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A Holistic Approach to Unravel Keloid Pathogenesis and Optimize Therapeutic Outcomes [PDF]
BiomedicinesAlthough tremendous progress has been made over the past decades in elucidating the mechanisms of keloid formation and developing therapeutic interventions, keloid remains challenging to cure and prone to recurrence.
Zhendong Cao, Wei Liu
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Decoding the cGAS–STING–eosinophils predictive and natural therapeutic molecular signature in burn injury progression and keloid formation: insights from artificial intelligence-driven multiomics [PDF]
Frontiers in SurgeryBackgroundInflammation-related pathway activation contributes to the progression of burn injury and keloid formation.ObjectiveOur study aimed to investigate the role of the cGAS–STING pathway in regulating eosinophils during the progression of burn ...
Jingjing Li, Qinghua Yang
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The Keloid Disorder: Heterogeneity, Histopathology, Mechanisms and Models
Frontiers in Cell and Developmental Biology, 2020 Keloids constitute an abnormal fibroproliferative wound healing response in which raised scar tissue grows excessively and invasively beyond the original wound borders.
Frank Niessen +2 more
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Identification and histological validation of autophagy-related core genes ADRB2 and PLK2 in keloids, with integrated immune infiltration analysis [PDF]
Frontiers in ImmunologyIntroductionKeloids are pathological fibroproliferative scars characterized by excessive collagen deposition and a lack of effective targeted therapies.
Junjie Jin +7 more
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The epigenetics of keloids [PDF]
Experimental Dermatology, 2021 AbstractKeloid scarring is a fibroproliferative disorder of the skin with unknown pathophysiology, characterised by fibrotic tissue that extends beyond the boundaries of the original wound. Therapeutic options are few and commonly ineffective, with keloids very commonly recurring even after surgery and adjunct treatments.
Andrew W. Stevenson +5 more
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6: Biomimetic Microtissue Keloid Scar System Using Keloid-derived Fibroblasts and Macrophages
Plastic and Reconstructive Surgery, Global Open, 2021 Purpose: Keloid is a disease that affects millions of patients and has relatively few effective treatment options. Unfortunately, traditional 2D monolayer culture of keloid derived fibroblasts show little resemblance to the pathological process in vivo ...
Yu Tan, Ph.D +4 more
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Biomaterials Research, 2022 Silicone breast implants are commonly used for cosmetic and oncologic surgical indications owing to their inertness and being nontoxic. However, complications including capsular contracture and anaplastic large cell lymphoma have been associated with ...
Fatemeh Tavakoli Foroushani +5 more
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Juxta: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga, 2021 Introduction: Keloid and hypertrophic scar are pathological scars resulting from excessive accumulation of collagen in wound healing process. Data about profiles of keloid and hypertrophic scar are rarely found in Indonesia. Therefore, it is necessary to
Fania Ayu Wardani +2 more
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Journal of Pharmacy and Bioallied Sciences, 2021 Keloids are unorganized proliferation of fibrous tissue, usually arising from a site of injury, due to an aberrant healing process. Clinically, it presents as an ugly scar tissue on the skin and shows genetic predilection. They cause esthetic, physical, and psychological disturbances in the affected individuals.
Venkataramana Vannala +3 more
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Predictive Factors of Keloid Formation in Congenital Foot Syndactyly
Plastic and Reconstructive Surgery, Global Open, 2021 Background:. Keloid formation after syndactyly division is a stressful situation for patients. In our experience, digital enlargement may be involved in keloid formation following syndactyly divisions.
Sang Ho Oh, MD, Sang Hyun Woo, MD, PhD
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