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Collagen promotes PD-L1 overexpression in fibroblasts through binding to CD44 and activating YAP1 signaling during keloid formation [PDF]
Scientific ReportsKeloid is a skin collagen disease secondary to skin injury, characterized by excessive collagen deposition and a markedly high rate of recurrence. To date, there is still a lack of effective prevention and treatment methods for keloid. Thus, it is urgent
Lingfeng Chen +6 more
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Decoding the cGAS–STING–eosinophils predictive and natural therapeutic molecular signature in burn injury progression and keloid formation: insights from artificial intelligence-driven multiomics [PDF]
Frontiers in SurgeryBackgroundInflammation-related pathway activation contributes to the progression of burn injury and keloid formation.ObjectiveOur study aimed to investigate the role of the cGAS–STING pathway in regulating eosinophils during the progression of burn ...
Jingjing Li, Qinghua Yang
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6: Biomimetic Microtissue Keloid Scar System Using Keloid-derived Fibroblasts and Macrophages
Plastic and Reconstructive Surgery, Global Open, 2021 Purpose: Keloid is a disease that affects millions of patients and has relatively few effective treatment options. Unfortunately, traditional 2D monolayer culture of keloid derived fibroblasts show little resemblance to the pathological process in vivo ...
Yu Tan, Ph.D +4 more
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Biomaterials Research, 2022 Silicone breast implants are commonly used for cosmetic and oncologic surgical indications owing to their inertness and being nontoxic. However, complications including capsular contracture and anaplastic large cell lymphoma have been associated with ...
Fatemeh Tavakoli Foroushani +5 more
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Juxta: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga, 2021 Introduction: Keloid and hypertrophic scar are pathological scars resulting from excessive accumulation of collagen in wound healing process. Data about profiles of keloid and hypertrophic scar are rarely found in Indonesia. Therefore, it is necessary to
Fania Ayu Wardani +2 more
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Predictive Factors of Keloid Formation in Congenital Foot Syndactyly
Plastic and Reconstructive Surgery, Global Open, 2021 Background:. Keloid formation after syndactyly division is a stressful situation for patients. In our experience, digital enlargement may be involved in keloid formation following syndactyly divisions.
Sang Ho Oh, MD, Sang Hyun Woo, MD, PhD
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Experimental and Molecular Medicine, 2023 Keloid disorder is an abnormal fibroproliferative reaction that can occur on any area of skin, and it can impair the quality of life of affected individuals.
A Ram Lee +6 more
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F1000Research, 2017 Keloid disorder (KD) is an inherited wound healing ailment, frequently seen among Africans /African Americans and Asians. Genetics of this disorder continues to be obscure and poorly understood.
Michael Tirgan
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Identification and characterization of four immune-related signatures in keloid
Frontiers in Immunology, 2022 A keloid is a fibroproliferative disorder of unknown etiopathogenesis that requires ill-defined treatment. Existing evidence indicates that the immune system plays an important role in the occurrence and development of keloid.
Xiaoxiang Wang +10 more
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Expression of fibroblast-activation protein in keloid tissue and its clinical significance
Pifu-xingbing zhenliaoxue zazhi, 2020 Objective: To investigate the expression of fibroblast-activation protein(FAP) in keloid tissue and its role in the development of keloid. Methods: Immunochemical staining was used to evaluate the expression of FAP in 30 cases of keloid tissue (case ...
Yu-xiong ZOU, Ming-chun CHEN, Li-da XU
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