared with ...
YoungHwan Choi, Hyung-Suk Jang, Joonho Shim, Eunhye Yeo, Min-Hee Kim, Hyungrye Noh, Sejin Oh, Ji-Hye Park, Dongyoun Lee, Jong Hee Lee   +9 more
doaj   +1 more source

A Role for Neuregulin-1 in Promoting Keloid Fibroblast Migration via ErbB2-mediated Signaling

Acta Dermato-Venereologica, 2017
Keloid disease is a fibroproliferative tumour characterised by aggressive local invasion, evident from a clinically and histologically active migrating margin.
Natalie Jumper, Tom Hodgkinson, Ralf Paus, Ardeshir Bayat   +3 more
doaj   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

IL-13RA2 downregulation in fibroblasts promotes keloid fibrosis via JAK/STAT6 activation

JCI Insight, 2023
Keloids are considered the manifestation of a fibroproliferative disease characterized by chronic inflammation that is induced following skin injury. Deciphering the underlying mechanism of keloid formation is essential for improving treatment outcomes ...
Hua Chao, Lisheng Zheng, Pojui Hsu, Jinyun He, Ridong Wu, Shuqia Xu, Ruixi Zeng, Yuan Zhou, Huisi Ma, Haibo Liu, Qing Tang   +10 more
doaj   +1 more source

Research progress in the pathogenesis of keloids

Pifu-xingbing zhenliaoxue zazhi, 2023
During the process of skin wound healing, hyperproliferation of fibroblasts and excessive deposition of collagen in the extracellular matrix lead to the formation of keloid, a benign tumor with characteristics of aggressive growth.
Kunpeng JIA, Jing ZHOU
doaj   +1 more source

Dystrophia Smolandiensis is characterized by a novel NQO1 variant and a distinct phenotype from COL17A1‐associated epithelial recurrent erosion dystrophy

Acta Ophthalmologica, EarlyView.
Abstract Purpose To determine the molecular cause of the two epithelial recurrent erosion dystrophies, Dystrophia Smolandiensis and Dystrophia Helsinglandica, and to identify phenotypic differences between the two conditions. Methods DNA samples and clinical data from structured interview records were obtained from the Swedish families in which ...
Karl De Geer, Kristina Lagerstedt‐Robinson, Daniel Nilsson, Cilla Söderhäll, Björn Hammar, Erik Björck   +5 more
wiley   +1 more source