Results 61 to 70 of about 24,369 (267)

Finite Element Analysis of the Stress Changes Associated With the Growth of Acne Keloids

Plastic and Reconstructive Surgery, Global Open
Background:. Almost half of all spontaneously occurring keloids are acne keloids on the anterior chest. These keloids often grow in a crab-claw shape due to predominant tractional stresses on the scar; such stresses are risk factors for keloid growth ...
Nobuaki Ishii, MD, Satoshi Akaishi, MD, PhD, Masataka Akimoto, MD, PhD, Shizuko Ichinose, PhD, Satoshi Usami, PhD, Teruyuki Dohi, MD, PhD, Rei Ogawa, MD, PhD, FACS   +6 more
doaj   +1 more source

Single-cell RNA sequencing reveals distinct immunology profiles in human keloid

Frontiers in Immunology, 2022
Keloids, characterized by skin fibrosis and excessive accumulation of extracellular matrix, remain a therapeutic challenge. In this study, we systematically capture the cellular composition of keloids by the single-cell RNA sequencing technique.
Cheng Feng, Mengjie Shan, Mengjie Shan, Yijun Xia, Yijun Xia, Zhi Zheng, Kai He, Yingxin Wei, Kexin Song, Tian Meng, Hao Liu, Yan Hao, Yan Hao, Zhengyun Liang, Zhengyun Liang, Youbin Wang, Yongsheng Huang   +16 more
doaj   +1 more source

The Epidemiology of Keloids

, 2020
Keloids are pathological scars that are characterized histologically by an overwhelming aggregation of fibroblasts and collagen type I within the inflammatory reticular dermis.
Chenyu Huang, Zhaozhao Wu, Yanan Du, R. Ogawa   +3 more
semanticscholar   +1 more source

Repeated intradermal lipopolysaccharide challenge responses in healthy volunteers: Implications for clinical pharmacology studies

British Journal of Clinical Pharmacology, EarlyView.
Aim Intradermal application of lipopolysaccharide (LPS), a Toll‐like receptor 4 agonist, induces a local inflammatory response and is used as a human challenge model to evaluate the pharmacodynamics of investigational medicinal products. While currently applied in a single, parallel‐group setting, alternative within‐subject designs involving repeated ...
Alexandra A. J. Sillé, Juliette A. van den Noort, Iva Lelios, Diana R. Pereira, Marzia A. Scelsi, Erica S. Klaassen, Philipp Schoenenberger, Naomi B. Klarenbeek, Pierre‐Eric Juif, Pascal Espie, Manon A. A. Jansen, Matthijs Moerland, Richard W. D. Welford   +12 more
wiley   +1 more source

The outcome of postoperative radiation therapy following plastic surgical resection of recurrent ear keloid: a single institution experience

Journal of the Egyptian National Cancer Institute, 2022
Background Ear keloids are abnormal continuously growing healing process following cutaneous injury. Surgical excision is the standard treatment strategy; however, 50–80% of cases develop recurrence.
Reham Mohamed, Abosaleh Abosaleh Elawadi, Reham Al-Gendi, Safa Al-Mohsen, Shabeer Wani, Ahmed Wafa   +5 more
doaj   +1 more source

Elastic fiber assembly is disrupted by excessive accumulation of chondroitin sulfate in the human dermal fibrotic disease, keloid [PDF]

, 2009
Keloid is a fibrotic disease characterized by abnormal accumulation of extracellular matrix in the dermis. The keloid matrix contains excess collagen and glycosaminoglycans (GAGs), but lacks elastic fiber. However, the roles of these matrix components in
Ikeda, Mika, Ishiko, Toshihiro, Kubota, Hiroshi, Kurokawa, Masako, Nagata, Kazuhiro, Naitoh, Motoko, Nakamura, Tomiyuki, Suzuki, Shigehiko, Utani, Atsushi, Yamawaki, Satoko, Yoshikawa, Katsuhiro   +10 more
core   +1 more source

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source

Analysis of subsets and localization of macrophages in skin lesions and peripheral blood of patients with keloids

Heliyon
Keloids are a type of abnormal fibrous proliferation disease of the skin, characterized by local inflammation that lacks clear pathogenesis and satisfactory treatment.
Xinyi Lv, Zhenghao He, Ming Yang, Lu Wang, Siqi Fu   +4 more
doaj   +1 more source

Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies

Molecular Medicine, 2011
Excessive scars form as a result of aberrations of physiologic wound healing and may arise following any Insult to the deep dermis. By causing pain, pruritus and contractures, excessive scarring significantly affects the patient’s quality of life, both ...
G. Gauglitz, H. Korting, T. Pavicic, T. Ruzicka, M. Jeschke   +4 more
semanticscholar   +1 more source

Quantitative assessment of treatment efficacy in keloids using high-frequency ultrasound and shear wave elastography: a preliminary study

Scientific Reports, 2020
The purpose of this study was to investigate the performance of high-frequency ultrasound (HFUS) and shear wave elastography (SWE) in the quantitative evaluation of therapeutic responses of keloids.
Songya Huang, Xi Xiang, Ruiqian Guo, Shan Cheng, Liyun Wang, L. Qiu   +5 more
semanticscholar   +1 more source